Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats
Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good anti-diabetic, anti-hypertension, antioxidant, organ-protective, cardiovascular properties and other health benefits. Previous sub-chronic daily supplement of 500 mg kg-1 body weight (bw) for 3 months in rats showed no si...
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| Format: | Article |
| Language: | English |
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Academic Journals
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29896/1/Acute%20toxicity%20and%20safety%20assessment%20of%20oil%20palm.pdf |
| _version_ | 1796971632383754240 |
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| author | Anyanji, Victor Uchenna Mohamed, Suhaila Bejo, Mohd Hair |
| author_facet | Anyanji, Victor Uchenna Mohamed, Suhaila Bejo, Mohd Hair |
| author_sort | Anyanji, Victor Uchenna |
| collection | UPM |
| description | Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good anti-diabetic, anti-hypertension, antioxidant, organ-protective, cardiovascular properties and other health benefits. Previous sub-chronic daily supplement of 500 mg kg-1 body weight (bw) for 3 months in rats showed no significant adverse effects. The present investigation was carried out to evaluate the acute toxicity of the OPLE. The acute toxicity study was conducted by administering to the rats a single dose of either 2 or 5 g kg-1 bw. General behavior, body weights, other adverse effects and mortality were monitored for up to 14 days. Total white blood cells (WBC), lymphocyte, red blood cell (RBC) counts, hemoglobin concentrations and packed cell volume (PCV) were determined at 0, 1, 3, 7 and 14 days. Liver and kidney function markers were monitored and the effects on the essential organs were examined histologically. The no-observed adverse effects (NOAE) were seen in the 2 g dose, while at the 5 g dose, behavioral changes, grooming, tachycardia, heavy breathing and weakness lasted for 2 h. The 5 g dose also caused significant (P ≤ 0.05) reduction in RBC, hemoglobin and PCV although there was indifference in lymphocyte and WBC counts. Liver function markers and histology showed hepatocyte damage especially at day 7 in the 5 g dose, but there was partial recovery by the 14th day. The kidneys showed no significant changes. There was no death even at the 5 g dose, and the acute toxic injuries appeared reversible because the rats gradually recovered. In view of the NOAE dose of 2 g kg-1, the OPLE at the normal dose levels may be considered relatively safe for use. |
| first_indexed | 2024-03-06T08:15:53Z |
| format | Article |
| id | upm.eprints-29896 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:15:53Z |
| publishDate | 2013 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | upm.eprints-298962015-09-08T02:36:15Z http://psasir.upm.edu.my/id/eprint/29896/ Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats Anyanji, Victor Uchenna Mohamed, Suhaila Bejo, Mohd Hair Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good anti-diabetic, anti-hypertension, antioxidant, organ-protective, cardiovascular properties and other health benefits. Previous sub-chronic daily supplement of 500 mg kg-1 body weight (bw) for 3 months in rats showed no significant adverse effects. The present investigation was carried out to evaluate the acute toxicity of the OPLE. The acute toxicity study was conducted by administering to the rats a single dose of either 2 or 5 g kg-1 bw. General behavior, body weights, other adverse effects and mortality were monitored for up to 14 days. Total white blood cells (WBC), lymphocyte, red blood cell (RBC) counts, hemoglobin concentrations and packed cell volume (PCV) were determined at 0, 1, 3, 7 and 14 days. Liver and kidney function markers were monitored and the effects on the essential organs were examined histologically. The no-observed adverse effects (NOAE) were seen in the 2 g dose, while at the 5 g dose, behavioral changes, grooming, tachycardia, heavy breathing and weakness lasted for 2 h. The 5 g dose also caused significant (P ≤ 0.05) reduction in RBC, hemoglobin and PCV although there was indifference in lymphocyte and WBC counts. Liver function markers and histology showed hepatocyte damage especially at day 7 in the 5 g dose, but there was partial recovery by the 14th day. The kidneys showed no significant changes. There was no death even at the 5 g dose, and the acute toxic injuries appeared reversible because the rats gradually recovered. In view of the NOAE dose of 2 g kg-1, the OPLE at the normal dose levels may be considered relatively safe for use. Academic Journals 2013 Article NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29896/1/Acute%20toxicity%20and%20safety%20assessment%20of%20oil%20palm.pdf Anyanji, Victor Uchenna and Mohamed, Suhaila and Bejo, Mohd Hair (2013) Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats. Journal of Medicinal Plants Research, 7 (16). pp. 1022-1029. ISSN 1996-0875 http://www.academicjournals.org/journal/JMPR/edition/25_April,_2013 |
| spellingShingle | Anyanji, Victor Uchenna Mohamed, Suhaila Bejo, Mohd Hair Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats |
| title | Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats |
| title_full | Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats |
| title_fullStr | Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats |
| title_full_unstemmed | Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats |
| title_short | Acute toxicity and safety assessment of oil palm (Elaeis guineensis Jacq.) leaf extract in rats |
| title_sort | acute toxicity and safety assessment of oil palm elaeis guineensis jacq leaf extract in rats |
| url | http://psasir.upm.edu.my/id/eprint/29896/1/Acute%20toxicity%20and%20safety%20assessment%20of%20oil%20palm.pdf |
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