Lipase-catalyzed amino sugar derivative in tri-solvent mixture
In this work, a new type of amino sugar derivative tagged as amino sugar similar to N-acetyl-glucosamine, commonly used in medical field as medicine to treat osteoarthritis has been synthesized. This amino sugar derivative produced from glucose and propylamine with the aid of immobilized Candida ant...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Chemic Publishing Company
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/30025/1/Lipase.pdf |
| _version_ | 1825947625838346240 |
|---|---|
| author | Abdul Rahman, Mohd Basyaruddin Krishnan, Devandran Haron, Md. Jelas Tejo, Bimo Ario Abd. Malek, Emilia Salleh, Abu Bakar Basri, Mahiran |
| author_facet | Abdul Rahman, Mohd Basyaruddin Krishnan, Devandran Haron, Md. Jelas Tejo, Bimo Ario Abd. Malek, Emilia Salleh, Abu Bakar Basri, Mahiran |
| author_sort | Abdul Rahman, Mohd Basyaruddin |
| collection | UPM |
| description | In this work, a new type of amino sugar derivative tagged as amino sugar similar to N-acetyl-glucosamine, commonly used in medical field as medicine to treat osteoarthritis has been synthesized. This amino sugar derivative produced from glucose and propylamine with the aid of immobilized Candida antarctica (Novozyme 435) lipase, as catalyst. Mixtures of solvent influence the high solubility of sugar and thus increasing the yield. Optimization studies such as time, molar ratio, temperature and enzyme quantity conducted for optimization. Optimized condition yields 73.37 % amino sugar was obtained upon 2 h of reaction, 1:5 molar ratio of substrates, 40 ºC temperature and 17 % enzyme mass. |
| first_indexed | 2024-03-06T08:16:16Z |
| format | Article |
| id | upm.eprints-30025 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:16:16Z |
| publishDate | 2013 |
| publisher | Chemic Publishing Company |
| record_format | dspace |
| spelling | upm.eprints-300252015-09-15T01:52:40Z http://psasir.upm.edu.my/id/eprint/30025/ Lipase-catalyzed amino sugar derivative in tri-solvent mixture Abdul Rahman, Mohd Basyaruddin Krishnan, Devandran Haron, Md. Jelas Tejo, Bimo Ario Abd. Malek, Emilia Salleh, Abu Bakar Basri, Mahiran In this work, a new type of amino sugar derivative tagged as amino sugar similar to N-acetyl-glucosamine, commonly used in medical field as medicine to treat osteoarthritis has been synthesized. This amino sugar derivative produced from glucose and propylamine with the aid of immobilized Candida antarctica (Novozyme 435) lipase, as catalyst. Mixtures of solvent influence the high solubility of sugar and thus increasing the yield. Optimization studies such as time, molar ratio, temperature and enzyme quantity conducted for optimization. Optimized condition yields 73.37 % amino sugar was obtained upon 2 h of reaction, 1:5 molar ratio of substrates, 40 ºC temperature and 17 % enzyme mass. Chemic Publishing Company 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30025/1/Lipase.pdf Abdul Rahman, Mohd Basyaruddin and Krishnan, Devandran and Haron, Md. Jelas and Tejo, Bimo Ario and Abd. Malek, Emilia and Salleh, Abu Bakar and Basri, Mahiran (2013) Lipase-catalyzed amino sugar derivative in tri-solvent mixture. Asian Journal of Chemistry, 25 (6). pp. 3014-3018. ISSN 0970-7077 http://www.asianjournalofchemistry.co.in/User/SearchArticle.aspx?Volume=25&Issue=6&Article=&Criteria= 10.14233/ajchem.2013.13492 English |
| spellingShingle | Abdul Rahman, Mohd Basyaruddin Krishnan, Devandran Haron, Md. Jelas Tejo, Bimo Ario Abd. Malek, Emilia Salleh, Abu Bakar Basri, Mahiran Lipase-catalyzed amino sugar derivative in tri-solvent mixture |
| title | Lipase-catalyzed amino sugar derivative in tri-solvent mixture
|
| title_full | Lipase-catalyzed amino sugar derivative in tri-solvent mixture
|
| title_fullStr | Lipase-catalyzed amino sugar derivative in tri-solvent mixture
|
| title_full_unstemmed | Lipase-catalyzed amino sugar derivative in tri-solvent mixture
|
| title_short | Lipase-catalyzed amino sugar derivative in tri-solvent mixture
|
| title_sort | lipase catalyzed amino sugar derivative in tri solvent mixture |
| url | http://psasir.upm.edu.my/id/eprint/30025/1/Lipase.pdf |
| work_keys_str_mv | AT abdulrahmanmohdbasyaruddin lipasecatalyzedaminosugarderivativeintrisolventmixture AT krishnandevandran lipasecatalyzedaminosugarderivativeintrisolventmixture AT haronmdjelas lipasecatalyzedaminosugarderivativeintrisolventmixture AT tejobimoario lipasecatalyzedaminosugarderivativeintrisolventmixture AT abdmalekemilia lipasecatalyzedaminosugarderivativeintrisolventmixture AT sallehabubakar lipasecatalyzedaminosugarderivativeintrisolventmixture AT basrimahiran lipasecatalyzedaminosugarderivativeintrisolventmixture |