Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents
Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lympho...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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University of Karachi. Faculty of Pharmacy
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30037/1/Evaluation%20of%20biological%20activities%20of%20Alpinia%20mutica%20Roxb.pdf |
| _version_ | 1825947628169330688 |
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| author | Mustahil, Noorul Adawiyah Sukari, Mohd Aspollah Abdul, Ahmad Bustamam Ali, Nor Azah Ee, Gwendoline Cheng Lian |
| author_facet | Mustahil, Noorul Adawiyah Sukari, Mohd Aspollah Abdul, Ahmad Bustamam Ali, Nor Azah Ee, Gwendoline Cheng Lian |
| author_sort | Mustahil, Noorul Adawiyah |
| collection | UPM |
| description | Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude
extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 µg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 µg/mL.
Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl
(DPPH) radical scavenging activity tests. |
| first_indexed | 2024-03-06T08:16:18Z |
| format | Article |
| id | upm.eprints-30037 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:16:18Z |
| publishDate | 2013 |
| publisher | University of Karachi. Faculty of Pharmacy |
| record_format | dspace |
| spelling | upm.eprints-300372015-10-08T01:28:52Z http://psasir.upm.edu.my/id/eprint/30037/ Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents Mustahil, Noorul Adawiyah Sukari, Mohd Aspollah Abdul, Ahmad Bustamam Ali, Nor Azah Ee, Gwendoline Cheng Lian Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 µg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 µg/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests. University of Karachi. Faculty of Pharmacy 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30037/1/Evaluation%20of%20biological%20activities%20of%20Alpinia%20mutica%20Roxb.pdf Mustahil, Noorul Adawiyah and Sukari, Mohd Aspollah and Abdul, Ahmad Bustamam and Ali, Nor Azah and Ee, Gwendoline Cheng Lian (2013) Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents. Pakistan Journal of Pharmaceutical Sciences, 26 (2). pp. 391-395. ISSN 1011-601X English |
| spellingShingle | Mustahil, Noorul Adawiyah Sukari, Mohd Aspollah Abdul, Ahmad Bustamam Ali, Nor Azah Ee, Gwendoline Cheng Lian Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents |
| title | Evaluation of biological activities of Alpinia mutica Roxb.
and its chemical constituents |
| title_full | Evaluation of biological activities of Alpinia mutica Roxb.
and its chemical constituents |
| title_fullStr | Evaluation of biological activities of Alpinia mutica Roxb.
and its chemical constituents |
| title_full_unstemmed | Evaluation of biological activities of Alpinia mutica Roxb.
and its chemical constituents |
| title_short | Evaluation of biological activities of Alpinia mutica Roxb.
and its chemical constituents |
| title_sort | evaluation of biological activities of alpinia mutica roxb and its chemical constituents |
| url | http://psasir.upm.edu.my/id/eprint/30037/1/Evaluation%20of%20biological%20activities%20of%20Alpinia%20mutica%20Roxb.pdf |
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