Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils

Phenyl fatty hydroxamic acids (PFHAs) were synthesized by phenyl hydroxylaminolysis of canola or palm kernel oils using lipozyme TL IM as catalyst. Copper complexes of phenyl fatty hydroxamic acids (copper phenyl fatty hydroxamate (Cu-PFHs)) acids were prepared by stirring the phenyl fatty hydroxami...

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Main Authors: Haron, Md. Jelas, Jahangirian, Hossein, Ismail, Mohd. Halim Shah, Rafiee-Moghaddam, Roshanak, Rezayi, Majid, Shameli, Kamyar, Gharayebi, Yadollah, Abdollahi, Yadollah, Peyda, Mazyar, Mahdavi, Behnam
Format: Article
Language:English
English
Published: Chemic Publishing Company 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30084/1/Antifungal%20properties%20of%20phenyl%20fatty%20hydroxamic%20acids%20and%20their%20copper%20complexes%20synthesized%20based%20on%20canola%20and%20palm%20kernel%20oils.pdf
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author Haron, Md. Jelas
Jahangirian, Hossein
Ismail, Mohd. Halim Shah
Rafiee-Moghaddam, Roshanak
Rezayi, Majid
Shameli, Kamyar
Gharayebi, Yadollah
Abdollahi, Yadollah
Peyda, Mazyar
Mahdavi, Behnam
author_facet Haron, Md. Jelas
Jahangirian, Hossein
Ismail, Mohd. Halim Shah
Rafiee-Moghaddam, Roshanak
Rezayi, Majid
Shameli, Kamyar
Gharayebi, Yadollah
Abdollahi, Yadollah
Peyda, Mazyar
Mahdavi, Behnam
author_sort Haron, Md. Jelas
collection UPM
description Phenyl fatty hydroxamic acids (PFHAs) were synthesized by phenyl hydroxylaminolysis of canola or palm kernel oils using lipozyme TL IM as catalyst. Copper complexes of phenyl fatty hydroxamic acids (copper phenyl fatty hydroxamate (Cu-PFHs)) acids were prepared by stirring the phenyl fatty hydroxamic acids which were dissolved in hexane and copper(II) nitrate solution. The antifungal properties of phenyl fatty hydroxamic acids and its copper(II) complex Cu-PFHs based on canola and palm kernel oils were separately investigated against Candida parapsilosis, Candida albicans and Aspergillus fumigatus by the disc diffusion method using Mueller-Hinton agar. The results showed that antifungal activity of Cu-PFHs is higher than phenyl fatty hydroxamic acids do and also the activity of phenyl fatty hydroxamic acids and Cu-PFHs increase while their concentrations increase. The antifungal activity of phenyl fatty hydroxamic acids and Cu-PFHs are significantly higher than nystatin while use against the A. fumigatus, C. parapsilosis and C. albicans and also are significantly higher than ketoconazole while use against the A. fumigatus.
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spelling upm.eprints-300842015-09-11T00:45:43Z http://psasir.upm.edu.my/id/eprint/30084/ Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils Haron, Md. Jelas Jahangirian, Hossein Ismail, Mohd. Halim Shah Rafiee-Moghaddam, Roshanak Rezayi, Majid Shameli, Kamyar Gharayebi, Yadollah Abdollahi, Yadollah Peyda, Mazyar Mahdavi, Behnam Phenyl fatty hydroxamic acids (PFHAs) were synthesized by phenyl hydroxylaminolysis of canola or palm kernel oils using lipozyme TL IM as catalyst. Copper complexes of phenyl fatty hydroxamic acids (copper phenyl fatty hydroxamate (Cu-PFHs)) acids were prepared by stirring the phenyl fatty hydroxamic acids which were dissolved in hexane and copper(II) nitrate solution. The antifungal properties of phenyl fatty hydroxamic acids and its copper(II) complex Cu-PFHs based on canola and palm kernel oils were separately investigated against Candida parapsilosis, Candida albicans and Aspergillus fumigatus by the disc diffusion method using Mueller-Hinton agar. The results showed that antifungal activity of Cu-PFHs is higher than phenyl fatty hydroxamic acids do and also the activity of phenyl fatty hydroxamic acids and Cu-PFHs increase while their concentrations increase. The antifungal activity of phenyl fatty hydroxamic acids and Cu-PFHs are significantly higher than nystatin while use against the A. fumigatus, C. parapsilosis and C. albicans and also are significantly higher than ketoconazole while use against the A. fumigatus. Chemic Publishing Company 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30084/1/Antifungal%20properties%20of%20phenyl%20fatty%20hydroxamic%20acids%20and%20their%20copper%20complexes%20synthesized%20based%20on%20canola%20and%20palm%20kernel%20oils.pdf Haron, Md. Jelas and Jahangirian, Hossein and Ismail, Mohd. Halim Shah and Rafiee-Moghaddam, Roshanak and Rezayi, Majid and Shameli, Kamyar and Gharayebi, Yadollah and Abdollahi, Yadollah and Peyda, Mazyar and Mahdavi, Behnam (2013) Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils. Asian Journal of Chemistry, 25 (8). pp. 4183-4188. ISSN 0970-7077 English
spellingShingle Haron, Md. Jelas
Jahangirian, Hossein
Ismail, Mohd. Halim Shah
Rafiee-Moghaddam, Roshanak
Rezayi, Majid
Shameli, Kamyar
Gharayebi, Yadollah
Abdollahi, Yadollah
Peyda, Mazyar
Mahdavi, Behnam
Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils
title Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils
title_full Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils
title_fullStr Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils
title_full_unstemmed Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils
title_short Antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils
title_sort antifungal properties of phenyl fatty hydroxamic acids and their copper complexes synthesized based on canola and palm kernel oils
url http://psasir.upm.edu.my/id/eprint/30084/1/Antifungal%20properties%20of%20phenyl%20fatty%20hydroxamic%20acids%20and%20their%20copper%20complexes%20synthesized%20based%20on%20canola%20and%20palm%20kernel%20oils.pdf
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