α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study
Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer. This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer. AM is a prenylated xanthone derived through biologically...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30158/1/%CE%B1-Mangostin%20from%20cratoxylum%20arborescens%20%28Vahl%29%20blume%20demonstrates%20anti-ulcerogenic%20property%20.pdf |
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| author | Sidahmed, Heyam M. A. Abdelwahab, Siddig Ibrahim Mohan, Syam Abdulla, Mahmood Ameen Elhassan Taha, Manal Mohamed Mohd Hashim, Najihah A. Hadi, A. Hamid Vadivelu, Jamunarani Loke, Mun Fai Rahmani, Mawardi Yahayu, Maizatulakmal |
| author_facet | Sidahmed, Heyam M. A. Abdelwahab, Siddig Ibrahim Mohan, Syam Abdulla, Mahmood Ameen Elhassan Taha, Manal Mohamed Mohd Hashim, Najihah A. Hadi, A. Hamid Vadivelu, Jamunarani Loke, Mun Fai Rahmani, Mawardi Yahayu, Maizatulakmal |
| author_sort | Sidahmed, Heyam M. A. |
| collection | UPM |
| description | Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer. This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer. AM is a prenylated xanthone derived through biologically guided fractionation of C. arborescens. Rats were orally pretreated with AM and subsequently exposed to acute gastric lesions induced by ethanol. Following treatment, ulcer index, gastric juice acidity, mucus content, histological and immunohistochemical analyses, glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and nonprotein sulfhydryl groups (NP-SH) were evaluated. The anti-Helicobacter pylori, cyclooxygenase-2 (COX-2) inhibitory effect, and antioxidant activity of AM were also investigated in vitro. AM (10 and 30 mg/kg) inhibited significantly (P < 0.05) ethanol-induced gastric lesions by 66.04% and 74.39 %, respectively. The compound induces the expression of Hsp70, restores GSH levels, decreases lipid peroxidation, and inhibits COX-2 activity. The minimum inhibitory concentration (MIC) of AM showed an effective in vitro anti-H. pylori activity. The efficacy of the AM was accomplished safely without presenting any toxicological parameters. The results of the present study indicate that the antioxidant properties and the potent anti-H. pylori, in addition to activation of Hsp70 protein, may contribute to the gastroprotective activity of α-mangostin. |
| first_indexed | 2024-03-06T08:16:40Z |
| format | Article |
| id | upm.eprints-30158 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:16:40Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | upm.eprints-301582016-02-05T01:35:43Z http://psasir.upm.edu.my/id/eprint/30158/ α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study Sidahmed, Heyam M. A. Abdelwahab, Siddig Ibrahim Mohan, Syam Abdulla, Mahmood Ameen Elhassan Taha, Manal Mohamed Mohd Hashim, Najihah A. Hadi, A. Hamid Vadivelu, Jamunarani Loke, Mun Fai Rahmani, Mawardi Yahayu, Maizatulakmal Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer. This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer. AM is a prenylated xanthone derived through biologically guided fractionation of C. arborescens. Rats were orally pretreated with AM and subsequently exposed to acute gastric lesions induced by ethanol. Following treatment, ulcer index, gastric juice acidity, mucus content, histological and immunohistochemical analyses, glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and nonprotein sulfhydryl groups (NP-SH) were evaluated. The anti-Helicobacter pylori, cyclooxygenase-2 (COX-2) inhibitory effect, and antioxidant activity of AM were also investigated in vitro. AM (10 and 30 mg/kg) inhibited significantly (P < 0.05) ethanol-induced gastric lesions by 66.04% and 74.39 %, respectively. The compound induces the expression of Hsp70, restores GSH levels, decreases lipid peroxidation, and inhibits COX-2 activity. The minimum inhibitory concentration (MIC) of AM showed an effective in vitro anti-H. pylori activity. The efficacy of the AM was accomplished safely without presenting any toxicological parameters. The results of the present study indicate that the antioxidant properties and the potent anti-H. pylori, in addition to activation of Hsp70 protein, may contribute to the gastroprotective activity of α-mangostin. Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30158/1/%CE%B1-Mangostin%20from%20cratoxylum%20arborescens%20%28Vahl%29%20blume%20demonstrates%20anti-ulcerogenic%20property%20.pdf Sidahmed, Heyam M. A. and Abdelwahab, Siddig Ibrahim and Mohan, Syam and Abdulla, Mahmood Ameen and Elhassan Taha, Manal Mohamed and Mohd Hashim, Najihah and A. Hadi, A. Hamid and Vadivelu, Jamunarani and Loke, Mun Fai and Rahmani, Mawardi and Yahayu, Maizatulakmal (2013) α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study. Evidence-Based Complementary and Alternative Medicine, 2013. art. no. 450840. pp. 1-10. ISSN 1741-427X; ESSN: 1741-4288 http://www.hindawi.com/journals/ecam/2013/450840/ 10.1155/2013/450840 |
| spellingShingle | Sidahmed, Heyam M. A. Abdelwahab, Siddig Ibrahim Mohan, Syam Abdulla, Mahmood Ameen Elhassan Taha, Manal Mohamed Mohd Hashim, Najihah A. Hadi, A. Hamid Vadivelu, Jamunarani Loke, Mun Fai Rahmani, Mawardi Yahayu, Maizatulakmal α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study |
| title | α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study |
| title_full | α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study |
| title_fullStr | α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study |
| title_full_unstemmed | α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study |
| title_short | α-Mangostin from cratoxylum arborescens (Vahl) blume demonstrates anti-ulcerogenic property : a mechanistic study |
| title_sort | α mangostin from cratoxylum arborescens vahl blume demonstrates anti ulcerogenic property a mechanistic study |
| url | http://psasir.upm.edu.my/id/eprint/30158/1/%CE%B1-Mangostin%20from%20cratoxylum%20arborescens%20%28Vahl%29%20blume%20demonstrates%20anti-ulcerogenic%20property%20.pdf |
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