Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion
Conductive polymer poly(aniline-co-m-aminobenzoic acid) (P(ANI-co-m-ABA)) and polyaniline (PANI) were blended with a biodegradable, biocompatible polymer, poly(l-lactic acid) and were electrospun into nanofibres to investigate their potential application as a scaffold for human adipose-derived stem...
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| Format: | Article |
| Language: | English English |
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Elsevier
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30165/1/Functional%20polyaniline%20nanofibre%20mats%20for%20human%20adipose.pdf |
| _version_ | 1796971686266929152 |
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| author | Abdul Rahman, Norizah Feisst, Vaughan Dickinson, Michelle E. Malmstrom, Jenny Dunbar, P. Rod Travas Sejdic, Jadranka |
| author_facet | Abdul Rahman, Norizah Feisst, Vaughan Dickinson, Michelle E. Malmstrom, Jenny Dunbar, P. Rod Travas Sejdic, Jadranka |
| author_sort | Abdul Rahman, Norizah |
| collection | UPM |
| description | Conductive polymer poly(aniline-co-m-aminobenzoic acid) (P(ANI-co-m-ABA)) and polyaniline (PANI) were blended with a biodegradable, biocompatible polymer, poly(l-lactic acid) and were electrospun into nanofibres to investigate their potential application as a scaffold for human adipose-derived stem cells (hASCs). These polymers, in both conductive and non-conductive form, were electrospun with average fibre diameters of less than 400 nm. Novel nanoindentation results obtained on the individual nanofibres revealed that the elastic moduli of the nanofibres are much higher at the surface (4–10 GPa, hmax <75 nm) than in the inner fibre core (2–4 GPa, hmax >75 nm). The composite nanofibres showed great promise as a scaffold for hASCs as they supported the cell adhesion and proliferation. After 1 week of cell culture hASCs were well spread on the substrates with abundant focal adhesions. The electrospun mats provide the cells with comparably stiff, sub-micron sized fibres as anchoring points on a substrate of high porosity. The conductive nature of these composite nanofibres offers exciting opportunities for electrical stimulation of the cells. |
| first_indexed | 2024-03-06T08:16:41Z |
| format | Article |
| id | upm.eprints-30165 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:16:41Z |
| publishDate | 2013 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-301652015-09-10T08:01:32Z http://psasir.upm.edu.my/id/eprint/30165/ Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion Abdul Rahman, Norizah Feisst, Vaughan Dickinson, Michelle E. Malmstrom, Jenny Dunbar, P. Rod Travas Sejdic, Jadranka Conductive polymer poly(aniline-co-m-aminobenzoic acid) (P(ANI-co-m-ABA)) and polyaniline (PANI) were blended with a biodegradable, biocompatible polymer, poly(l-lactic acid) and were electrospun into nanofibres to investigate their potential application as a scaffold for human adipose-derived stem cells (hASCs). These polymers, in both conductive and non-conductive form, were electrospun with average fibre diameters of less than 400 nm. Novel nanoindentation results obtained on the individual nanofibres revealed that the elastic moduli of the nanofibres are much higher at the surface (4–10 GPa, hmax <75 nm) than in the inner fibre core (2–4 GPa, hmax >75 nm). The composite nanofibres showed great promise as a scaffold for hASCs as they supported the cell adhesion and proliferation. After 1 week of cell culture hASCs were well spread on the substrates with abundant focal adhesions. The electrospun mats provide the cells with comparably stiff, sub-micron sized fibres as anchoring points on a substrate of high porosity. The conductive nature of these composite nanofibres offers exciting opportunities for electrical stimulation of the cells. Elsevier 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30165/1/Functional%20polyaniline%20nanofibre%20mats%20for%20human%20adipose.pdf Abdul Rahman, Norizah and Feisst, Vaughan and Dickinson, Michelle E. and Malmstrom, Jenny and Dunbar, P. Rod and Travas Sejdic, Jadranka (2013) Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion. Materials Chemistry and Physics, 138 (1). pp. 333-341. ISSN 0254-0584 10.1016/j.matchemphys.2012.11.065 English |
| spellingShingle | Abdul Rahman, Norizah Feisst, Vaughan Dickinson, Michelle E. Malmstrom, Jenny Dunbar, P. Rod Travas Sejdic, Jadranka Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion |
| title | Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion |
| title_full | Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion |
| title_fullStr | Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion |
| title_full_unstemmed | Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion |
| title_short | Functional polyaniline nanofibre mats for human adipose-derived stem cell proliferation and adhesion |
| title_sort | functional polyaniline nanofibre mats for human adipose derived stem cell proliferation and adhesion |
| url | http://psasir.upm.edu.my/id/eprint/30165/1/Functional%20polyaniline%20nanofibre%20mats%20for%20human%20adipose.pdf |
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