Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems.
The synergistic antioxidant effects of ethanolic extracts of Centella asiatica (CE), and α-tocopherol have been studied. The types of interactions exhibited by CE and α-tocopherol combined at different ratios were measured using three assays: 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30439/1/Antioxidant%20synergism%20between%20ethanolic%20Centella%20asiatica%20extracts%20and%20%CE%B1.pdf |
| _version_ | 1825947707399733248 |
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| author | Thoo, Yin Yin Abas, Faridah Lai, Oi Ming Chun, Wai Ho Jie, Yin Hedegaard, Rikke V. Skibsted, Leif H. Tan, Chin Ping |
| author_facet | Thoo, Yin Yin Abas, Faridah Lai, Oi Ming Chun, Wai Ho Jie, Yin Hedegaard, Rikke V. Skibsted, Leif H. Tan, Chin Ping |
| author_sort | Thoo, Yin Yin |
| collection | UPM |
| description | The synergistic antioxidant effects of ethanolic extracts of Centella asiatica (CE), and α-tocopherol have been studied. The types of interactions exhibited by CE and α-tocopherol combined at different ratios were measured using three assays: 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical-scavenging capacity, the β-carotene bleaching system and liposome peroxidation assays. Fixed-fraction isobolographic analysis was used to detect any inducement of the antioxidant activity compared with the individual activities of CE and α-tocopherol. Of all synergistic combinations of CE and α-tocopherol, only fraction 2/3 showed the synergistic combination that fits well in three different assays and can be explained by the regeneration of α-tocopherol by CE despite the interaction effect of β-carotene present in the analytical assay. This phenomenon involved complex interactions between CE and α-tocopherol to exhibit different degrees of interactions that eventually increased antioxidant activity. |
| first_indexed | 2024-03-06T08:17:34Z |
| format | Article |
| id | upm.eprints-30439 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T08:17:34Z |
| publishDate | 2013 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-304392015-12-29T03:18:27Z http://psasir.upm.edu.my/id/eprint/30439/ Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. Thoo, Yin Yin Abas, Faridah Lai, Oi Ming Chun, Wai Ho Jie, Yin Hedegaard, Rikke V. Skibsted, Leif H. Tan, Chin Ping The synergistic antioxidant effects of ethanolic extracts of Centella asiatica (CE), and α-tocopherol have been studied. The types of interactions exhibited by CE and α-tocopherol combined at different ratios were measured using three assays: 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical-scavenging capacity, the β-carotene bleaching system and liposome peroxidation assays. Fixed-fraction isobolographic analysis was used to detect any inducement of the antioxidant activity compared with the individual activities of CE and α-tocopherol. Of all synergistic combinations of CE and α-tocopherol, only fraction 2/3 showed the synergistic combination that fits well in three different assays and can be explained by the regeneration of α-tocopherol by CE despite the interaction effect of β-carotene present in the analytical assay. This phenomenon involved complex interactions between CE and α-tocopherol to exhibit different degrees of interactions that eventually increased antioxidant activity. Elsevier 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30439/1/Antioxidant%20synergism%20between%20ethanolic%20Centella%20asiatica%20extracts%20and%20%CE%B1.pdf Thoo, Yin Yin and Abas, Faridah and Lai, Oi Ming and Chun, Wai Ho and Jie, Yin and Hedegaard, Rikke V. and Skibsted, Leif H. and Tan, Chin Ping (2013) Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. Food Chemistry, 138 (2-3). pp. 1215-1219. ISSN 0308-8146 10.1016/j.foodchem.2012.11.013 English |
| spellingShingle | Thoo, Yin Yin Abas, Faridah Lai, Oi Ming Chun, Wai Ho Jie, Yin Hedegaard, Rikke V. Skibsted, Leif H. Tan, Chin Ping Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. |
| title | Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. |
| title_full | Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. |
| title_fullStr | Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. |
| title_full_unstemmed | Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. |
| title_short | Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems. |
| title_sort | antioxidant synergism between ethanolic centella asiatica extracts and α tocopherol in model systems |
| url | http://psasir.upm.edu.my/id/eprint/30439/1/Antioxidant%20synergism%20between%20ethanolic%20Centella%20asiatica%20extracts%20and%20%CE%B1.pdf |
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