Effects of S-adenosyl-L-homocysteine and trichostatin A on developmental competence, epigenetic modification, and gene expression in cloned cattle embryos
With regards to low efficiency of the somatic cell nuclear transfer (SCNT)procedure the hypothesis that epigenetic marks of somatic donor cells are responsible for this inefficiency is proposed. Epigenetic marks such as DNA methylation and histone acetylation are two major participants in nuclear...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/31916/7/FP%202012%209%20pdf.pdf |