Circular antiviral RNA
The present invention relates to triple helix forming oligonucleotides (TFO) for use in the treatment of diseases mediated by single stranded RNA viruses, for example corona viruses. The invention provides a selection of circular TFO sequences that target different regions of the genome of the virul...
| Main Authors: | , , , |
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| Format: | Patent |
| Published: |
2012
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| _version_ | 1825948234020814848 |
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| author | Omar, Abdul Rahman Tejo, Bimo Ario Tan, Sheau Wei Choong, Oi Kuan |
| author_facet | Omar, Abdul Rahman Tejo, Bimo Ario Tan, Sheau Wei Choong, Oi Kuan |
| author_sort | Omar, Abdul Rahman |
| collection | UPM |
| description | The present invention relates to triple helix forming oligonucleotides (TFO) for use in the treatment of diseases mediated by single stranded RNA viruses, for example corona viruses. The invention provides a selection of circular TFO sequences that target different regions of the genome of the virulent Feline coronavirus and that efficiently block the virus’ replication. Thereby the TFO of the present invention provide new means for therapy against viral diseases. The invention relates to the novel TFOs, pharmaceutical compositions comprising the same, the new TFO design and their uses in the treatment of viral diseases. |
| first_indexed | 2024-03-06T08:25:34Z |
| format | Patent |
| id | upm.eprints-33269 |
| institution | Universiti Putra Malaysia |
| last_indexed | 2024-03-06T08:25:34Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | upm.eprints-332692016-09-02T06:18:11Z http://psasir.upm.edu.my/id/eprint/33269/ Circular antiviral RNA Omar, Abdul Rahman Tejo, Bimo Ario Tan, Sheau Wei Choong, Oi Kuan The present invention relates to triple helix forming oligonucleotides (TFO) for use in the treatment of diseases mediated by single stranded RNA viruses, for example corona viruses. The invention provides a selection of circular TFO sequences that target different regions of the genome of the virulent Feline coronavirus and that efficiently block the virus’ replication. Thereby the TFO of the present invention provide new means for therapy against viral diseases. The invention relates to the novel TFOs, pharmaceutical compositions comprising the same, the new TFO design and their uses in the treatment of viral diseases. 2012-04-25 Patent NonPeerReviewed Abdul Rahman Omar (2012) Circular antiviral RNA. PI2012001820. |
| spellingShingle | Omar, Abdul Rahman Tejo, Bimo Ario Tan, Sheau Wei Choong, Oi Kuan Circular antiviral RNA |
| title | Circular antiviral RNA |
| title_full | Circular antiviral RNA |
| title_fullStr | Circular antiviral RNA |
| title_full_unstemmed | Circular antiviral RNA |
| title_short | Circular antiviral RNA |
| title_sort | circular antiviral rna |
| work_keys_str_mv | AT omarabdulrahman circularantiviralrna AT tejobimoario circularantiviralrna AT tansheauwei circularantiviralrna AT choongoikuan circularantiviralrna |