Effect of short term starvation on disposition kinetics of chloramphenicol in goats
The effect of short term starvation on the disposition kinetics of chloramphenicol was determined in goats. The same dosage level (10 mg kg-1) administered intravenously produced higher serum concentrations in the animals when they were starved than when they were not starved. This could be attribut...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Harcourt Publishers Limited
1986
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34101/1/19.%2034101%20effect%20of%20short%20term.pdf http://psasir.upm.edu.my/id/eprint/34101/7/1-s2.0-S0034528818305551-main.pdf |
| _version_ | 1825948385422606336 |
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| author | Abdullah, A. Salam Baggot, J. D. |
| author_facet | Abdullah, A. Salam Baggot, J. D. |
| author_sort | Abdullah, A. Salam |
| collection | UPM |
| description | The effect of short term starvation on the disposition kinetics of chloramphenicol was determined in goats. The same dosage level (10 mg kg-1) administered intravenously produced higher serum concentrations in the animals when they were starved than when they were not starved. This could be attributed to the significantly smaller (P less than 0.05) volume of the central compartment. Starvation significantly decreased the rate of elimination of chloramphenicol while the apparent volume of distribution of the drug was not altered. A significant decrease in the body clearance, 1.36 +/- 0.95 ml (min kg)-1 in the starved condition compared with 3.78 +/- 2.19 mg (min kg)-1 in the controls, caused a corresponding increase in the half life of chloramphenicol. The decreased rate of elimination was attributed to decreased hepatic microsomal metabolism since starvation did not change the fraction of the dose excreted unchanged in the urine. The clinical significance of the altered disposition of chloramphenicol is that administration at the usual dosing rate would lead to accumulation of the drug and eventual toxicity |
| first_indexed | 2024-03-06T08:28:01Z |
| format | Article |
| id | upm.eprints-34101 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-09-25T03:33:48Z |
| publishDate | 1986 |
| publisher | Harcourt Publishers Limited |
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| spelling | upm.eprints-341012024-08-08T03:13:06Z http://psasir.upm.edu.my/id/eprint/34101/ Effect of short term starvation on disposition kinetics of chloramphenicol in goats Abdullah, A. Salam Baggot, J. D. The effect of short term starvation on the disposition kinetics of chloramphenicol was determined in goats. The same dosage level (10 mg kg-1) administered intravenously produced higher serum concentrations in the animals when they were starved than when they were not starved. This could be attributed to the significantly smaller (P less than 0.05) volume of the central compartment. Starvation significantly decreased the rate of elimination of chloramphenicol while the apparent volume of distribution of the drug was not altered. A significant decrease in the body clearance, 1.36 +/- 0.95 ml (min kg)-1 in the starved condition compared with 3.78 +/- 2.19 mg (min kg)-1 in the controls, caused a corresponding increase in the half life of chloramphenicol. The decreased rate of elimination was attributed to decreased hepatic microsomal metabolism since starvation did not change the fraction of the dose excreted unchanged in the urine. The clinical significance of the altered disposition of chloramphenicol is that administration at the usual dosing rate would lead to accumulation of the drug and eventual toxicity Harcourt Publishers Limited 1986-05 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/34101/1/19.%2034101%20effect%20of%20short%20term.pdf text en http://psasir.upm.edu.my/id/eprint/34101/7/1-s2.0-S0034528818305551-main.pdf Abdullah, A. Salam and Baggot, J. D. (1986) Effect of short term starvation on disposition kinetics of chloramphenicol in goats. Research in Veterinary Science, 40 (3). pp. 382-385. ISSN 0034-5288 |
| spellingShingle | Abdullah, A. Salam Baggot, J. D. Effect of short term starvation on disposition kinetics of chloramphenicol in goats |
| title | Effect of short term starvation on disposition kinetics of chloramphenicol in goats |
| title_full | Effect of short term starvation on disposition kinetics of chloramphenicol in goats |
| title_fullStr | Effect of short term starvation on disposition kinetics of chloramphenicol in goats |
| title_full_unstemmed | Effect of short term starvation on disposition kinetics of chloramphenicol in goats |
| title_short | Effect of short term starvation on disposition kinetics of chloramphenicol in goats |
| title_sort | effect of short term starvation on disposition kinetics of chloramphenicol in goats |
| url | http://psasir.upm.edu.my/id/eprint/34101/1/19.%2034101%20effect%20of%20short%20term.pdf http://psasir.upm.edu.my/id/eprint/34101/7/1-s2.0-S0034528818305551-main.pdf |
| work_keys_str_mv | AT abdullahasalam effectofshorttermstarvationondispositionkineticsofchloramphenicolingoats AT baggotjd effectofshorttermstarvationondispositionkineticsofchloramphenicolingoats |