In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system
The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanopart...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34152/1/In%20Vitro%20Sustained%20Release%20Study%20of%20Gallic%20Acid%20Coated%20with.pdf |
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| author | Dorniani, Dena Kura, Aminu Umar Hussein-Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah |
| author_facet | Dorniani, Dena Kura, Aminu Umar Hussein-Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah |
| author_sort | Dorniani, Dena |
| collection | UPM |
| description | The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively. Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics. Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG. |
| first_indexed | 2024-03-06T08:28:08Z |
| format | Article |
| id | upm.eprints-34152 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:28:08Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | upm.eprints-341522015-12-07T06:53:27Z http://psasir.upm.edu.my/id/eprint/34152/ In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system Dorniani, Dena Kura, Aminu Umar Hussein-Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah The efficacy of two nanocarriers polyethylene glycol and polyvinyl alcohol magnetic nanoparticles coated with gallic acid (GA) was accomplished via X-ray diffraction, infrared spectroscopy, magnetic measurements, thermal analysis, and TEM. X-ray diffraction and TEM results showed that Fe3O4 nanoparticles were pure iron oxide having spherical shape with the average diameter of 9 nm, compared with 31 nm and 35 nm after coating with polyethylene glycol-GA (FPEGG) and polyvinyl alcohol-GA (FPVAG), respectively. Thermogravimetric analyses proved that after coating the thermal stability was markedly enhanced. Magnetic measurements and Fourier transform infrared (FTIR) revealed that superparamagnetic iron oxide nanoparticles could be successfully coated with two polymers (PEG and PVA) and gallic acid as an active drug. Release behavior of gallic acid from two nanocomposites showed that FPEGG and FPVAG nanocomposites were found to be sustained and governed by pseudo-second-order kinetics. Anticancer activity of the two nanocomposites shows that the FPEGG demonstrated higher anticancer effect on the breast cancer cell lines in almost all concentrations tested compared to FPVAG. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34152/1/In%20Vitro%20Sustained%20Release%20Study%20of%20Gallic%20Acid%20Coated%20with.pdf Dorniani, Dena and Kura, Aminu Umar and Hussein-Al-Ali, Samer Hasan and Hussein, Mohd Zobir and Fakurazi, Sharida and Shaari, Abdul Halim and Ahmad, Zalinah (2014) In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system. The Scientific World Journal, 2014. art. no. 416354. pp. 1-11. ISSN 2356-6140; ESSN: 1537-744X http://www.hindawi.com/journals/tswj/2014/416354/ 10.1155/2014/416354 |
| spellingShingle | Dorniani, Dena Kura, Aminu Umar Hussein-Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system |
| title | In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system |
| title_full | In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system |
| title_fullStr | In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system |
| title_full_unstemmed | In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system |
| title_short | In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system |
| title_sort | in vitro sustained release study of gallic acid coated with magnetite peg and magnetite pva for drug delivery system |
| url | http://psasir.upm.edu.my/id/eprint/34152/1/In%20Vitro%20Sustained%20Release%20Study%20of%20Gallic%20Acid%20Coated%20with.pdf |
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