Mechanisms of action and efficacy of statins against influenza
The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34479/1/Mechanisms%20of%20Action%20and%20Efficacy%20of%20Statins%20against%20Influenza.pdf |
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| author | Mehrbod, Parvaneh Omar, Abdul Rahman Bejo, Mohd Hair Haghani, Amin Ideris, Aini |
| author_facet | Mehrbod, Parvaneh Omar, Abdul Rahman Bejo, Mohd Hair Haghani, Amin Ideris, Aini |
| author_sort | Mehrbod, Parvaneh |
| collection | UPM |
| description | The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinflammatory cytokines. Scientists have reported that anti-inflammatory drugs, with pleiotropic effects, reduce the burden of severe influenza diseases. Therefore, statins, which are cardioprotective drugs with anti-inflammatory and immunomodulatory effects, may help patients suffering from influenza virus (IV). This review delineates the potential use of statins as an alternative therapy in treating influenza related illness. |
| first_indexed | 2024-03-06T08:29:07Z |
| format | Article |
| id | upm.eprints-34479 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:29:07Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | upm.eprints-344792015-12-15T04:51:16Z http://psasir.upm.edu.my/id/eprint/34479/ Mechanisms of action and efficacy of statins against influenza Mehrbod, Parvaneh Omar, Abdul Rahman Bejo, Mohd Hair Haghani, Amin Ideris, Aini The influenza virus (IV) is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system. Public health concerns about clinical efficacy of all conventional drugs are ambiguous; therefore, finding additional therapeutic agents is critical to prevent and control influenza outbreaks. Influenza is associated with the induction of proinflammatory cytokines. Scientists have reported that anti-inflammatory drugs, with pleiotropic effects, reduce the burden of severe influenza diseases. Therefore, statins, which are cardioprotective drugs with anti-inflammatory and immunomodulatory effects, may help patients suffering from influenza virus (IV). This review delineates the potential use of statins as an alternative therapy in treating influenza related illness. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34479/1/Mechanisms%20of%20Action%20and%20Efficacy%20of%20Statins%20against%20Influenza.pdf Mehrbod, Parvaneh and Omar, Abdul Rahman and Bejo, Mohd Hair and Haghani, Amin and Ideris, Aini (2014) Mechanisms of action and efficacy of statins against influenza. BioMed Research International, 2014 . art. no. 872370. pp. 1-8. ISSN 2314-6133; ESSN: 2314-6141 http://www.hindawi.com/journals/bmri/2014/872370/abs/ 10.1155/2014/872370 |
| spellingShingle | Mehrbod, Parvaneh Omar, Abdul Rahman Bejo, Mohd Hair Haghani, Amin Ideris, Aini Mechanisms of action and efficacy of statins against influenza |
| title | Mechanisms of action and efficacy of statins against influenza |
| title_full | Mechanisms of action and efficacy of statins against influenza |
| title_fullStr | Mechanisms of action and efficacy of statins against influenza |
| title_full_unstemmed | Mechanisms of action and efficacy of statins against influenza |
| title_short | Mechanisms of action and efficacy of statins against influenza |
| title_sort | mechanisms of action and efficacy of statins against influenza |
| url | http://psasir.upm.edu.my/id/eprint/34479/1/Mechanisms%20of%20Action%20and%20Efficacy%20of%20Statins%20against%20Influenza.pdf |
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