Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocompo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35016/1/Preparation%20of%20Tween%2080-Zn%20Al-Levodopa-Layered%20Double.pdf |
| _version_ | 1796972621669072896 |
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| author | Kura, Aminu Umar Hussein Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida |
| author_facet | Kura, Aminu Umar Hussein Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida |
| author_sort | Kura, Aminu Umar |
| collection | UPM |
| description | We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay). |
| first_indexed | 2024-03-06T08:31:01Z |
| format | Article |
| id | upm.eprints-35016 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:31:01Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | upm.eprints-350162015-12-28T08:59:32Z http://psasir.upm.edu.my/id/eprint/35016/ Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system Kura, Aminu Umar Hussein Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating process on the dopa release from Tween-dopa-LDH nanocomposite was also studied. The release from Tween-dopa-LDH nanocomposite shows slower release compared to the release of the drug from dopa-LDH nanocomposite as done previously in our study, presumably due to the retarding shielding effect. The cell viability study using PC12 showed improved viability with Tween-80 coating on dopa-LDH nanocomposite as studied by mitochondrial dehydrogenase activity (MTT assay). Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35016/1/Preparation%20of%20Tween%2080-Zn%20Al-Levodopa-Layered%20Double.pdf Kura, Aminu Umar and Hussein Al-Ali, Samer Hasan and Hussein, Mohd Zobir and Fakurazi, Sharida (2014) Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system. The Scientific World Journal, 2014. art. no. 104246. pp. 1-10. ISSN 2356-6140; ESSN: 1537-744X http://www.hindawi.com/journals/tswj/2014/104246/abs/ 10.1155/2014/104246 |
| spellingShingle | Kura, Aminu Umar Hussein Al-Ali, Samer Hasan Hussein, Mohd Zobir Fakurazi, Sharida Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system |
| title | Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system |
| title_full | Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system |
| title_fullStr | Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system |
| title_full_unstemmed | Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system |
| title_short | Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system |
| title_sort | preparation of tween 80 zn al levodopa layered double hydroxides nanocomposite for drug delivery system |
| url | http://psasir.upm.edu.my/id/eprint/35016/1/Preparation%20of%20Tween%2080-Zn%20Al-Levodopa-Layered%20Double.pdf |
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