Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro
An isomeric mixture of α,β-amyrin (triterpene) and 2-methoxy-6-undecyl-1,4-benzoquinone (quinone) isolated from the Ardisia crispa root hexane (ACRH) extract was reported to possess anti-inflammatory properties in vivo. Considering the close association between inflammation and cancer, on top of the...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35560/1/Synergistic%20action%20of%20compounds%20isolated%20from%20the%20hexane%20extract%20of%20Ardisia%20crispa%20root%20against%20tumour-promoting%20effect%2C%20in%20vitro.pdf |
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| author | Yeong, Looi Ting Abd Hamid @ Abdul Razak, Roslida Saiful Yazan, Latifah Khaza'ai, Huzwah Awang Hamsin, Dayang Erna Zulaikha |
| author_facet | Yeong, Looi Ting Abd Hamid @ Abdul Razak, Roslida Saiful Yazan, Latifah Khaza'ai, Huzwah Awang Hamsin, Dayang Erna Zulaikha |
| author_sort | Yeong, Looi Ting |
| collection | UPM |
| description | An isomeric mixture of α,β-amyrin (triterpene) and 2-methoxy-6-undecyl-1,4-benzoquinone (quinone) isolated from the Ardisia crispa root hexane (ACRH) extract was reported to possess anti-inflammatory properties in vivo. Considering the close association between inflammation and cancer, on top of the lack of antitumour study on those compounds, this study aimed to determine the potential of both compounds against tumour promotion in vitro, either as single agent or in combination. Triterpene and quinone compounds, as well as triterpene–quinone fraction (TQF) and ACRH were subjected to inhibition of Epstein–Barr virus-early antigen (EBV-EA) activation assay for that purpose. Compared with curcumin (positive control), inhibition against EBV-EA activation occurred in the order: ACRH>TQF ≥ curcumin>α,β-amyrin ≥ 2-methoxy-6-undecyl-1,4-benzoquinone. These findings reported, for the first time, the antitumor-promoting effect of α,β-amyrin and 2-methoxy-6-undecyl-1,4-benzoquinone from the roots of A. crispa, which was enhanced when both compounds act in synergy. |
| first_indexed | 2024-03-06T08:32:42Z |
| format | Article |
| id | upm.eprints-35560 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:32:42Z |
| publishDate | 2014 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | upm.eprints-355602016-10-31T02:10:17Z http://psasir.upm.edu.my/id/eprint/35560/ Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro Yeong, Looi Ting Abd Hamid @ Abdul Razak, Roslida Saiful Yazan, Latifah Khaza'ai, Huzwah Awang Hamsin, Dayang Erna Zulaikha An isomeric mixture of α,β-amyrin (triterpene) and 2-methoxy-6-undecyl-1,4-benzoquinone (quinone) isolated from the Ardisia crispa root hexane (ACRH) extract was reported to possess anti-inflammatory properties in vivo. Considering the close association between inflammation and cancer, on top of the lack of antitumour study on those compounds, this study aimed to determine the potential of both compounds against tumour promotion in vitro, either as single agent or in combination. Triterpene and quinone compounds, as well as triterpene–quinone fraction (TQF) and ACRH were subjected to inhibition of Epstein–Barr virus-early antigen (EBV-EA) activation assay for that purpose. Compared with curcumin (positive control), inhibition against EBV-EA activation occurred in the order: ACRH>TQF ≥ curcumin>α,β-amyrin ≥ 2-methoxy-6-undecyl-1,4-benzoquinone. These findings reported, for the first time, the antitumor-promoting effect of α,β-amyrin and 2-methoxy-6-undecyl-1,4-benzoquinone from the roots of A. crispa, which was enhanced when both compounds act in synergy. Taylor & Francis 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35560/1/Synergistic%20action%20of%20compounds%20isolated%20from%20the%20hexane%20extract%20of%20Ardisia%20crispa%20root%20against%20tumour-promoting%20effect%2C%20in%20vitro.pdf Yeong, Looi Ting and Abd Hamid @ Abdul Razak, Roslida and Saiful Yazan, Latifah and Khaza'ai, Huzwah and Awang Hamsin, Dayang Erna Zulaikha (2014) Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro. Natural Product Research, 28 (22). pp. 2026-2030. ISSN 1478-6419; ESSN: 1478-6427 http://www.tandfonline.com/doi/abs/10.1080/14786419.2014.917415?journalCode=gnpl20 10.1080/14786419.2014.917415 |
| spellingShingle | Yeong, Looi Ting Abd Hamid @ Abdul Razak, Roslida Saiful Yazan, Latifah Khaza'ai, Huzwah Awang Hamsin, Dayang Erna Zulaikha Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro |
| title | Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro |
| title_full | Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro |
| title_fullStr | Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro |
| title_full_unstemmed | Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro |
| title_short | Synergistic action of compounds isolated from the hexane extract of Ardisia crispa root against tumour-promoting effect, in vitro |
| title_sort | synergistic action of compounds isolated from the hexane extract of ardisia crispa root against tumour promoting effect in vitro |
| url | http://psasir.upm.edu.my/id/eprint/35560/1/Synergistic%20action%20of%20compounds%20isolated%20from%20the%20hexane%20extract%20of%20Ardisia%20crispa%20root%20against%20tumour-promoting%20effect%2C%20in%20vitro.pdf |
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