Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learni...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/35883/1/Transcriptional%20profiling%20of%20the%20postnatal%20brain%20of%20the%20Ts1Cje%20mouse.pdf |
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| author | Tan, Kai Leng Ling, King Hwa Hewitt, Chelsee A. Cheah , Pike See Simpson, Ken M. Gordon, Lavinia Pritchard, Melanie A. Smyth, Gordon K. Thomas, Tim Scott, Hamish S. |
| author_facet | Tan, Kai Leng Ling, King Hwa Hewitt, Chelsee A. Cheah , Pike See Simpson, Ken M. Gordon, Lavinia Pritchard, Melanie A. Smyth, Gordon K. Thomas, Tim Scott, Hamish S. |
| author_sort | Tan, Kai Leng |
| collection | UPM |
| description | The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learning and memory [2] and [3]. To understand the global gene expression effect of the partially triplicated MMU16 segment on mouse brain development, we performed the spatiotemporal transcriptome analysis of Ts1Cje and disomic control cerebral cortex, cerebellum and hippocampus harvested at four developmental time-points: postnatal day (P)1, P15, P30 and P84. Here, we provide a detailed description of the experimental and analysis procedures of the microarray dataset, which has been deposited in the Gene Expression Omnibus (GSE49050) database. |
| first_indexed | 2024-03-06T08:33:40Z |
| format | Article |
| id | upm.eprints-35883 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:33:40Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-358832016-02-11T04:44:57Z http://psasir.upm.edu.my/id/eprint/35883/ Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome Tan, Kai Leng Ling, King Hwa Hewitt, Chelsee A. Cheah , Pike See Simpson, Ken M. Gordon, Lavinia Pritchard, Melanie A. Smyth, Gordon K. Thomas, Tim Scott, Hamish S. The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learning and memory [2] and [3]. To understand the global gene expression effect of the partially triplicated MMU16 segment on mouse brain development, we performed the spatiotemporal transcriptome analysis of Ts1Cje and disomic control cerebral cortex, cerebellum and hippocampus harvested at four developmental time-points: postnatal day (P)1, P15, P30 and P84. Here, we provide a detailed description of the experimental and analysis procedures of the microarray dataset, which has been deposited in the Gene Expression Omnibus (GSE49050) database. Elsevier 2014-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/35883/1/Transcriptional%20profiling%20of%20the%20postnatal%20brain%20of%20the%20Ts1Cje%20mouse.pdf Tan, Kai Leng and Ling, King Hwa and Hewitt, Chelsee A. and Cheah , Pike See and Simpson, Ken M. and Gordon, Lavinia and Pritchard, Melanie A. and Smyth, Gordon K. and Thomas, Tim and Scott, Hamish S. (2014) Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome. Genomics Data, 2. pp. 314-317. ISSN 2213-5960 http://www.sciencedirect.com/science/article/pii/S2213596014000841 10.1016/j.gdata.2014.09.009 |
| spellingShingle | Tan, Kai Leng Ling, King Hwa Hewitt, Chelsee A. Cheah , Pike See Simpson, Ken M. Gordon, Lavinia Pritchard, Melanie A. Smyth, Gordon K. Thomas, Tim Scott, Hamish S. Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome |
| title | Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome |
| title_full | Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome |
| title_fullStr | Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome |
| title_full_unstemmed | Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome |
| title_short | Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome |
| title_sort | transcriptional profiling of the postnatal brain of the ts1cje mouse model of down syndrome |
| url | http://psasir.upm.edu.my/id/eprint/35883/1/Transcriptional%20profiling%20of%20the%20postnatal%20brain%20of%20the%20Ts1Cje%20mouse.pdf |
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