A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway

A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway

The compound with R = CH2CH3 in Bi(S2CNR2)3 (1) is highly cytotoxic against a range of human carcinoma, whereas that with R = CH2CH2OH (2) is considerably less so. Both 1 and 2 induce apoptosis in HepG2 cells with some evidence for necrosis induced by 2. Based on DNA fragmentation, caspase activitie...

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Bibliographic Details
Main Authors: Abang Ishak, Dayang Hazwani, Ooi, Kah Kooi, Ang, Kok Pian, Md. Akim, Abdah, Cheah, Yoke Kqueen, Nordin, Norshariza, Abdul Halim, Siti Nadiah, Seng, Hoi Ling, Tiekink, Edward R. T.
Format: Article
Language:English
Published: Elsevier 2014
Online Access:http://psasir.upm.edu.my/id/eprint/36121/1/A%20bismuth%20diethyldithiocarbamate%20compound%20promotes%20apoptosis%20in%20HepG2%20carcinoma.pdf

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