Innovations in MDR therapy: essential oil applications
There are three common outcomes when testing the application of combinatory therapies for potential use in the clinical setting against multi-drug resistant (MDR) bacteria; whether synergistic, additive or antagonistic. Due to their relatively more favourable outcomes, antibiotics and adjuvant achie...
| Main Authors: | , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
IEEE
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36315/1/Innovations%20in%20MDR%20therapy%20essential%20oil%20applications.pdf |
| _version_ | 1825948817520852992 |
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| author | Yang, Shun Kai Alhosani, Maryam Sultan Lim, Erin Swee Hua Akseer, Riaz Abushelaibi, Aisha Lai, Kok Song |
| author_facet | Yang, Shun Kai Alhosani, Maryam Sultan Lim, Erin Swee Hua Akseer, Riaz Abushelaibi, Aisha Lai, Kok Song |
| author_sort | Yang, Shun Kai |
| collection | UPM |
| description | There are three common outcomes when testing the application of combinatory therapies for potential use in the clinical setting against multi-drug resistant (MDR) bacteria; whether synergistic, additive or antagonistic. Due to their relatively more favourable outcomes, antibiotics and adjuvant achieving synergism have been the primary focus in the development of therapeutics thus far; this has also resulted in less attention given to additive interactions, which may be equally effective. Hence, in this study, the authors investigated the effects of additivity using a representative combination model involving Cinnamomum verum (cinnamon bark) essential oil (CBO) and meropenem, a carbapenem class of antibiotics. Based on the zeta potential measurements, outer membrane permeability and scanning electron microscopy, synergistic and additive interactions of cinnamon bark oil (CBO) indicated comparable bacterial membrane disruption, alluding similar degrees of cell perturbations at the molecular level. Results from this study suggests that further investigations should be looked into for combinatorial therapeutic pairs achieving additive indices so as not to disqualify potentially useful alternatives in antibiotic therapy. |
| first_indexed | 2024-03-06T08:34:57Z |
| format | Conference or Workshop Item |
| id | upm.eprints-36315 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:34:57Z |
| publishDate | 2019 |
| publisher | IEEE |
| record_format | dspace |
| spelling | upm.eprints-363152020-06-15T07:49:18Z http://psasir.upm.edu.my/id/eprint/36315/ Innovations in MDR therapy: essential oil applications Yang, Shun Kai Alhosani, Maryam Sultan Lim, Erin Swee Hua Akseer, Riaz Abushelaibi, Aisha Lai, Kok Song There are three common outcomes when testing the application of combinatory therapies for potential use in the clinical setting against multi-drug resistant (MDR) bacteria; whether synergistic, additive or antagonistic. Due to their relatively more favourable outcomes, antibiotics and adjuvant achieving synergism have been the primary focus in the development of therapeutics thus far; this has also resulted in less attention given to additive interactions, which may be equally effective. Hence, in this study, the authors investigated the effects of additivity using a representative combination model involving Cinnamomum verum (cinnamon bark) essential oil (CBO) and meropenem, a carbapenem class of antibiotics. Based on the zeta potential measurements, outer membrane permeability and scanning electron microscopy, synergistic and additive interactions of cinnamon bark oil (CBO) indicated comparable bacterial membrane disruption, alluding similar degrees of cell perturbations at the molecular level. Results from this study suggests that further investigations should be looked into for combinatorial therapeutic pairs achieving additive indices so as not to disqualify potentially useful alternatives in antibiotic therapy. IEEE 2019 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/36315/1/Innovations%20in%20MDR%20therapy%20essential%20oil%20applications.pdf Yang, Shun Kai and Alhosani, Maryam Sultan and Lim, Erin Swee Hua and Akseer, Riaz and Abushelaibi, Aisha and Lai, Kok Song (2019) Innovations in MDR therapy: essential oil applications. In: 2019 Advances in Science and Engineering Technology International Conferences (ASET 2019), 26 Mar.-10 Apr. 2019, Dubai, United Arab Emirates. . 10.1109/ICASET.2019.8714399 |
| spellingShingle | Yang, Shun Kai Alhosani, Maryam Sultan Lim, Erin Swee Hua Akseer, Riaz Abushelaibi, Aisha Lai, Kok Song Innovations in MDR therapy: essential oil applications |
| title | Innovations in MDR therapy: essential oil applications |
| title_full | Innovations in MDR therapy: essential oil applications |
| title_fullStr | Innovations in MDR therapy: essential oil applications |
| title_full_unstemmed | Innovations in MDR therapy: essential oil applications |
| title_short | Innovations in MDR therapy: essential oil applications |
| title_sort | innovations in mdr therapy essential oil applications |
| url | http://psasir.upm.edu.my/id/eprint/36315/1/Innovations%20in%20MDR%20therapy%20essential%20oil%20applications.pdf |
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