Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats
The oral acute toxicity of the aqueous peppermint extract (APE) was assessed and the bio and/or chemo markers for hypocholesterolemic activity of APE were identified through metabolomics approach. No mortality resulted from the present oral acute toxicity study in which the histological changes obse...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Healthy-Synergies Publications
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36325/1/Acute%20toxicity%20and%20metabolomics%20analysis%20of%20hypocholesterolemic%20effect%20of%20Mentha%20piperita%20aqueous%20extract%20in%20Wistar%20rats.pdf |
| _version_ | 1825948819449184256 |
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| author | Johari, Nor Zaini Ismail, Intan Safinar Sulaiman, Mohd Roslan Abas, Faridah Shaari, Khozirah |
| author_facet | Johari, Nor Zaini Ismail, Intan Safinar Sulaiman, Mohd Roslan Abas, Faridah Shaari, Khozirah |
| author_sort | Johari, Nor Zaini |
| collection | UPM |
| description | The oral acute toxicity of the aqueous peppermint extract (APE) was assessed and the bio and/or chemo markers for hypocholesterolemic activity of APE were identified through metabolomics approach. No mortality resulted from the present oral acute toxicity study in which the histological changes observed in the selected organs and the biochemical deviation of blood compared to the normal range level were minimal. This study also explored the effect of 290 mg-1 kg body weight of APE against 5% cholesterol-enriched diet within 14 days treatment. Whereby after the treatment, there were reductions exhibited in plasma total cholesterol (44.32%), LDL-cholesterol (69.19%) and total triglycerides (55.77%). 1H NMR-metabolomics approach was, employed for better sensitivity and accuracy in evaluating the potential plasma biomarkers of hyper-and hypo-cholesterolemic properties. β-Hydroxybutarate and α-D-glucose have been identified as the possible hypercholesterolemic markers, whereas taurine, betaine, alanine, glycine and L-leucine were suggested to be the hypocholesterolemic markers of APE. |
| first_indexed | 2024-03-06T08:34:59Z |
| format | Article |
| id | upm.eprints-36325 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:34:59Z |
| publishDate | 2015 |
| publisher | Healthy-Synergies Publications |
| record_format | dspace |
| spelling | upm.eprints-363252015-10-05T00:27:57Z http://psasir.upm.edu.my/id/eprint/36325/ Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats Johari, Nor Zaini Ismail, Intan Safinar Sulaiman, Mohd Roslan Abas, Faridah Shaari, Khozirah The oral acute toxicity of the aqueous peppermint extract (APE) was assessed and the bio and/or chemo markers for hypocholesterolemic activity of APE were identified through metabolomics approach. No mortality resulted from the present oral acute toxicity study in which the histological changes observed in the selected organs and the biochemical deviation of blood compared to the normal range level were minimal. This study also explored the effect of 290 mg-1 kg body weight of APE against 5% cholesterol-enriched diet within 14 days treatment. Whereby after the treatment, there were reductions exhibited in plasma total cholesterol (44.32%), LDL-cholesterol (69.19%) and total triglycerides (55.77%). 1H NMR-metabolomics approach was, employed for better sensitivity and accuracy in evaluating the potential plasma biomarkers of hyper-and hypo-cholesterolemic properties. β-Hydroxybutarate and α-D-glucose have been identified as the possible hypercholesterolemic markers, whereas taurine, betaine, alanine, glycine and L-leucine were suggested to be the hypocholesterolemic markers of APE. Healthy-Synergies Publications 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36325/1/Acute%20toxicity%20and%20metabolomics%20analysis%20of%20hypocholesterolemic%20effect%20of%20Mentha%20piperita%20aqueous%20extract%20in%20Wistar%20rats.pdf Johari, Nor Zaini and Ismail, Intan Safinar and Sulaiman, Mohd Roslan and Abas, Faridah and Shaari, Khozirah (2015) Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats. International Journal of Applied Research in Natural Products, 8 (1). pp. 1-11. ISSN 1940-6223 http://www.ijarnp.org/index.php/ijarnp/article/view/269 |
| spellingShingle | Johari, Nor Zaini Ismail, Intan Safinar Sulaiman, Mohd Roslan Abas, Faridah Shaari, Khozirah Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats |
| title | Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats |
| title_full | Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats |
| title_fullStr | Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats |
| title_full_unstemmed | Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats |
| title_short | Acute toxicity and metabolomics analysis of hypocholesterolemic effect of Mentha piperita aqueous extract in Wistar rats |
| title_sort | acute toxicity and metabolomics analysis of hypocholesterolemic effect of mentha piperita aqueous extract in wistar rats |
| url | http://psasir.upm.edu.my/id/eprint/36325/1/Acute%20toxicity%20and%20metabolomics%20analysis%20of%20hypocholesterolemic%20effect%20of%20Mentha%20piperita%20aqueous%20extract%20in%20Wistar%20rats.pdf |
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