Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts
The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibro- blast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analy...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centro Regional de Investigaciones Cientificas y Tecnologicas
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/36461/1/Angiotensin%20II%20stimulates%20expression%20of%20transcription%20factors%20c.pdf |
| _version_ | 1825948846200455168 |
|---|---|
| author | Subramani, Tamilselvan Rao, Suresh Senthilkumar, Kamatchiammal Perisamy, Saundararajan Mohamed Alitheen, Noorjahan Banu |
| author_facet | Subramani, Tamilselvan Rao, Suresh Senthilkumar, Kamatchiammal Perisamy, Saundararajan Mohamed Alitheen, Noorjahan Banu |
| author_sort | Subramani, Tamilselvan |
| collection | UPM |
| description | The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibro- blast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells. |
| first_indexed | 2024-03-06T08:35:23Z |
| format | Article |
| id | upm.eprints-36461 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:35:23Z |
| publishDate | 2014 |
| publisher | Centro Regional de Investigaciones Cientificas y Tecnologicas |
| record_format | dspace |
| spelling | upm.eprints-364612016-01-26T07:38:23Z http://psasir.upm.edu.my/id/eprint/36461/ Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts Subramani, Tamilselvan Rao, Suresh Senthilkumar, Kamatchiammal Perisamy, Saundararajan Mohamed Alitheen, Noorjahan Banu The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibro- blast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells. Centro Regional de Investigaciones Cientificas y Tecnologicas 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36461/1/Angiotensin%20II%20stimulates%20expression%20of%20transcription%20factors%20c.pdf Subramani, Tamilselvan and Rao, Suresh and Senthilkumar, Kamatchiammal and Perisamy, Saundararajan and Mohamed Alitheen, Noorjahan Banu (2014) Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts. Biocell, 37 (3). pp. 71-76. ISSN 0327-9545; ESSN: 1667-5746 http://www.cricyt.edu.ar/biocell/vol/37_3.html |
| spellingShingle | Subramani, Tamilselvan Rao, Suresh Senthilkumar, Kamatchiammal Perisamy, Saundararajan Mohamed Alitheen, Noorjahan Banu Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts |
| title | Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts |
| title_full | Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts |
| title_fullStr | Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts |
| title_full_unstemmed | Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts |
| title_short | Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts |
| title_sort | angiotensin ii stimulates expression of transcription factors c jun and c fos in cyclosporine induced human gingival fibroblasts |
| url | http://psasir.upm.edu.my/id/eprint/36461/1/Angiotensin%20II%20stimulates%20expression%20of%20transcription%20factors%20c.pdf |
| work_keys_str_mv | AT subramanitamilselvan angiotensiniistimulatesexpressionoftranscriptionfactorscjunandcfosincyclosporineinducedhumangingivalfibroblasts AT raosuresh angiotensiniistimulatesexpressionoftranscriptionfactorscjunandcfosincyclosporineinducedhumangingivalfibroblasts AT senthilkumarkamatchiammal angiotensiniistimulatesexpressionoftranscriptionfactorscjunandcfosincyclosporineinducedhumangingivalfibroblasts AT perisamysaundararajan angiotensiniistimulatesexpressionoftranscriptionfactorscjunandcfosincyclosporineinducedhumangingivalfibroblasts AT mohamedalitheennoorjahanbanu angiotensiniistimulatesexpressionoftranscriptionfactorscjunandcfosincyclosporineinducedhumangingivalfibroblasts |