Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract
Evaluation of anti-inflammatory and antinociceptive activities of untreated mung bean (MB), germinated mung bean (GMB), and fermented mung bean (FMB) was performed on both in vitro (inhibition of inflammatory mediator, nitric oxide(NO)) and in vivo (inhibition of ear oedema and reduction of response...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36476/1/Anti.pdf |
| _version_ | 1796972920236408832 |
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| author | Mohd Ali, Norlaily Mohd Yusof, Hamidah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Long, Kamariah Koh, Soo Peng Abdullah, Mohd Puad Mohamed Alitheen, Noorjahan Banu |
| author_facet | Mohd Ali, Norlaily Mohd Yusof, Hamidah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Long, Kamariah Koh, Soo Peng Abdullah, Mohd Puad Mohamed Alitheen, Noorjahan Banu |
| author_sort | Mohd Ali, Norlaily |
| collection | UPM |
| description | Evaluation of anti-inflammatory and antinociceptive activities of untreated mung bean (MB), germinated mung bean (GMB), and fermented mung bean (FMB) was performed on both in vitro (inhibition of inflammatory mediator, nitric oxide(NO)) and in vivo (inhibition of ear oedema and reduction of response to pain stimulus) studies. Results showed that both GMB and FMB aqueous extract exhibited potent anti-inflammatory and antinociceptive activities in a dose-dependent manner. In vitro results showed that GMB and FMB were potent inflammatory mediator (NO) inhibitors at both 2.5 and 5 mg/mL. Further in vivo studies showed that GMB and FMB aqueous extract at 1000 mg/kg can significantly reduce ear oedema in mice caused by arachidonic acid. Besides, both 200 mg/kg and 1000 mg/kg concentrations of GMB and FMB were found to exhibit potent antinociceptive effects towards hotplate induced pain. With these, it can be concluded that GMB and FMB aqueous extract exhibited potential anti-inflammatory and antinociceptive effects. |
| first_indexed | 2024-03-06T08:35:26Z |
| format | Article |
| id | upm.eprints-36476 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:35:26Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | upm.eprints-364762015-10-06T04:31:27Z http://psasir.upm.edu.my/id/eprint/36476/ Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract Mohd Ali, Norlaily Mohd Yusof, Hamidah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Long, Kamariah Koh, Soo Peng Abdullah, Mohd Puad Mohamed Alitheen, Noorjahan Banu Evaluation of anti-inflammatory and antinociceptive activities of untreated mung bean (MB), germinated mung bean (GMB), and fermented mung bean (FMB) was performed on both in vitro (inhibition of inflammatory mediator, nitric oxide(NO)) and in vivo (inhibition of ear oedema and reduction of response to pain stimulus) studies. Results showed that both GMB and FMB aqueous extract exhibited potent anti-inflammatory and antinociceptive activities in a dose-dependent manner. In vitro results showed that GMB and FMB were potent inflammatory mediator (NO) inhibitors at both 2.5 and 5 mg/mL. Further in vivo studies showed that GMB and FMB aqueous extract at 1000 mg/kg can significantly reduce ear oedema in mice caused by arachidonic acid. Besides, both 200 mg/kg and 1000 mg/kg concentrations of GMB and FMB were found to exhibit potent antinociceptive effects towards hotplate induced pain. With these, it can be concluded that GMB and FMB aqueous extract exhibited potential anti-inflammatory and antinociceptive effects. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36476/1/Anti.pdf Mohd Ali, Norlaily and Mohd Yusof, Hamidah and Yeap, Swee Keong and Ho, Wan Yong and Beh, Boon Kee and Long, Kamariah and Koh, Soo Peng and Abdullah, Mohd Puad and Mohamed Alitheen, Noorjahan Banu (2014) Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract. Evidence-Based Complementary and Alternative Medicine, 2014. art. no. 350507. pp. 1-6. ISSN 1741-427X; ESSN: 1741-4288 http://www.hindawi.com/journals/ecam/2014/350507/ 10.1155/2014/350507 |
| spellingShingle | Mohd Ali, Norlaily Mohd Yusof, Hamidah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Long, Kamariah Koh, Soo Peng Abdullah, Mohd Puad Mohamed Alitheen, Noorjahan Banu Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract |
| title | Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract |
| title_full | Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract |
| title_fullStr | Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract |
| title_full_unstemmed | Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract |
| title_short | Anti-inflammatory and Antinociceptive activities of untreated, germinated and fermented mung bean aqueous extract |
| title_sort | anti inflammatory and antinociceptive activities of untreated germinated and fermented mung bean aqueous extract |
| url | http://psasir.upm.edu.my/id/eprint/36476/1/Anti.pdf |
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