Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents
Hydroxamic acids, fatty hydroxamic acids and their metal complexes are known as compounds that have biological activity. They have been investigated as antimicrobial compounds and were applied as antibacterial and antifungal agents in pharmacy andpharmaceutical compounds. In this research, the methy...
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| Format: | Article |
| Language: | English |
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Academy of Romanian Scientists
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36515/1/Application%20of%20methyl%20fatty%20hydroxamic%20acids%20based%20on%20Jatropha%20curcas%20seed%20oil%20and%20their%20metal%20complexes%20as%20anti%20microbial%20agents.pdf |
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| author | Rafiee-Moghaddam, Roshanak Salimon, Jumat Haron, Md. Jelas Jahangirian, Hossein Ismail, Mohd Halim Shah Afsah-Hejri, Leili Vafaei, Nazanin Tayefehchamani, Yasamin |
| author_facet | Rafiee-Moghaddam, Roshanak Salimon, Jumat Haron, Md. Jelas Jahangirian, Hossein Ismail, Mohd Halim Shah Afsah-Hejri, Leili Vafaei, Nazanin Tayefehchamani, Yasamin |
| author_sort | Rafiee-Moghaddam, Roshanak |
| collection | UPM |
| description | Hydroxamic acids, fatty hydroxamic acids and their metal complexes are known as compounds that have biological activity. They have been investigated as antimicrobial compounds and were applied as antibacterial and antifungal agents in pharmacy andpharmaceutical compounds. In this research, the methyl fatty hydroxamic acids (MFHAs) based on Jatrophacurcas seed oil and their metal complexes include the copper (II) methyl fatty hydroxamate (Cu-MFHs) and iron (III) methyl fatty hydroxamate (Fe-MFHs) were prepared and applied as anti microbial agents against the Escherichia coli (E. coli), Proteus vulgaris (P. vulgaris) andProteus mirabilis (P. mirabilis) as gramnegative bacteria; methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (S. epidermidis) as gram-positive bacteria ; Candida parapsilosis (C. parapsilosis) and Candida Albicans(C. Albicans) as yeast family of fungi. The results showed that the antimicrobial activity of MFHAs, Cu-MFHs and Fe-MFHs increase while their amounts increase. Also metal complexation of MFHAs caused the anti microbial activity arise and this activity is higher for complexation by Cu(II) compared to that of Fe(III). Comparing antimicrobial activity of MFHAs, Cu-MFHs andFe-MFHs based on Jatrophacurcas seed oil with several antibiotic drugs such as ampicillin, chloramphenicol, gentamicin streptomycin, tetracycline and nystatin against the mentioned microbial showed that the Cu-MFHs andFe-MFHs have very strong antimicrobial activity. |
| first_indexed | 2024-03-06T08:35:33Z |
| format | Article |
| id | upm.eprints-36515 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:35:33Z |
| publishDate | 2014 |
| publisher | Academy of Romanian Scientists |
| record_format | dspace |
| spelling | upm.eprints-365152015-10-29T07:32:49Z http://psasir.upm.edu.my/id/eprint/36515/ Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents Rafiee-Moghaddam, Roshanak Salimon, Jumat Haron, Md. Jelas Jahangirian, Hossein Ismail, Mohd Halim Shah Afsah-Hejri, Leili Vafaei, Nazanin Tayefehchamani, Yasamin Hydroxamic acids, fatty hydroxamic acids and their metal complexes are known as compounds that have biological activity. They have been investigated as antimicrobial compounds and were applied as antibacterial and antifungal agents in pharmacy andpharmaceutical compounds. In this research, the methyl fatty hydroxamic acids (MFHAs) based on Jatrophacurcas seed oil and their metal complexes include the copper (II) methyl fatty hydroxamate (Cu-MFHs) and iron (III) methyl fatty hydroxamate (Fe-MFHs) were prepared and applied as anti microbial agents against the Escherichia coli (E. coli), Proteus vulgaris (P. vulgaris) andProteus mirabilis (P. mirabilis) as gramnegative bacteria; methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (S. epidermidis) as gram-positive bacteria ; Candida parapsilosis (C. parapsilosis) and Candida Albicans(C. Albicans) as yeast family of fungi. The results showed that the antimicrobial activity of MFHAs, Cu-MFHs and Fe-MFHs increase while their amounts increase. Also metal complexation of MFHAs caused the anti microbial activity arise and this activity is higher for complexation by Cu(II) compared to that of Fe(III). Comparing antimicrobial activity of MFHAs, Cu-MFHs andFe-MFHs based on Jatrophacurcas seed oil with several antibiotic drugs such as ampicillin, chloramphenicol, gentamicin streptomycin, tetracycline and nystatin against the mentioned microbial showed that the Cu-MFHs andFe-MFHs have very strong antimicrobial activity. Academy of Romanian Scientists 2014-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36515/1/Application%20of%20methyl%20fatty%20hydroxamic%20acids%20based%20on%20Jatropha%20curcas%20seed%20oil%20and%20their%20metal%20complexes%20as%20anti%20microbial%20agents.pdf Rafiee-Moghaddam, Roshanak and Salimon, Jumat and Haron, Md. Jelas and Jahangirian, Hossein and Ismail, Mohd Halim Shah and Afsah-Hejri, Leili and Vafaei, Nazanin and Tayefehchamani, Yasamin (2014) Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents. Digest Journal of Nanomaterials and Biostructures, 9 (1). pp. 261-271. ISSN 1842-3582 http://www.chalcogen.ro/digest.html |
| spellingShingle | Rafiee-Moghaddam, Roshanak Salimon, Jumat Haron, Md. Jelas Jahangirian, Hossein Ismail, Mohd Halim Shah Afsah-Hejri, Leili Vafaei, Nazanin Tayefehchamani, Yasamin Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents |
| title | Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents |
| title_full | Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents |
| title_fullStr | Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents |
| title_full_unstemmed | Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents |
| title_short | Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents |
| title_sort | application of methyl fatty hydroxamic acids based on jatropha curcas seed oil and their metal complexes as anti microbial agents |
| url | http://psasir.upm.edu.my/id/eprint/36515/1/Application%20of%20methyl%20fatty%20hydroxamic%20acids%20based%20on%20Jatropha%20curcas%20seed%20oil%20and%20their%20metal%20complexes%20as%20anti%20microbial%20agents.pdf |
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