Characterization of rice bran wax policosanol and its nanoemulsion formulation
Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different dr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36739/1/Characterization%20of%20rice%20bran%20wax%20policosanol%20and%20its%20nanoemulsion%20formulation.pdf |
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| author | Ishaka, Aminu Imam, Mustapha Umar Mahamud, Rozi Abu Bakar @ Zakaria, Md Zuki Ismail, Maznah |
| author_facet | Ishaka, Aminu Imam, Mustapha Umar Mahamud, Rozi Abu Bakar @ Zakaria, Md Zuki Ismail, Maznah |
| author_sort | Ishaka, Aminu |
| collection | UPM |
| description | Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different droplet size distributions are usually achieved when emulsions are formed, which solely depends on the preparation method used. Mostly, emulsions are intended for better delivery with maintenance of the characteristics and properties of the leading components. In this study, policosanol was extracted from rice bran wax, its composition was determined by gas chromatography mass spectrophotometry, nanoemulsion was made, and the physical stability characteristics were determined. The results showed that policosanol nanoemulsion has a nanosize particle distribution below 100 nm (92.56–94.52 nm), with optimum charge distribution (-55.8 to -45.12 mV), pH (6.79–6.92) and refractive index (1.50); these were monitored and found to be stable for 8 weeks. The stability of policosanol nanoemulsion confers the potential to withstand long storage times. |
| first_indexed | 2024-03-06T08:36:13Z |
| format | Article |
| id | upm.eprints-36739 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:36:13Z |
| publishDate | 2014 |
| publisher | Dove Medical Press |
| record_format | dspace |
| spelling | upm.eprints-367392016-11-21T02:36:11Z http://psasir.upm.edu.my/id/eprint/36739/ Characterization of rice bran wax policosanol and its nanoemulsion formulation Ishaka, Aminu Imam, Mustapha Umar Mahamud, Rozi Abu Bakar @ Zakaria, Md Zuki Ismail, Maznah Policosanol, a mixture of long-chain alcohols found in animal and plant waxes, has several biological effects; however, it has a bioavailability of less than 10%. Therefore, there is a need to improve its bioavailability, and one of the ways of doing this is by nanoemulsion formulation. Different droplet size distributions are usually achieved when emulsions are formed, which solely depends on the preparation method used. Mostly, emulsions are intended for better delivery with maintenance of the characteristics and properties of the leading components. In this study, policosanol was extracted from rice bran wax, its composition was determined by gas chromatography mass spectrophotometry, nanoemulsion was made, and the physical stability characteristics were determined. The results showed that policosanol nanoemulsion has a nanosize particle distribution below 100 nm (92.56–94.52 nm), with optimum charge distribution (-55.8 to -45.12 mV), pH (6.79–6.92) and refractive index (1.50); these were monitored and found to be stable for 8 weeks. The stability of policosanol nanoemulsion confers the potential to withstand long storage times. Dove Medical Press 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36739/1/Characterization%20of%20rice%20bran%20wax%20policosanol%20and%20its%20nanoemulsion%20formulation.pdf Ishaka, Aminu and Imam, Mustapha Umar and Mahamud, Rozi and Abu Bakar @ Zakaria, Md Zuki and Ismail, Maznah (2014) Characterization of rice bran wax policosanol and its nanoemulsion formulation. International Journal of Nanomedicine, 9 (1). pp. 2261-2269. ISSN 1176-9114; ESSN: 1178-2013 http://www.dovepress.com/characterization-of-rice-bran-wax-policosanol-and-its-nanoemulsion-for-peer-reviewed-article-IJN 10.2147/IJN.S56999 |
| spellingShingle | Ishaka, Aminu Imam, Mustapha Umar Mahamud, Rozi Abu Bakar @ Zakaria, Md Zuki Ismail, Maznah Characterization of rice bran wax policosanol and its nanoemulsion formulation |
| title | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
| title_full | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
| title_fullStr | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
| title_full_unstemmed | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
| title_short | Characterization of rice bran wax policosanol and its nanoemulsion formulation |
| title_sort | characterization of rice bran wax policosanol and its nanoemulsion formulation |
| url | http://psasir.upm.edu.my/id/eprint/36739/1/Characterization%20of%20rice%20bran%20wax%20policosanol%20and%20its%20nanoemulsion%20formulation.pdf |
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