Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats
About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were used in this study over a 20 day period. They were allocated randomly into 4 groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was control treated with Gentamycin ointment. Groups 2-4 were treated wi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Medwell Journals
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36808/1/Collagen.pdf |
| _version_ | 1825948913782226944 |
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| author | Khaled, M. A. Abu, Jalila Hashim, Kalthum Mohamed Mustapha, Noordin Saleh, W. Asma |
| author_facet | Khaled, M. A. Abu, Jalila Hashim, Kalthum Mohamed Mustapha, Noordin Saleh, W. Asma |
| author_sort | Khaled, M. A. |
| collection | UPM |
| description | About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were used in this study over a 20 day period. They were allocated randomly into 4 groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was control treated with Gentamycin ointment. Groups 2-4 were treated with Therapeutic ultrasound massage, collagen-calcium alginate film and collagen-calcium alginate film with therapeutic ultrasound. On application, the collagen-calcium alginate film with therapeutic ultrasound was well accepted by the animals without any adverse reaction. Mean percentage of wound contraction were significantly better in group 4 (p<0.05). Faster epithelialization was also seen in the collagen-calcium alginate film with therapeutic ultrasound treated group as compared to the other groups. Collagen is a biocompatible protein that does not interfere with the body’s normal immunologic response and can be used in non-healing chronic wounds which require a trigger to stimulate the normal healing process. In extensive wounds when there is lack of autologous tissue, biomaterials like collagen-calcium alginate may be beneficial and can be used. |
| first_indexed | 2024-03-06T08:36:25Z |
| format | Article |
| id | upm.eprints-36808 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:36:25Z |
| publishDate | 2014 |
| publisher | Medwell Journals |
| record_format | dspace |
| spelling | upm.eprints-368082016-11-21T05:00:17Z http://psasir.upm.edu.my/id/eprint/36808/ Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats Khaled, M. A. Abu, Jalila Hashim, Kalthum Mohamed Mustapha, Noordin Saleh, W. Asma About 24 healthy female Sprague-Dawley rats weighing between 300-350 g were used in this study over a 20 day period. They were allocated randomly into 4 groups of 6 animals each. After the creation of 2x2 cm open wound, group 1 was control treated with Gentamycin ointment. Groups 2-4 were treated with Therapeutic ultrasound massage, collagen-calcium alginate film and collagen-calcium alginate film with therapeutic ultrasound. On application, the collagen-calcium alginate film with therapeutic ultrasound was well accepted by the animals without any adverse reaction. Mean percentage of wound contraction were significantly better in group 4 (p<0.05). Faster epithelialization was also seen in the collagen-calcium alginate film with therapeutic ultrasound treated group as compared to the other groups. Collagen is a biocompatible protein that does not interfere with the body’s normal immunologic response and can be used in non-healing chronic wounds which require a trigger to stimulate the normal healing process. In extensive wounds when there is lack of autologous tissue, biomaterials like collagen-calcium alginate may be beneficial and can be used. Medwell Journals 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36808/1/Collagen.pdf Khaled, M. A. and Abu, Jalila and Hashim, Kalthum and Mohamed Mustapha, Noordin and Saleh, W. Asma (2014) Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats. Research Journal of Biological Sciences, 9 (2). pp. 57-61. ISSN 1815-8846; ESSN: 1993-6087 http://medwelljournals.com/abstract/?doi=rjbsci.2014.57.61 10.3923/rjbsci.2014.57.61 |
| spellingShingle | Khaled, M. A. Abu, Jalila Hashim, Kalthum Mohamed Mustapha, Noordin Saleh, W. Asma Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats |
| title | Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats |
| title_full | Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats |
| title_fullStr | Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats |
| title_full_unstemmed | Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats |
| title_short | Collagen-calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats |
| title_sort | collagen calcium alginate film dressing with therapeutic ultrasound to treat open wound in rats |
| url | http://psasir.upm.edu.my/id/eprint/36808/1/Collagen.pdf |
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