Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene
This research aims to formulate and to optimize a nanoemulsion-based formulation containing fullerene, an antioxidant, stabilized by a low amount of mixed surfactants using high shear and the ultrasonic emulsification method for transdermal delivery. Process parameters optimization of fullerene nano...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/36850/1/Comparison%20of%20process%20parameter%20optimization%20using%20different%20designs%20in%20nanoemulsion%20-%20based%20formulation%20for%20transdermal%20delivery%20of%20fullerene.pdf |
| _version_ | 1825948922070171648 |
|---|---|
| author | Cheng, Loong Ngan Basri, Mahiran Fui, Fang Lye Masoumi, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia |
| author_facet | Cheng, Loong Ngan Basri, Mahiran Fui, Fang Lye Masoumi, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia |
| author_sort | Cheng, Loong Ngan |
| collection | UPM |
| description | This research aims to formulate and to optimize a nanoemulsion-based formulation containing fullerene, an antioxidant, stabilized by a low amount of mixed surfactants using high shear and the ultrasonic emulsification method for transdermal delivery. Process parameters optimization of fullerene nanoemulsions was done by employing response surface methodology, which involved statistical multivariate analysis. Optimization of independent variables was investigated using experimental design based on Box–Behnken design and central composite rotatable design. An investigation on the effect of the homogenization rate (4,000–5,000 rpm), sonication amplitude (20%–60%), and sonication time (30–150 seconds) on the particle size, ζ-potential, and viscosity of the colloidal systems was conducted. Under the optimum conditions, the central composite rotatable design model suggested the response variables for particle size, ζ-potential, and viscosity of the fullerene nanoemulsion were 152.5 nm, –52.6 mV, and 44.6 pascal seconds, respectively. In contrast, the Box–Behnken design model proposed that preparation under the optimum condition would produce nanoemulsion with particle size, ζ-potential, and viscosity of 148.5 nm, –55.2 mV, and 39.9 pascal seconds, respectively. The suggested process parameters to obtain optimum formulation by both models yielded actual response values similar to the predicted values with residual standard error of <2%. The optimum formulation showed more elastic and solid-like characteristics due to the existence of a large linear viscoelastic region. |
| first_indexed | 2024-03-06T08:36:33Z |
| format | Article |
| id | upm.eprints-36850 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:36:33Z |
| publishDate | 2014 |
| publisher | Dove Medical Press |
| record_format | dspace |
| spelling | upm.eprints-368502015-08-21T02:01:43Z http://psasir.upm.edu.my/id/eprint/36850/ Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene Cheng, Loong Ngan Basri, Mahiran Fui, Fang Lye Masoumi, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia This research aims to formulate and to optimize a nanoemulsion-based formulation containing fullerene, an antioxidant, stabilized by a low amount of mixed surfactants using high shear and the ultrasonic emulsification method for transdermal delivery. Process parameters optimization of fullerene nanoemulsions was done by employing response surface methodology, which involved statistical multivariate analysis. Optimization of independent variables was investigated using experimental design based on Box–Behnken design and central composite rotatable design. An investigation on the effect of the homogenization rate (4,000–5,000 rpm), sonication amplitude (20%–60%), and sonication time (30–150 seconds) on the particle size, ζ-potential, and viscosity of the colloidal systems was conducted. Under the optimum conditions, the central composite rotatable design model suggested the response variables for particle size, ζ-potential, and viscosity of the fullerene nanoemulsion were 152.5 nm, –52.6 mV, and 44.6 pascal seconds, respectively. In contrast, the Box–Behnken design model proposed that preparation under the optimum condition would produce nanoemulsion with particle size, ζ-potential, and viscosity of 148.5 nm, –55.2 mV, and 39.9 pascal seconds, respectively. The suggested process parameters to obtain optimum formulation by both models yielded actual response values similar to the predicted values with residual standard error of <2%. The optimum formulation showed more elastic and solid-like characteristics due to the existence of a large linear viscoelastic region. Dove Medical Press 2014-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36850/1/Comparison%20of%20process%20parameter%20optimization%20using%20different%20designs%20in%20nanoemulsion%20-%20based%20formulation%20for%20transdermal%20delivery%20of%20fullerene.pdf Cheng, Loong Ngan and Basri, Mahiran and Fui, Fang Lye and Masoumi, Hamid Reza Fard and Tripathy, Minaketan and Karjiban, Roghayeh Abedi and Abdul Malek, Emilia (2014) Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene. International Journal of Nanomedicine, 9 (1). pp. 4375-4386. ISSN 1176-9114; ESSN: 1178-2013 http://www.dovepress.com/comparison-of-process-parameter-optimization-using-different-designs-i-peer-reviewed-article-IJN 10.2147/IJN.S65689 |
| spellingShingle | Cheng, Loong Ngan Basri, Mahiran Fui, Fang Lye Masoumi, Hamid Reza Fard Tripathy, Minaketan Karjiban, Roghayeh Abedi Abdul Malek, Emilia Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene |
| title | Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene |
| title_full | Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene |
| title_fullStr | Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene |
| title_full_unstemmed | Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene |
| title_short | Comparison of process parameter optimization using different designs in nanoemulsion - based formulation for transdermal delivery of fullerene |
| title_sort | comparison of process parameter optimization using different designs in nanoemulsion based formulation for transdermal delivery of fullerene |
| url | http://psasir.upm.edu.my/id/eprint/36850/1/Comparison%20of%20process%20parameter%20optimization%20using%20different%20designs%20in%20nanoemulsion%20-%20based%20formulation%20for%20transdermal%20delivery%20of%20fullerene.pdf |
| work_keys_str_mv | AT chengloongngan comparisonofprocessparameteroptimizationusingdifferentdesignsinnanoemulsionbasedformulationfortransdermaldeliveryoffullerene AT basrimahiran comparisonofprocessparameteroptimizationusingdifferentdesignsinnanoemulsionbasedformulationfortransdermaldeliveryoffullerene AT fuifanglye comparisonofprocessparameteroptimizationusingdifferentdesignsinnanoemulsionbasedformulationfortransdermaldeliveryoffullerene AT masoumihamidrezafard comparisonofprocessparameteroptimizationusingdifferentdesignsinnanoemulsionbasedformulationfortransdermaldeliveryoffullerene AT tripathyminaketan comparisonofprocessparameteroptimizationusingdifferentdesignsinnanoemulsionbasedformulationfortransdermaldeliveryoffullerene AT karjibanroghayehabedi comparisonofprocessparameteroptimizationusingdifferentdesignsinnanoemulsionbasedformulationfortransdermaldeliveryoffullerene AT abdulmalekemilia comparisonofprocessparameteroptimizationusingdifferentdesignsinnanoemulsionbasedformulationfortransdermaldeliveryoffullerene |