Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines
Objective: To examine the cytotoxic properties of both the kenaf (Hibiscus cannabinus L.) seed extract and kenaf seed oil on human cervical cancer, human breast cancer, human colon cancer and human lung cancer cell lines. Methods: The in vitro cytotoxic activity of the kenaf (Hibiscus cannabinus L.)...
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| Format: | Article |
| Language: | English |
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Asian Pacific Journal of Tropical Biomedicine Editorial Office
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36952/1/Cytotoxic%20activity%20of%20kenaf%20seed%20extract%20and%20oil%20against%20human%20cancer%20cell%20lines.pdf |
| _version_ | 1796973046067625984 |
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| author | Wong, Yu Hua Tan, Wai Yan Tan, Chin Ping Long, Kamariah Nyam, Kar Lin |
| author_facet | Wong, Yu Hua Tan, Wai Yan Tan, Chin Ping Long, Kamariah Nyam, Kar Lin |
| author_sort | Wong, Yu Hua |
| collection | UPM |
| description | Objective: To examine the cytotoxic properties of both the kenaf (Hibiscus cannabinus L.) seed extract and kenaf seed oil on human cervical cancer, human breast cancer, human colon cancer and human lung cancer cell lines. Methods: The in vitro cytotoxic activity of the kenaf (Hibiscus cannabinus L.) seed extract and kenaf seed oil on human cancer cell lines was evaluated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. Cell morphological changes were observed by using an inverted light microscope. Results: The kenaf seed extract (KSE) exhibited a lower IC50 than kenaf seed oil (KSO) in all of the cancer cell lines. Morphological alterations in the cell lines after KSE and KSO treatment were observed. KSE and KSO possessed effective cytotoxic activities against all the cell lines been selected. Conclusions: KSE and KSO could be potential sources of natural anti-cancer agents. Further investigations on using kenaf seeds for anti-proliferative properties are warranted. |
| first_indexed | 2024-03-06T08:36:51Z |
| format | Article |
| id | upm.eprints-36952 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:36:51Z |
| publishDate | 2014 |
| publisher | Asian Pacific Journal of Tropical Biomedicine Editorial Office |
| record_format | dspace |
| spelling | upm.eprints-369522015-10-08T03:31:01Z http://psasir.upm.edu.my/id/eprint/36952/ Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines Wong, Yu Hua Tan, Wai Yan Tan, Chin Ping Long, Kamariah Nyam, Kar Lin Objective: To examine the cytotoxic properties of both the kenaf (Hibiscus cannabinus L.) seed extract and kenaf seed oil on human cervical cancer, human breast cancer, human colon cancer and human lung cancer cell lines. Methods: The in vitro cytotoxic activity of the kenaf (Hibiscus cannabinus L.) seed extract and kenaf seed oil on human cancer cell lines was evaluated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and sulforhodamine B assays. Cell morphological changes were observed by using an inverted light microscope. Results: The kenaf seed extract (KSE) exhibited a lower IC50 than kenaf seed oil (KSO) in all of the cancer cell lines. Morphological alterations in the cell lines after KSE and KSO treatment were observed. KSE and KSO possessed effective cytotoxic activities against all the cell lines been selected. Conclusions: KSE and KSO could be potential sources of natural anti-cancer agents. Further investigations on using kenaf seeds for anti-proliferative properties are warranted. Asian Pacific Journal of Tropical Biomedicine Editorial Office 2014-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/36952/1/Cytotoxic%20activity%20of%20kenaf%20seed%20extract%20and%20oil%20against%20human%20cancer%20cell%20lines.pdf Wong, Yu Hua and Tan, Wai Yan and Tan, Chin Ping and Long, Kamariah and Nyam, Kar Lin (2014) Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines. Asian Pacific Journal of Tropical Biomedicine, 4 (suppl.1). S510-S515. ISSN 2221-1691 http://www.sciencedirect.com/science/article/pii/S2221169115303191 |
| spellingShingle | Wong, Yu Hua Tan, Wai Yan Tan, Chin Ping Long, Kamariah Nyam, Kar Lin Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines |
| title | Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines |
| title_full | Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines |
| title_fullStr | Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines |
| title_full_unstemmed | Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines |
| title_short | Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines |
| title_sort | cytotoxic activity of kenaf hibiscus cannabinus l seed extract and oil against human cancer cell lines |
| url | http://psasir.upm.edu.my/id/eprint/36952/1/Cytotoxic%20activity%20of%20kenaf%20seed%20extract%20and%20oil%20against%20human%20cancer%20cell%20lines.pdf |
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