Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide
The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug iso...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/37053/1/Development%20of%20a%20biocompatible%20nanodelivery%20system%20for%20tuberculosis%20drugs%20based%20on%20isoniazid.pdf |
| _version_ | 1825948961552203776 |
|---|---|
| author | Saifullah, Bullo Arulselvan, Palanisamy El Zowalaty, Mohamed Ezzat Fakurazi, Sharida Webster, Thomas J. Geilich, Benjamin M. Hussein, Mohd Zobir |
| author_facet | Saifullah, Bullo Arulselvan, Palanisamy El Zowalaty, Mohamed Ezzat Fakurazi, Sharida Webster, Thomas J. Geilich, Benjamin M. Hussein, Mohd Zobir |
| author_sort | Saifullah, Bullo |
| collection | UPM |
| description | The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB. |
| first_indexed | 2024-03-06T08:37:09Z |
| format | Article |
| id | upm.eprints-37053 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:37:09Z |
| publishDate | 2014 |
| publisher | Dove Medical Press |
| record_format | dspace |
| spelling | upm.eprints-370532016-01-27T01:13:47Z http://psasir.upm.edu.my/id/eprint/37053/ Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide Saifullah, Bullo Arulselvan, Palanisamy El Zowalaty, Mohamed Ezzat Fakurazi, Sharida Webster, Thomas J. Geilich, Benjamin M. Hussein, Mohd Zobir The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug isoniazid into Mg/Al layered double hydroxides (LDHs). Isoniazid was found to be released in a sustained manner from the novel nanodelivery system in humans in simulated phosphate buffer solutions at pH 4.8 and pH 7.4. The nanodelivery formulation was highly biocompatible compared to free isoniazid against human normal lung and 3T3 mouse fibroblast cells. The formulation was active against Mycobacterium tuberculosis and gram-positive bacteria and gram-negative bacteria. Thus results show significant promise for the further study of these nanocomposites for the treatment of TB. Dove Medical Press 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37053/1/Development%20of%20a%20biocompatible%20nanodelivery%20system%20for%20tuberculosis%20drugs%20based%20on%20isoniazid.pdf Saifullah, Bullo and Arulselvan, Palanisamy and El Zowalaty, Mohamed Ezzat and Fakurazi, Sharida and Webster, Thomas J. and Geilich, Benjamin M. and Hussein, Mohd Zobir (2014) Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide. International Journal of Nanomedicine, 9 (1). pp. 4749-4762. ISSN 1176-9114; ESSN: 1178-2013 http://www.dovepress.com/development-of-a-biocompatible-nanodelivery-system-for-tuberculosis-dr-peer-reviewed-article-IJN 10.2147/IJN.S63608 |
| spellingShingle | Saifullah, Bullo Arulselvan, Palanisamy El Zowalaty, Mohamed Ezzat Fakurazi, Sharida Webster, Thomas J. Geilich, Benjamin M. Hussein, Mohd Zobir Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide |
| title | Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide |
| title_full | Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide |
| title_fullStr | Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide |
| title_full_unstemmed | Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide |
| title_short | Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide |
| title_sort | development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid mg al layered double hydroxide |
| url | http://psasir.upm.edu.my/id/eprint/37053/1/Development%20of%20a%20biocompatible%20nanodelivery%20system%20for%20tuberculosis%20drugs%20based%20on%20isoniazid.pdf |
| work_keys_str_mv | AT saifullahbullo developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT arulselvanpalanisamy developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT elzowalatymohamedezzat developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT fakurazisharida developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT websterthomasj developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT geilichbenjaminm developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide AT husseinmohdzobir developmentofabiocompatiblenanodeliverysystemfortuberculosisdrugsbasedonisoniazidmgallayereddoublehydroxide |