Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia
Background: The number of available reports regarding the influence of ethnicity on clinical features of allergic rhinitis (AR), especially disease severity in tropical climates, is limited. We aimed to compare clinical parameters and disease severity in AR patients of different ethnicities. Meth...
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| 格式: | 文件 |
| 语言: | English |
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Wiley-Blackwell
2014
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| 在线阅读: | http://psasir.upm.edu.my/id/eprint/37503/1/SERUM.pdf |
| _version_ | 1825949046977593344 |
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| author | Amini, Peyman Abdullah, Maha Lee, Sing Seng Karunakaran, Thanusha Norzhafarina Hani Abu Bakar, Saraiza Abdul Latiff, Amir Hamzah Seow, Heng Fong Yap, Yoke Yeow |
| author_facet | Amini, Peyman Abdullah, Maha Lee, Sing Seng Karunakaran, Thanusha Norzhafarina Hani Abu Bakar, Saraiza Abdul Latiff, Amir Hamzah Seow, Heng Fong Yap, Yoke Yeow |
| author_sort | Amini, Peyman |
| collection | UPM |
| description | Background: The number of available reports regarding the influence of ethnicity on clinical features of allergic rhinitis (AR), especially disease severity in tropical climates, is limited. We aimed to compare clinical parameters and disease severity in AR patients of different ethnicities.
Methods: Malay, Chinese, and Indian AR patients (n = 138) with confirmed sensitivity to Dermatophagoides pteronyssinus, Dematophagoides farinae, and Blomia tropicalis were tested for mite-specific immunoglobulin E (sIgE) levels. A detailed questionnaire was used to collect data on nasal symptom score (NSS), ocular symptom score (OSS), sum of symptoms score (SSS), quality of life score (QLS), symptomatic control score (SCS), and total sum of scores (TSS) and correlate the derived data with patients' demography, mite-polysensitivity, and sIgE levels.
Results: AR-related symptoms were most severe in Malays and least in Chinese (p < 0.01). Age (r = 0.516 to 0.673, p < 0.05) and duration of AR (r = 0.635 to 0.726, p < 0.01) correlated positively with severity domains (NSS, SSS, QLS, and TSS) in Chinese. Duration of concurrent allergies was highest in Malays (p < 0.05). Polysensitivity predicted increased sIgE levels in Malays (r = 0.464 to 0.551, p < 0.01) and Indians (r = 0.541 to 0.645, p < 0.05) but affected NSS, SSS, and TSS only in Indians (r = 0.216 to 0.376, p < 0.05). sIgE levels were lowest among Chinese but correlated strongly with NSS, OSS, SSS, and TSS (r = 0408 to 0.898, p < 0.05).
Conclusion: Clinical parameters in AR may be influenced by race. Symptoms were most severe among Malays but did not correlate with other variables examined. Although Indian ethnicity did not impact disease severity, duration of concurrent allergies and mite-polysensitivity was associated with more severe disease. Age, duration of disease, and sIgE levels may be useful indicators of disease severity in Chinese. |
| first_indexed | 2024-03-06T08:38:33Z |
| format | Article |
| id | upm.eprints-37503 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:38:33Z |
| publishDate | 2014 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | upm.eprints-375032021-02-28T17:51:21Z http://psasir.upm.edu.my/id/eprint/37503/ Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia Amini, Peyman Abdullah, Maha Lee, Sing Seng Karunakaran, Thanusha Norzhafarina Hani Abu Bakar, Saraiza Abdul Latiff, Amir Hamzah Seow, Heng Fong Yap, Yoke Yeow Background: The number of available reports regarding the influence of ethnicity on clinical features of allergic rhinitis (AR), especially disease severity in tropical climates, is limited. We aimed to compare clinical parameters and disease severity in AR patients of different ethnicities. Methods: Malay, Chinese, and Indian AR patients (n = 138) with confirmed sensitivity to Dermatophagoides pteronyssinus, Dematophagoides farinae, and Blomia tropicalis were tested for mite-specific immunoglobulin E (sIgE) levels. A detailed questionnaire was used to collect data on nasal symptom score (NSS), ocular symptom score (OSS), sum of symptoms score (SSS), quality of life score (QLS), symptomatic control score (SCS), and total sum of scores (TSS) and correlate the derived data with patients' demography, mite-polysensitivity, and sIgE levels. Results: AR-related symptoms were most severe in Malays and least in Chinese (p < 0.01). Age (r = 0.516 to 0.673, p < 0.05) and duration of AR (r = 0.635 to 0.726, p < 0.01) correlated positively with severity domains (NSS, SSS, QLS, and TSS) in Chinese. Duration of concurrent allergies was highest in Malays (p < 0.05). Polysensitivity predicted increased sIgE levels in Malays (r = 0.464 to 0.551, p < 0.01) and Indians (r = 0.541 to 0.645, p < 0.05) but affected NSS, SSS, and TSS only in Indians (r = 0.216 to 0.376, p < 0.05). sIgE levels were lowest among Chinese but correlated strongly with NSS, OSS, SSS, and TSS (r = 0408 to 0.898, p < 0.05). Conclusion: Clinical parameters in AR may be influenced by race. Symptoms were most severe among Malays but did not correlate with other variables examined. Although Indian ethnicity did not impact disease severity, duration of concurrent allergies and mite-polysensitivity was associated with more severe disease. Age, duration of disease, and sIgE levels may be useful indicators of disease severity in Chinese. Wiley-Blackwell 2014 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/37503/1/SERUM.pdf Amini, Peyman and Abdullah, Maha and Lee, Sing Seng and Karunakaran, Thanusha and Norzhafarina Hani and Abu Bakar, Saraiza and Abdul Latiff, Amir Hamzah and Seow, Heng Fong and Yap, Yoke Yeow (2014) Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia. Internationa Forum on Allergy and Rhinology, 6 (6). pp. 624-630. ISSN 2042-6976; ESSN: 2042-6984 https://pubmed.ncbi.nlm.nih.gov/26919193/ 10.1002/alr.21442 |
| spellingShingle | Amini, Peyman Abdullah, Maha Lee, Sing Seng Karunakaran, Thanusha Norzhafarina Hani Abu Bakar, Saraiza Abdul Latiff, Amir Hamzah Seow, Heng Fong Yap, Yoke Yeow Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia |
| title | Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia |
| title_full | Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia |
| title_fullStr | Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia |
| title_full_unstemmed | Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia |
| title_short | Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia |
| title_sort | ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/37503/1/SERUM.pdf |
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