Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats
Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide...
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| Format: | Article |
| Language: | English |
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Elsevier
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37534/1/Evaluation%20of%20metabolic%20and%20immunological%20changes%20in%20streptozotocin.pdf |
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| author | Mojani, Mansooreh Sadat Sarmadi, Vahid Hosseinpour Vellasamy, Shalini Sandrasaigaran, Pratheep Rahmat, Asmah Loh, Su Peng Ramasamy, Rajesh |
| author_facet | Mojani, Mansooreh Sadat Sarmadi, Vahid Hosseinpour Vellasamy, Shalini Sandrasaigaran, Pratheep Rahmat, Asmah Loh, Su Peng Ramasamy, Rajesh |
| author_sort | Mojani, Mansooreh Sadat |
| collection | UPM |
| description | Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic rats as a model of type 2 diabetes. Male rats were induced diabetes using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg). Following 42 days, biochemical and immunological tests showed that diabetic rats had higher levels of blood glucose, WBC, certain abnormalities in lipid profile and insufficient mitogenic responses of lymphocytes (p < 0.05). However, the status of the total antioxidant, inflammatory biomarkers and other parameters of full blood count (except HCT) were not significantly altered. Phenotyping assay indicated insignificant lymphocyte subtype imbalances excluding a significant rise in the level of CD4+CD25+ marker (p < 0.05). This model of diabetic animals may represent some but not all symptoms of human type 2 diabetes. |
| first_indexed | 2024-03-06T08:38:38Z |
| format | Article |
| id | upm.eprints-37534 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:38:38Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-375342015-10-06T03:44:07Z http://psasir.upm.edu.my/id/eprint/37534/ Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats Mojani, Mansooreh Sadat Sarmadi, Vahid Hosseinpour Vellasamy, Shalini Sandrasaigaran, Pratheep Rahmat, Asmah Loh, Su Peng Ramasamy, Rajesh Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic rats as a model of type 2 diabetes. Male rats were induced diabetes using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg). Following 42 days, biochemical and immunological tests showed that diabetic rats had higher levels of blood glucose, WBC, certain abnormalities in lipid profile and insufficient mitogenic responses of lymphocytes (p < 0.05). However, the status of the total antioxidant, inflammatory biomarkers and other parameters of full blood count (except HCT) were not significantly altered. Phenotyping assay indicated insignificant lymphocyte subtype imbalances excluding a significant rise in the level of CD4+CD25+ marker (p < 0.05). This model of diabetic animals may represent some but not all symptoms of human type 2 diabetes. Elsevier 2014-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37534/1/Evaluation%20of%20metabolic%20and%20immunological%20changes%20in%20streptozotocin.pdf Mojani, Mansooreh Sadat and Sarmadi, Vahid Hosseinpour and Vellasamy, Shalini and Sandrasaigaran, Pratheep and Rahmat, Asmah and Loh, Su Peng and Ramasamy, Rajesh (2014) Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats. Cellular Immunology, 289 (1-2). pp. 145-149. ISSN 0008-8749; ESSN: 1090-2163 http://www.sciencedirect.com/science/article/pii/S0008874914000690 10.1016/j.cellimm.2014.04.004 |
| spellingShingle | Mojani, Mansooreh Sadat Sarmadi, Vahid Hosseinpour Vellasamy, Shalini Sandrasaigaran, Pratheep Rahmat, Asmah Loh, Su Peng Ramasamy, Rajesh Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats |
| title | Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats |
| title_full | Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats |
| title_fullStr | Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats |
| title_full_unstemmed | Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats |
| title_short | Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats |
| title_sort | evaluation of metabolic and immunological changes in streptozotocin nicotinamide induced diabetic rats |
| url | http://psasir.upm.edu.my/id/eprint/37534/1/Evaluation%20of%20metabolic%20and%20immunological%20changes%20in%20streptozotocin.pdf |
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