GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity
Cosmos caudatus, which is known as “Ulam Raja,” is an herbal plant used in Malaysia to enhance vitality. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 1...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Institute of Food Technologists
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37740/1/37740.pdf |
| _version_ | 1796973207939448832 |
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| author | Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Khatib, Alfi |
| author_facet | Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Khatib, Alfi |
| author_sort | Javadi, Neda |
| collection | UPM |
| description | Cosmos caudatus, which is known as “Ulam Raja,” is an herbal plant used in Malaysia to enhance vitality. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol (EtOH) were employed. Gas chromatography-mass spectrometry (GC-MS) and orthogonal partial least-squares (OPLS) analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained OPLS scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different ethanol concentrations. GC-MS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. In addition, catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified and indicate the potential α-glucosidase inhibitory activity of this herb. |
| first_indexed | 2024-03-06T08:39:15Z |
| format | Article |
| id | upm.eprints-37740 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:39:15Z |
| publishDate | 2014 |
| publisher | Institute of Food Technologists |
| record_format | dspace |
| spelling | upm.eprints-377402016-04-22T04:01:27Z http://psasir.upm.edu.my/id/eprint/37740/ GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Khatib, Alfi Cosmos caudatus, which is known as “Ulam Raja,” is an herbal plant used in Malaysia to enhance vitality. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol (EtOH) were employed. Gas chromatography-mass spectrometry (GC-MS) and orthogonal partial least-squares (OPLS) analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained OPLS scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different ethanol concentrations. GC-MS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. In addition, catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified and indicate the potential α-glucosidase inhibitory activity of this herb. Institute of Food Technologists 2014-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37740/1/37740.pdf Javadi, Neda and Abas, Faridah and Abdul Hamid, Azizah and Simoh, Sanimah and Shaari, Khozirah and Ismail, Intan Safinar and Mediani, Ahmed and Khatib, Alfi (2014) GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity. Journal of Food Science, 79 (6). C1130-C1136. ISSN 0022-1147; ESSN: 1750-3841 http://onlinelibrary.wiley.com/doi/10.1111/1750-3841.12491/abstract 10.1111/1750-3841.12491 |
| spellingShingle | Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Khatib, Alfi GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity |
| title | GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity |
| title_full | GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity |
| title_fullStr | GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity |
| title_full_unstemmed | GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity |
| title_short | GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity |
| title_sort | gc ms based metabolite profiling of cosmos caudatus leaves possessing alpha glucosidase inhibitory activity |
| url | http://psasir.upm.edu.my/id/eprint/37740/1/37740.pdf |
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