High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats
Insulin resistance is a growing worldwide syndrome that predispose human to a number of chronic diseases such as diabetes and cardiovascular diseases. Various studies have indicated that insulin action is highly influenced by diet compositions particularly dietary fat intake and proportion of n-3 an...
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| Format: | Article |
| Language: | English |
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Asian Network for Scientific Information
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37862/1/High-fat%20diets%20rich%20in%20n-3%20polyunsaturated%20fatty%20acids%20delay%20onset%20of%20insulin%20resistance%20in%20rats.pdf |
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| author | Tekeleselassie, A. W. Rajion, Mohamed Ali Goh, Yong Meng Moteshakeri, M. Farjam, Abdoreza Soleimani Ebrahimi, Mahdi |
| author_facet | Tekeleselassie, A. W. Rajion, Mohamed Ali Goh, Yong Meng Moteshakeri, M. Farjam, Abdoreza Soleimani Ebrahimi, Mahdi |
| author_sort | Tekeleselassie, A. W. |
| collection | UPM |
| description | Insulin resistance is a growing worldwide syndrome that predispose human to a number of chronic diseases such as diabetes and cardiovascular diseases. Various studies have indicated that insulin action is highly influenced by diet compositions particularly dietary fat intake and proportion of n-3 and n-6 Polyunsaturated Fatty Acids (PUFA). The current study was designed to assess the influence of High Fat Diet (HFD) with different n-6: n-3 Fatty Acid Ratios (FAR) on insulin sensitivity, plasma triacylglycerol (TAG) and lipoprotein profile. Forty male Sprague-Dawley rats were randomly allocated into four groups and received the isocaloric high fat diets enriched with either high n-6: n-3 fatty acid ratio (HFAR), medium n-6: n-3 fatty acid ratio (MFAR), low n-6: n-3 fatty acid ratio (LFAR) and compared with control rats fed standard chow (CTRL). The plasma insulin level of HFAR fed rats manifested significantly (P<0.05) higher concentration in most of the time points compared to the other groups. The corresponding insulin AUC (ng/L/120min) and insulin sensitivity index of HFAR fed rats appeared to be significantly higher (P<0.05) than CTRL (335.5±38.5), LFAR (273.7±37.6) and MFAR (265.9±21.7) groups. Blood lipid profile were found to be healthier in the LFAR and MFAR supplemented groups with significantly (P<0.05) lower total cholesterol and TAG levels. This study showed the possible protective effect against insulin resistance when low n-6: n-3 fatty acid ratio in high fat diets are applied in a rat model. |
| first_indexed | 2024-03-06T08:39:35Z |
| format | Article |
| id | upm.eprints-37862 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:39:35Z |
| publishDate | 2014 |
| publisher | Asian Network for Scientific Information |
| record_format | dspace |
| spelling | upm.eprints-378622015-12-08T01:20:20Z http://psasir.upm.edu.my/id/eprint/37862/ High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats Tekeleselassie, A. W. Rajion, Mohamed Ali Goh, Yong Meng Moteshakeri, M. Farjam, Abdoreza Soleimani Ebrahimi, Mahdi Insulin resistance is a growing worldwide syndrome that predispose human to a number of chronic diseases such as diabetes and cardiovascular diseases. Various studies have indicated that insulin action is highly influenced by diet compositions particularly dietary fat intake and proportion of n-3 and n-6 Polyunsaturated Fatty Acids (PUFA). The current study was designed to assess the influence of High Fat Diet (HFD) with different n-6: n-3 Fatty Acid Ratios (FAR) on insulin sensitivity, plasma triacylglycerol (TAG) and lipoprotein profile. Forty male Sprague-Dawley rats were randomly allocated into four groups and received the isocaloric high fat diets enriched with either high n-6: n-3 fatty acid ratio (HFAR), medium n-6: n-3 fatty acid ratio (MFAR), low n-6: n-3 fatty acid ratio (LFAR) and compared with control rats fed standard chow (CTRL). The plasma insulin level of HFAR fed rats manifested significantly (P<0.05) higher concentration in most of the time points compared to the other groups. The corresponding insulin AUC (ng/L/120min) and insulin sensitivity index of HFAR fed rats appeared to be significantly higher (P<0.05) than CTRL (335.5±38.5), LFAR (273.7±37.6) and MFAR (265.9±21.7) groups. Blood lipid profile were found to be healthier in the LFAR and MFAR supplemented groups with significantly (P<0.05) lower total cholesterol and TAG levels. This study showed the possible protective effect against insulin resistance when low n-6: n-3 fatty acid ratio in high fat diets are applied in a rat model. Asian Network for Scientific Information 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37862/1/High-fat%20diets%20rich%20in%20n-3%20polyunsaturated%20fatty%20acids%20delay%20onset%20of%20insulin%20resistance%20in%20rats.pdf Tekeleselassie, A. W. and Rajion, Mohamed Ali and Goh, Yong Meng and Moteshakeri, M. and Farjam, Abdoreza Soleimani and Ebrahimi, Mahdi (2014) High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats. Pakistan Journal of Nutrition, 13 (4). pp. 223-233. ISSN 1680-5194; ESSN: 1994-7984 http://scialert.net/abstract/?doi=pjn.2014.223.233 10.3923/pjn.2014.223.233 |
| spellingShingle | Tekeleselassie, A. W. Rajion, Mohamed Ali Goh, Yong Meng Moteshakeri, M. Farjam, Abdoreza Soleimani Ebrahimi, Mahdi High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats |
| title | High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats |
| title_full | High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats |
| title_fullStr | High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats |
| title_full_unstemmed | High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats |
| title_short | High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats |
| title_sort | high fat diets rich in n 3 polyunsaturated fatty acids delay onset of insulin resistance in rats |
| url | http://psasir.upm.edu.my/id/eprint/37862/1/High-fat%20diets%20rich%20in%20n-3%20polyunsaturated%20fatty%20acids%20delay%20onset%20of%20insulin%20resistance%20in%20rats.pdf |
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