Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers
Hyaluronatelyase produced by various microorganisms are capable of degrading hyaluronic acid in connective tissues and initiating the spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronatelyase-producing St...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Parasitology and Tropical Medicine
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/37899/1/Hyaluronatelyase%20production%20by%20Streptococcus%20pneumoniae%20isolated%20from%20patients%20and%20carriers.pdf |
| _version_ | 1825949121701216256 |
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| author | Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida Fatema @ Farida |
| author_facet | Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida Fatema @ Farida |
| author_sort | Ahmad Yusof @ Hanafi, Hanani |
| collection | UPM |
| description | Hyaluronatelyase produced by various microorganisms are capable of degrading hyaluronic acid in connective tissues and initiating the spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronatelyase-producing Streptococcus pneumoniae among invasive, non invasive and carriage isolates, and correlate it with the clinical sources, year of isolation, colonial morphology and their serotypes. A total of 100 isolates from various clinical samples were selected and screened for hyaluronatelyase production and presence of the encoding SpnHyl gene. All isolates possessed SpnHyl gene. Ninety-six isolates including 34 carriage isolates were positive for production of hyaluronatelyase. Four hyaluronatelyase-negative isolates were from blood (2 isolates) and sputum (2 isolates). No significant association was detected among hyaluronatelyase production and bacterial characteristics except for colonial morphology (p = 0.040). High percentages of hyaluronatelyase production in these isolates suggest their possible role as human pathogens. |
| first_indexed | 2024-03-06T08:39:42Z |
| format | Article |
| id | upm.eprints-37899 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:39:42Z |
| publishDate | 2015 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| record_format | dspace |
| spelling | upm.eprints-378992016-07-04T05:23:04Z http://psasir.upm.edu.my/id/eprint/37899/ Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida Fatema @ Farida Hyaluronatelyase produced by various microorganisms are capable of degrading hyaluronic acid in connective tissues and initiating the spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronatelyase-producing Streptococcus pneumoniae among invasive, non invasive and carriage isolates, and correlate it with the clinical sources, year of isolation, colonial morphology and their serotypes. A total of 100 isolates from various clinical samples were selected and screened for hyaluronatelyase production and presence of the encoding SpnHyl gene. All isolates possessed SpnHyl gene. Ninety-six isolates including 34 carriage isolates were positive for production of hyaluronatelyase. Four hyaluronatelyase-negative isolates were from blood (2 isolates) and sputum (2 isolates). No significant association was detected among hyaluronatelyase production and bacterial characteristics except for colonial morphology (p = 0.040). High percentages of hyaluronatelyase production in these isolates suggest their possible role as human pathogens. Malaysian Society of Parasitology and Tropical Medicine 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/37899/1/Hyaluronatelyase%20production%20by%20Streptococcus%20pneumoniae%20isolated%20from%20patients%20and%20carriers.pdf Ahmad Yusof @ Hanafi, Hanani and Mohd Desa, Mohd Nasir and Masri, Siti Norbaya and Osman, Malina and Jamal, Farida Fatema @ Farida (2015) Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers. Tropical Biomedicine, 32 (3). pp. 413-418. ISSN 0127-5720 http://www.msptm.org/journal35.html |
| spellingShingle | Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida Fatema @ Farida Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers |
| title | Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers |
| title_full | Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers |
| title_fullStr | Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers |
| title_full_unstemmed | Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers |
| title_short | Hyaluronatelyase production by Streptococcus pneumoniae isolated from patients and carriers |
| title_sort | hyaluronatelyase production by streptococcus pneumoniae isolated from patients and carriers |
| url | http://psasir.upm.edu.my/id/eprint/37899/1/Hyaluronatelyase%20production%20by%20Streptococcus%20pneumoniae%20isolated%20from%20patients%20and%20carriers.pdf |
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