A statistical study on the development of metronidazole-chitosan-alginate nanocomposite formulation using the full factorial design

A statistical study on the development of metronidazole-chitosan-alginate nanocomposite formulation using the full factorial design

The goal of this study was to develop and statistically optimize the metronidazole (MET), chitosan (CS) and alginate (Alg) nanoparticles (NP) nanocomposites (MET-CS-AlgNPs) using a (21 × 31 × 21) × 3 = 36 full factorial design (FFD) to investigate the effect of chitosan and alginate polymer concentr...

Full description

Bibliographic Details
Main Authors:	Sabbagh, Hazem Abdul Kader, Hussein-Al-Ali, Samer Hasan, Hussein, Mohd Zobir, Abudayeh, Zead, Ayoub, Rami, Abudoleh, Suha Mujahed
Format:	Article
Language:	English
Published:	MDPI 2020
Online Access:	http://psasir.upm.edu.my/id/eprint/38158/1/38158.pdf

Similar Items

Preparation and characterisation of ciprofloxacin‐loaded silver nanoparticles for drug delivery
by: Samer Hasan Hussein‐Al‐Ali, et al.
Published: (2022-05-01)

Graphene oxide‐ellagic acid nanocomposite as effective anticancer and antimicrobial agent
by: Samer Hasan Hussein‐Al‐Ali, et al.
Published: (2021-02-01)

The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities
by: El Zowalaty, Mohamed Ezzat, et al.
Published: (2015)

Preparation of chitosan nanoparticles as a drug delivery system for perindopril erbumine
by: Hussein-Al-Ali, Samer Hasan, et al.
Published: (2018)

Preparation and properties of poly(vinyl alcohol)/chitosan blend bio-nanocomposites reinforced by cellulose nanocrystals
by: Azizi, Susan, et al.
Published: (2014)

An evaluation of neurotoxic effect of metronidazole in rabbits
by: Wisam Hussein Al shibani, et al.
Published: (2011-12-01)

Green synthesis and characterization of silver/chitosan/polyethylene glycol nanocomposites without any reducing agent.
by: Ahmad @ Ayob, Mansor, et al.
Published: (2011)

In vivo evaluation of bioactivity of alginate/chitosan based osteoplastic nanocomposites loaded with inorganic nanoparticles
by: Oleksii Korenkov, et al.
Published: (2024-07-01)

The Effect of Chitosan/Alginate/Graphene Oxide Nanocomposites on Proliferation of Mouse Spermatogonial Stem Cells
by: Alaa Moeinzadeh, et al.
Published: (2023-11-01)

Arginine–chitosan- and arginine–polyethylene glycol-conjugated superparamagnetic nanoparticles: preparation, cytotoxicity and controlled-release
by: Hussein Al-Ali, Samer Hasan, et al.
Published: (2014)

Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system
by: Kura, Aminu Umar, et al.
Published: (2014)

Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System
by: Aminu Umar Kura, et al.
Published: (2014-01-01)

A β–Sitosterol Encapsulated Biocompatible Alginate/Chitosan Polymer Nanocomposite for the Treatment of Breast Cancer
by: Obaid Afzal, et al.
Published: (2022-08-01)

Nickel vanadate-polyaniline nanocomposite for electrochemical sensing of metronidazole in urine and milk
by: N.V. Sathya Jyothi, et al.
Published: (2024-06-01)

Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease
by: Qais Abualassal, et al.
Published: (2025-01-01)

Anticancer and antimicrobial potential of zinc/sodium alginate/polyethylene glycol/d-pinitol nanocomposites against osteosarcoma MG-63 cells
by: Lakshmanan Anandaraj, et al.
Published: (2023-12-01)

Sustained release formulation of an anti-tuberculosis drug based on para-amino salicylic acid-zinc layered hydroxide nanocomposite
by: Saifullah, Bullo, et al.
Published: (2013)

Gold Nanoparticles Loaded with Chitosan Encapsulate Donepezil as a Novel Nanocomposite for Alzheimer's Disease Therapy
by: Lina Mohammad Saleh Al-Sarayra, et al.
Published: (2024-04-01)

Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds
by: Weiyan Quan, et al.
Published: (2022-10-01)

Chitosan/Alginate nanocomposites containing magnetic nanoparticles and multi-wall carbon nanotubes for efficient iron sorption
by: Kawthar A. Omran, et al.
Published: (2024-01-01)

Review on nanocomposite materials from cellulose, chitosan, alginate, and lignin for removal and recovery of nutrients from wastewater
by: Aminat Mohammed Ahmed, et al.
Published: (2023-12-01)

Cellulose nanocrystals/ZnO as a bifunctional reinforcing nanocomposite for poly (vinyl alcohol)/chitosan blend films: fabrication, characterization and properties
by: Azizi, Susan, et al.
Published: (2014)

Chitosan-based agronanochemicals as a sustainable alternative in crop protection
by: Maluin, Farhatun Najat, et al.
Published: (2020)

Chitosan-Based Agronanochemicals as a Sustainable Alternative in Crop Protection
by: Farhatun Najat Maluin, et al.
Published: (2020-04-01)

Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
by: Hussein-Al-Ali, Samer Hasan, et al.
Published: (2014)

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite.
by: Barahuie, Farahnaz, et al.
Published: (2013)

Antimicrobial activity of hippurate nanocomposite and its cytotoxicity effect in combination with cytarabine against HL-60
by: Hussein Al Ali, Samer Hassan, et al.
Published: (2013)

Hippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines.
by: Hussein Al Ali, Samer Hassan, et al.
Published: (2013)

Equilibrium and Kinetic Study of Anionic and Cationic Pollutants Remediation by Limestone–Chitosan–Alginate Nanocomposite from Aqueous Solution
by: Inas A. Ahmed, et al.
Published: (2021-04-01)

Perindopril erbumine-layered double hydroxide nanocomposite as a controlled release formulation of an anti hypertensive drug
by: Hussein, Mohd Zobir, et al.
Published: (2012)

Modification of Cellulose Products by the Use of Chitosan and Chitosan-Alginate Nano-Particles
by: Brzoza-Malczewska Kinga, et al.
Published: (2016-03-01)

Fabrication of pH-Responsive Chitosan/Polyvinylpyrrolidone Hydrogels for Controlled Release of Metronidazole and Antibacterial Properties
by: Zerihun Feyissa, et al.
Published: (2023-01-01)

Evaluation of the cytotoxic effect of ellagic acid nanocomposite in lung cancer A549 cell line and RAW 264.9 cells
by: Hussein Al-Ali, Samer Hasan Ahmad, et al.
Published: (2017)

Enhanced drug delivery and wound healing potential of berberine-loaded chitosan–alginate nanocomposite gel: characterization and in vivo assessment
by: Md Habban Akhter, et al.
Published: (2023-12-01)

The in vitro therapeutic activity of ellagic acid-alginate-silver nanopeprintss on breast cancer cells (MCF-7) and normal fibroblast cells (3T3)
by: Hussein-Al-Ali, Samer Hasan, et al.
Published: (2016)

Synthesis and properties of zinc-aluminium-acetylsalicylate-nanocomposite
by: Yahaya, Asmah, et al.
Published: (2005)

Adsorption characteristics of metronidazole on CoZr-LDH and its GO nanocomposite: Experimental and theoretical study
by: Edris Jamshidi, et al.
Published: (2025-02-01)

Monitoring plant responses in field-grown peanuts exposed to exogenously applied chitosan under full and limited irrigation levels
by: Kassem A. S. Mohammed, et al.
Published: (2024-03-01)

Adsorption of heavy metal ions use chitosan/graphene nanocomposites: A review study
by: Chou-Yi Hsu, et al.
Published: (2024-01-01)

Controlled Release of Curcumin by Graphene Oxide/Chitosan/Sodium Alginate Hydrogel Multilayer Nanocomposites and Evaluate its Synergistic Antibacterial Activity
by: Shirin Soltani, et al.
Published: (2023-09-01)