Curcumin combination chemotherapy: the implication and efficacy in cancer
Many chemotherapeutic drugs have been used for the treatment of cancer, for instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, the effectiveness of chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, and undesirable side effe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/38330/1/38330.pdf |
| _version_ | 1796973324885032960 |
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| author | Tan, Bee Ling Mohd Esa, Norhaizan |
| author_facet | Tan, Bee Ling Mohd Esa, Norhaizan |
| author_sort | Tan, Bee Ling |
| collection | UPM |
| description | Many chemotherapeutic drugs have been used for the treatment of cancer, for instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, the effectiveness of chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, and undesirable side effects. The combination of therapies with natural compounds is likely to increase the effectiveness of drug treatment as well as reduce the adverse outcomes. Curcumin, a polyphenolic isolated from Curcuma longa, belongs to the rhizome of Zingiberaceae plants. Studies from in vitro and in vivo revealed that curcumin exerts many pharmacological activities with less toxic effects. The biological mechanisms underlying the anticancer activity of co-treatment curcumin and chemotherapy are complex and worth to discuss further. Therefore, this review aimed to address the molecular mechanisms of combined curcumin and chemotherapy in the treatment of cancer. The anticancer activity of combined nanoformulation of curcumin and chemotherapy was also discussed in this study. Taken together, a better understanding of the implication and underlying mechanisms of action of combined curcumin and chemotherapy may provide a useful approach to combat cancer diseases. |
| first_indexed | 2024-03-06T08:40:59Z |
| format | Article |
| id | upm.eprints-38330 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:40:59Z |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-383302020-05-04T16:18:17Z http://psasir.upm.edu.my/id/eprint/38330/ Curcumin combination chemotherapy: the implication and efficacy in cancer Tan, Bee Ling Mohd Esa, Norhaizan Many chemotherapeutic drugs have been used for the treatment of cancer, for instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, the effectiveness of chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, and undesirable side effects. The combination of therapies with natural compounds is likely to increase the effectiveness of drug treatment as well as reduce the adverse outcomes. Curcumin, a polyphenolic isolated from Curcuma longa, belongs to the rhizome of Zingiberaceae plants. Studies from in vitro and in vivo revealed that curcumin exerts many pharmacological activities with less toxic effects. The biological mechanisms underlying the anticancer activity of co-treatment curcumin and chemotherapy are complex and worth to discuss further. Therefore, this review aimed to address the molecular mechanisms of combined curcumin and chemotherapy in the treatment of cancer. The anticancer activity of combined nanoformulation of curcumin and chemotherapy was also discussed in this study. Taken together, a better understanding of the implication and underlying mechanisms of action of combined curcumin and chemotherapy may provide a useful approach to combat cancer diseases. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38330/1/38330.pdf Tan, Bee Ling and Mohd Esa, Norhaizan (2019) Curcumin combination chemotherapy: the implication and efficacy in cancer. Molecules, 24 (14). art. no. 2527. pp. 1-21. ISSN 1420-3049 https://www.mdpi.com/1420-3049/24/14/2527 10.3390/molecules24142527 |
| spellingShingle | Tan, Bee Ling Mohd Esa, Norhaizan Curcumin combination chemotherapy: the implication and efficacy in cancer |
| title | Curcumin combination chemotherapy: the implication and efficacy in cancer |
| title_full | Curcumin combination chemotherapy: the implication and efficacy in cancer |
| title_fullStr | Curcumin combination chemotherapy: the implication and efficacy in cancer |
| title_full_unstemmed | Curcumin combination chemotherapy: the implication and efficacy in cancer |
| title_short | Curcumin combination chemotherapy: the implication and efficacy in cancer |
| title_sort | curcumin combination chemotherapy the implication and efficacy in cancer |
| url | http://psasir.upm.edu.my/id/eprint/38330/1/38330.pdf |
| work_keys_str_mv | AT tanbeeling curcumincombinationchemotherapytheimplicationandefficacyincancer AT mohdesanorhaizan curcumincombinationchemotherapytheimplicationandefficacyincancer |