Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/38331/1/38331.pdf |
| _version_ | 1796973325086359552 |
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| author | Paulraj, Felicia Simone Abas, Faridah Lajis, Nordin Othman, Iekhsan Naidu, Rakesh |
| author_facet | Paulraj, Felicia Simone Abas, Faridah Lajis, Nordin Othman, Iekhsan Naidu, Rakesh |
| author_sort | Paulraj, Felicia Simone |
| collection | UPM |
| description | While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown improved cytotoxicity over curcumin. Investigations of diarylpentanoids have demonstrated that these compounds exert anti-cancer effects through several signalling pathways that are associated with cancer. This review focuses on selected diarylpentanoids and highlights molecular targets that modulate key pathways involved in cancer such as NF-κB, MAPK/ERK, and STAT signalling. Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models. |
| first_indexed | 2024-03-06T08:40:59Z |
| format | Article |
| id | upm.eprints-38331 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:40:59Z |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-383312020-05-04T16:18:22Z http://psasir.upm.edu.my/id/eprint/38331/ Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer Paulraj, Felicia Simone Abas, Faridah Lajis, Nordin Othman, Iekhsan Naidu, Rakesh While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown improved cytotoxicity over curcumin. Investigations of diarylpentanoids have demonstrated that these compounds exert anti-cancer effects through several signalling pathways that are associated with cancer. This review focuses on selected diarylpentanoids and highlights molecular targets that modulate key pathways involved in cancer such as NF-κB, MAPK/ERK, and STAT signalling. Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models. MDPI 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/38331/1/38331.pdf Paulraj, Felicia Simone and Abas, Faridah and Lajis, Nordin and Othman, Iekhsan and Naidu, Rakesh (2019) Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer. Biomolecules, 9 (7). art. no. 270. pp. 1-14. ISSN 2218-273X https://www.mdpi.com/2218-273X/9/7/270 10.3390/biom9070270 |
| spellingShingle | Paulraj, Felicia Simone Abas, Faridah Lajis, Nordin Othman, Iekhsan Naidu, Rakesh Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer |
| title | Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer |
| title_full | Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer |
| title_fullStr | Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer |
| title_full_unstemmed | Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer |
| title_short | Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer |
| title_sort | molecular pathways modulated by curcumin analogue diarylpentanoids in cancer |
| url | http://psasir.upm.edu.my/id/eprint/38331/1/38331.pdf |
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