Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits
Atherosclerosis is a condition of the arterial wall injury which is prominently driven by inflammatory responses. The objective of this investigation is to evaluate the anti-inflammatory and/or antiproliferative effect of zerumbone (ZER) against early-developed atherosclerotic lesion in the aorta. N...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/39239/1/39239.pdf |
| _version_ | 1796973500879077376 |
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| author | Othman, Hemn Hassan Hamzah, Hazilawati Rahman, Heshu Sulaiman Abu Bakar @ Zakaria, Md Zuki Mohamed Mustapha, Noordin |
| author_facet | Othman, Hemn Hassan Hamzah, Hazilawati Rahman, Heshu Sulaiman Abu Bakar @ Zakaria, Md Zuki Mohamed Mustapha, Noordin |
| author_sort | Othman, Hemn Hassan |
| collection | UPM |
| description | Atherosclerosis is a condition of the arterial wall injury which is prominently driven by inflammatory responses. The objective of this investigation is to evaluate the anti-inflammatory and/or antiproliferative effect of zerumbone (ZER) against early-developed atherosclerotic lesion in the aorta. New Zealand White male rabbits used in the present study were randomly assigned into seven experimental groups, viz; the control (CN) which was fed a standard rabbit pellet diet, a 1% cholesterol diet (CP), 0.4% ZER (Z+CP) for two weeks before day 0 as preventive measure and thereafter with the course of cholesterol-rich diet, 0.8% ZER (Z1+CP), 1.0% ZER (Z2+CP), 20 mg/kg Simvastatin (S+CP) and 0.8% ZER plus 20 mg/kg Simvastatin (S+Z+CP). Experimental groups of Z1+CP to S+Z+CP acted to represent the therapeutic measure of ZER against earlydeveloped atherosclerosis. Tissue samples were collected from the thoracic aorta and aortic arch at 14 weeks post-feeding for morphological studies. The aortic morphology revealed that while endothelial damage and
atheromas plague development progressed in the CP group, those receiving ZER has milder lesions. The effect of ZER was found to be in a dose-dependent manner. Our data indicate that dietary intake of ZER significantly averts and decreases early plague formation and development via inhibition of smooth muscle cells proliferation and inflammatory response. |
| first_indexed | 2024-03-06T08:43:35Z |
| format | Conference or Workshop Item |
| id | upm.eprints-39239 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:43:35Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | upm.eprints-392392017-01-09T09:20:32Z http://psasir.upm.edu.my/id/eprint/39239/ Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits Othman, Hemn Hassan Hamzah, Hazilawati Rahman, Heshu Sulaiman Abu Bakar @ Zakaria, Md Zuki Mohamed Mustapha, Noordin Atherosclerosis is a condition of the arterial wall injury which is prominently driven by inflammatory responses. The objective of this investigation is to evaluate the anti-inflammatory and/or antiproliferative effect of zerumbone (ZER) against early-developed atherosclerotic lesion in the aorta. New Zealand White male rabbits used in the present study were randomly assigned into seven experimental groups, viz; the control (CN) which was fed a standard rabbit pellet diet, a 1% cholesterol diet (CP), 0.4% ZER (Z+CP) for two weeks before day 0 as preventive measure and thereafter with the course of cholesterol-rich diet, 0.8% ZER (Z1+CP), 1.0% ZER (Z2+CP), 20 mg/kg Simvastatin (S+CP) and 0.8% ZER plus 20 mg/kg Simvastatin (S+Z+CP). Experimental groups of Z1+CP to S+Z+CP acted to represent the therapeutic measure of ZER against earlydeveloped atherosclerosis. Tissue samples were collected from the thoracic aorta and aortic arch at 14 weeks post-feeding for morphological studies. The aortic morphology revealed that while endothelial damage and atheromas plague development progressed in the CP group, those receiving ZER has milder lesions. The effect of ZER was found to be in a dose-dependent manner. Our data indicate that dietary intake of ZER significantly averts and decreases early plague formation and development via inhibition of smooth muscle cells proliferation and inflammatory response. 2012 Conference or Workshop Item NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/39239/1/39239.pdf Othman, Hemn Hassan and Hamzah, Hazilawati and Rahman, Heshu Sulaiman and Abu Bakar @ Zakaria, Md Zuki and Mohamed Mustapha, Noordin (2012) Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits. In: International Conference on One Health and 24th VAM Congress 2012, 21-23 Sept. 2012, Marriott Putrajaya. (pp. 389-391). |
| spellingShingle | Othman, Hemn Hassan Hamzah, Hazilawati Rahman, Heshu Sulaiman Abu Bakar @ Zakaria, Md Zuki Mohamed Mustapha, Noordin Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits |
| title | Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits |
| title_full | Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits |
| title_fullStr | Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits |
| title_full_unstemmed | Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits |
| title_short | Attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits |
| title_sort | attenuation of atherosclerosis by zerumbone in hypercholesterolaemic rabbits |
| url | http://psasir.upm.edu.my/id/eprint/39239/1/39239.pdf |
| work_keys_str_mv | AT othmanhemnhassan attenuationofatherosclerosisbyzerumboneinhypercholesterolaemicrabbits AT hamzahhazilawati attenuationofatherosclerosisbyzerumboneinhypercholesterolaemicrabbits AT rahmanheshusulaiman attenuationofatherosclerosisbyzerumboneinhypercholesterolaemicrabbits AT abubakarzakariamdzuki attenuationofatherosclerosisbyzerumboneinhypercholesterolaemicrabbits AT mohamedmustaphanoordin attenuationofatherosclerosisbyzerumboneinhypercholesterolaemicrabbits |