Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP)
Objectives: To characterize mechanisms of macrolide resistance among Streptococcus pneumoniae from 10 Asian countries during 1998-2001. Methods: Phenotypic and genotypic characterization of the isolates and their resistance mechanisms. Results: Of 555 isolates studied, 216 (38.9%) were susceptible,...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
British Society for Antimicrobial Chemotherapy
2004
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/40241/1/Macrolide%20resistance%20and%20genotypic%20characterization%20of%20Streptococcus%20pneumoniae%20in%20Asian%20countries%29.pdf |
| _version_ | 1825949563895152640 |
|---|---|
| author | Song, Jae Hoon Chang, Hyun Ha Suh, Ji Yoeun Ko, Kwan Soo Jung, Sook In Oh, Won Sup Peck, Kyong Ran Lee, Nam Yong Yang, Yonghong Chongthaleong, Anan Aswapokee, Nalinee Chiu, Cheng Hsu Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Kumararasinghe, Gamini Jamal, Farida Kamarulzaman, Adeeba Parasakthi, Navaratnam Van, Pham Hung So, Thomas Man Kit Ng, Tak Keung |
| author_facet | Song, Jae Hoon Chang, Hyun Ha Suh, Ji Yoeun Ko, Kwan Soo Jung, Sook In Oh, Won Sup Peck, Kyong Ran Lee, Nam Yong Yang, Yonghong Chongthaleong, Anan Aswapokee, Nalinee Chiu, Cheng Hsu Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Kumararasinghe, Gamini Jamal, Farida Kamarulzaman, Adeeba Parasakthi, Navaratnam Van, Pham Hung So, Thomas Man Kit Ng, Tak Keung |
| author_sort | Song, Jae Hoon |
| collection | UPM |
| description | Objectives: To characterize mechanisms of macrolide resistance among Streptococcus pneumoniae from 10 Asian countries during 1998-2001. Methods: Phenotypic and genotypic characterization of the isolates and their resistance mechanisms. Results: Of 555 isolates studied, 216 (38.9%) were susceptible, 10 (1.8%) were intermediate and 329 (59.3%) were resistant to erythromycin. Vietnam had the highest prevalence of erythromycin resistance (88.3%), followed by Taiwan (87.2%), Korea (85.1%), Hong Kong (76.5%) and China (75.6%). Ribosomal methylation encoded by erm(B) was the most common mechanism of erythromycin resistance in China, Taiwan, Sri Lanka and Korea. In Hong Kong, Singapore, Thailand and Malaysia, efflux encoded by mef(A) was the more common in erythromycin-resistant isolates. In most Asian countries except Hong Kong, Malaysia and Singapore, erm(B) was found in >50% of pneumococcal isolates either alone or in combination with mef(A). The level of erythromycin resistance among pneumococcal isolates in most Asian countries except Thailand and India was very high with MIC90s of >128 mg/L. Molecular epidemiological studies suggest the horizontal transfer of the erm(B) gene and clonal dissemination of resistant strains in the Asian region. Conclusion: Data confirm that macrolide resistance in pneumococci is a serious problem in many Asian countries. |
| first_indexed | 2024-03-06T08:46:30Z |
| format | Article |
| id | upm.eprints-40241 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:46:30Z |
| publishDate | 2004 |
| publisher | British Society for Antimicrobial Chemotherapy |
| record_format | dspace |
| spelling | upm.eprints-402412015-09-14T08:50:39Z http://psasir.upm.edu.my/id/eprint/40241/ Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP) Song, Jae Hoon Chang, Hyun Ha Suh, Ji Yoeun Ko, Kwan Soo Jung, Sook In Oh, Won Sup Peck, Kyong Ran Lee, Nam Yong Yang, Yonghong Chongthaleong, Anan Aswapokee, Nalinee Chiu, Cheng Hsu Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Kumararasinghe, Gamini Jamal, Farida Kamarulzaman, Adeeba Parasakthi, Navaratnam Van, Pham Hung So, Thomas Man Kit Ng, Tak Keung Objectives: To characterize mechanisms of macrolide resistance among Streptococcus pneumoniae from 10 Asian countries during 1998-2001. Methods: Phenotypic and genotypic characterization of the isolates and their resistance mechanisms. Results: Of 555 isolates studied, 216 (38.9%) were susceptible, 10 (1.8%) were intermediate and 329 (59.3%) were resistant to erythromycin. Vietnam had the highest prevalence of erythromycin resistance (88.3%), followed by Taiwan (87.2%), Korea (85.1%), Hong Kong (76.5%) and China (75.6%). Ribosomal methylation encoded by erm(B) was the most common mechanism of erythromycin resistance in China, Taiwan, Sri Lanka and Korea. In Hong Kong, Singapore, Thailand and Malaysia, efflux encoded by mef(A) was the more common in erythromycin-resistant isolates. In most Asian countries except Hong Kong, Malaysia and Singapore, erm(B) was found in >50% of pneumococcal isolates either alone or in combination with mef(A). The level of erythromycin resistance among pneumococcal isolates in most Asian countries except Thailand and India was very high with MIC90s of >128 mg/L. Molecular epidemiological studies suggest the horizontal transfer of the erm(B) gene and clonal dissemination of resistant strains in the Asian region. Conclusion: Data confirm that macrolide resistance in pneumococci is a serious problem in many Asian countries. British Society for Antimicrobial Chemotherapy 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40241/1/Macrolide%20resistance%20and%20genotypic%20characterization%20of%20Streptococcus%20pneumoniae%20in%20Asian%20countries%29.pdf Song, Jae Hoon and Chang, Hyun Ha and Suh, Ji Yoeun and Ko, Kwan Soo and Jung, Sook In and Oh, Won Sup and Peck, Kyong Ran and Lee, Nam Yong and Yang, Yonghong and Chongthaleong, Anan and Aswapokee, Nalinee and Chiu, Cheng Hsu and Lalitha, Mukkai Kesavan and Perera, Jennifer and Yee, Ti Teow and Kumararasinghe, Gamini and Jamal, Farida and Kamarulzaman, Adeeba and Parasakthi, Navaratnam and Van, Pham Hung and So, Thomas Man Kit and Ng, Tak Keung (2004) Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP). Journal of Antimicrobial Chemotherapy, 53 (3). pp. 457-463. ISSN 0305-7453; ESSN: 1460-2091 http://jac.oxfordjournals.org/content/53/3/457.abstract 10.1093/jac/dkh118 |
| spellingShingle | Song, Jae Hoon Chang, Hyun Ha Suh, Ji Yoeun Ko, Kwan Soo Jung, Sook In Oh, Won Sup Peck, Kyong Ran Lee, Nam Yong Yang, Yonghong Chongthaleong, Anan Aswapokee, Nalinee Chiu, Cheng Hsu Lalitha, Mukkai Kesavan Perera, Jennifer Yee, Ti Teow Kumararasinghe, Gamini Jamal, Farida Kamarulzaman, Adeeba Parasakthi, Navaratnam Van, Pham Hung So, Thomas Man Kit Ng, Tak Keung Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP) |
| title | Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP) |
| title_full | Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP) |
| title_fullStr | Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP) |
| title_full_unstemmed | Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP) |
| title_short | Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP) |
| title_sort | macrolide resistance and genotypic characterization of streptococcus pneumoniae in asian countries a study of the asian network for surveillance of resistant pathogens ansorp |
| url | http://psasir.upm.edu.my/id/eprint/40241/1/Macrolide%20resistance%20and%20genotypic%20characterization%20of%20Streptococcus%20pneumoniae%20in%20Asian%20countries%29.pdf |
| work_keys_str_mv | AT songjaehoon macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT changhyunha macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT suhjiyoeun macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT kokwansoo macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT jungsookin macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT ohwonsup macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT peckkyongran macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT leenamyong macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT yangyonghong macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT chongthaleonganan macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT aswapokeenalinee macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT chiuchenghsu macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT lalithamukkaikesavan macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT pererajennifer macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT yeetiteow macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT kumararasinghegamini macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT jamalfarida macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT kamarulzamanadeeba macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT parasakthinavaratnam macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT vanphamhung macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT sothomasmankit macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp AT ngtakkeung macrolideresistanceandgenotypiccharacterizationofstreptococcuspneumoniaeinasiancountriesastudyoftheasiannetworkforsurveillanceofresistantpathogensansorp |