Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed
In this study, the vasodilatory actions of nine edible tropical plant extracts were investigated. Ipomoea batatas (sweet potato leaf), Piper betle (betel leaf), Anacardium occidentale (cashew leaf), Gynandropsis gynandra (maman leaf), Carica papaya (papaya leaf), and Mentha arvensis (mint leaf) extr...
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| Format: | Article |
| Language: | English |
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Elsevier
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40319/1/Vasorelaxation%20induced%20by%20common%20edible%20tropical%20plant%20extracts%20in%20isolated%20rat%20aorta%20and%20mesenteric%20vascular%20bed.pdf |
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| author | Henry Ginjom, Irine Runnie Salleh, Mohd Nizar Mohamed, Suhaila Head, Richard J. Abeywardena, Mahinda Y. |
| author_facet | Henry Ginjom, Irine Runnie Salleh, Mohd Nizar Mohamed, Suhaila Head, Richard J. Abeywardena, Mahinda Y. |
| author_sort | Henry Ginjom, Irine Runnie |
| collection | UPM |
| description | In this study, the vasodilatory actions of nine edible tropical plant extracts were investigated. Ipomoea batatas (sweet potato leaf), Piper betle (betel leaf), Anacardium occidentale (cashew leaf), Gynandropsis gynandra (maman leaf), Carica papaya (papaya leaf), and Mentha arvensis (mint leaf) extracts exhibited more than 50% relaxing effect on aortic ring preparations, while Piper betle and Cymbopogon citratus (lemongrass stalk) showed comparable vasorelaxation on isolated perfused mesenteric artery preparation. The vascular effect on the aortic ring preparations were mainly endothelium-dependent, and mediated by nitric oxide (NO) as supported by the inhibition of action in the presence of Nω-nitro-l-arginine (NOLA), an nitric oxide synthase (NOS) inhibitor, or by the removal of endothelium. In contrast, vasodilatory actions in resistance vessels (perfused mesenteric vascular beds) appear to involve several biochemical mediators, including NO, prostanoids, and endothelium-dependent hyperpolarizing factors (EDHFs). Total phenolic contents and antioxidant capacities varied among different extracts and found to be independent of vascular relaxation effects. This study demonstrates that many edible plants common in Asian diets to possess potential health benefits, affording protection at the vascular endothelium level. |
| first_indexed | 2024-03-06T08:46:43Z |
| format | Article |
| id | upm.eprints-40319 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:46:43Z |
| publishDate | 2004 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-403192015-09-17T01:11:34Z http://psasir.upm.edu.my/id/eprint/40319/ Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed Henry Ginjom, Irine Runnie Salleh, Mohd Nizar Mohamed, Suhaila Head, Richard J. Abeywardena, Mahinda Y. In this study, the vasodilatory actions of nine edible tropical plant extracts were investigated. Ipomoea batatas (sweet potato leaf), Piper betle (betel leaf), Anacardium occidentale (cashew leaf), Gynandropsis gynandra (maman leaf), Carica papaya (papaya leaf), and Mentha arvensis (mint leaf) extracts exhibited more than 50% relaxing effect on aortic ring preparations, while Piper betle and Cymbopogon citratus (lemongrass stalk) showed comparable vasorelaxation on isolated perfused mesenteric artery preparation. The vascular effect on the aortic ring preparations were mainly endothelium-dependent, and mediated by nitric oxide (NO) as supported by the inhibition of action in the presence of Nω-nitro-l-arginine (NOLA), an nitric oxide synthase (NOS) inhibitor, or by the removal of endothelium. In contrast, vasodilatory actions in resistance vessels (perfused mesenteric vascular beds) appear to involve several biochemical mediators, including NO, prostanoids, and endothelium-dependent hyperpolarizing factors (EDHFs). Total phenolic contents and antioxidant capacities varied among different extracts and found to be independent of vascular relaxation effects. This study demonstrates that many edible plants common in Asian diets to possess potential health benefits, affording protection at the vascular endothelium level. Elsevier 2004-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40319/1/Vasorelaxation%20induced%20by%20common%20edible%20tropical%20plant%20extracts%20in%20isolated%20rat%20aorta%20and%20mesenteric%20vascular%20bed.pdf Henry Ginjom, Irine Runnie and Salleh, Mohd Nizar and Mohamed, Suhaila and Head, Richard J. and Abeywardena, Mahinda Y. (2004) Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed. Journal of Ethnopharmacology, 92 (2-3). pp. 311-316. ISSN 0378-8741; ESSN: 1872-7573 http://www.sciencedirect.com/science/article/pii/S037887410400128X 10.1016/j.jep.2004.03.019 |
| spellingShingle | Henry Ginjom, Irine Runnie Salleh, Mohd Nizar Mohamed, Suhaila Head, Richard J. Abeywardena, Mahinda Y. Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed |
| title | Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed |
| title_full | Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed |
| title_fullStr | Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed |
| title_full_unstemmed | Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed |
| title_short | Vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed |
| title_sort | vasorelaxation induced by common edible tropical plant extracts in isolated rat aorta and mesenteric vascular bed |
| url | http://psasir.upm.edu.my/id/eprint/40319/1/Vasorelaxation%20induced%20by%20common%20edible%20tropical%20plant%20extracts%20in%20isolated%20rat%20aorta%20and%20mesenteric%20vascular%20bed.pdf |
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