Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats
Background: This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague–Dawley rats were randomly allotted in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40422/1/1471-2202-13-109.pdf |
| _version_ | 1825949598416371712 |
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| author | Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Othman, Fauziah Farjam, Abdoreza Soleimani Tan, Ai Li Ebrahimi, Mahdi |
| author_facet | Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Othman, Fauziah Farjam, Abdoreza Soleimani Tan, Ai Li Ebrahimi, Mahdi |
| author_sort | Hajjar, Toktam |
| collection | UPM |
| description | Background: This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague–Dawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10 weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPARα and PPARγ genes were determined using real-time PCR. Results: Decreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPARα and PPARγ gene expression. The animals with the lowest dietary n-6: n-3 PUFA ratio presented the highest spatial learning improvement and PPAR gene expression. Conclusion: It can be concluded that modulation of n-6: n-3 PUFA ratios in the diet may lead to increased hippocampal PPAR gene expression and consequently improved spatial learning and memory in rats. |
| first_indexed | 2024-03-06T08:47:01Z |
| format | Article |
| id | upm.eprints-40422 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:47:01Z |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | upm.eprints-404222015-09-18T02:19:12Z http://psasir.upm.edu.my/id/eprint/40422/ Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Othman, Fauziah Farjam, Abdoreza Soleimani Tan, Ai Li Ebrahimi, Mahdi Background: This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome- proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague–Dawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10 weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPARα and PPARγ genes were determined using real-time PCR. Results: Decreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPARα and PPARγ gene expression. The animals with the lowest dietary n-6: n-3 PUFA ratio presented the highest spatial learning improvement and PPAR gene expression. Conclusion: It can be concluded that modulation of n-6: n-3 PUFA ratios in the diet may lead to increased hippocampal PPAR gene expression and consequently improved spatial learning and memory in rats. BioMed Central 2012-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40422/1/1471-2202-13-109.pdf Hajjar, Toktam and Goh, Yong Meng and Rajion, Mohamed Ali and Vidyadaran, Sharmili and Othman, Fauziah and Farjam, Abdoreza Soleimani and Tan, Ai Li and Ebrahimi, Mahdi (2012) Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats. BMC Neuroscience, 13. art. no. 109. pp. 1-7. ISSN 1471-2202 http://www.biomedcentral.com/1471-2202/13/109/abstract 10.1186/1471-2202-13-109 |
| spellingShingle | Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Othman, Fauziah Farjam, Abdoreza Soleimani Tan, Ai Li Ebrahimi, Mahdi Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats |
| title | Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats |
| title_full | Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats |
| title_fullStr | Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats |
| title_full_unstemmed | Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats |
| title_short | Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats |
| title_sort | omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal peroxisome proliferator activated receptors pparα and pparγ gene expression in rats |
| url | http://psasir.upm.edu.my/id/eprint/40422/1/1471-2202-13-109.pdf |
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