A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients
This prospective 6-week study examined the differences in dosage and steady state plasma concentrations of sertraline in Chinese versus Caucasian depressed patients. Two groups of Chinese patients from different geographical sites and a group of Caucasian patients were evaluated with clinical measur...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Lippincott Williams & Wilkins
2006
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40426/1/A%20comparative%20study%20of%20sertraline%20dosages%2C%20plasma%20concentrations%2C%20efficacy%20and%20adverse%20reactions%20in%20Chinese%20versus%20Caucasian%20patients.pdf |
| _version_ | 1796973738561896448 |
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| author | Ng, Chee Hong Norman, Trevor R. Naing, Khin Ohnmar Schweitzer, Isaac Kong, Brian Wai Ho Fan, Agnes Klimidis, Steven |
| author_facet | Ng, Chee Hong Norman, Trevor R. Naing, Khin Ohnmar Schweitzer, Isaac Kong, Brian Wai Ho Fan, Agnes Klimidis, Steven |
| author_sort | Ng, Chee Hong |
| collection | UPM |
| description | This prospective 6-week study examined the differences in dosage and steady state plasma concentrations of sertraline in Chinese versus Caucasian depressed patients. Two groups of Chinese patients from different geographical sites and a group of Caucasian patients were evaluated with clinical measures during an initial dose of 50 mg/day, with subsequent doses adjusted clinically. The results of 17 Australian Chinese (ACHI), 13 Malaysian Chinese (MCHI) and 15 Australian Caucasians (AC) were analysed. Despite controlling for weight, the AC subjects received a significantly higher dose than both the ACHI (P=0.002) and the MCHI groups (P=0.012). However, the mean sertraline concentration to dose ratios at weeks 1 and 6 were not significantly different between the three groups. Sertraline was effective and well tolerated in both ethnic groups with few adverse events. Although there was a lack of difference between groups in the pharmacokinetic results, Chinese depressed patients appeared to require lower dosages with consequently lower plasma concentrations of sertraline compared to Caucasian patients to achieve clinical efficacy. Further studies of the dosages, kinetics and adverse effects of selective serotonin reuptake inhibitors linked with genotyping are necessary. |
| first_indexed | 2024-03-06T08:47:02Z |
| format | Article |
| id | upm.eprints-40426 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:47:02Z |
| publishDate | 2006 |
| publisher | Lippincott Williams & Wilkins |
| record_format | dspace |
| spelling | upm.eprints-404262015-09-18T02:29:21Z http://psasir.upm.edu.my/id/eprint/40426/ A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients Ng, Chee Hong Norman, Trevor R. Naing, Khin Ohnmar Schweitzer, Isaac Kong, Brian Wai Ho Fan, Agnes Klimidis, Steven This prospective 6-week study examined the differences in dosage and steady state plasma concentrations of sertraline in Chinese versus Caucasian depressed patients. Two groups of Chinese patients from different geographical sites and a group of Caucasian patients were evaluated with clinical measures during an initial dose of 50 mg/day, with subsequent doses adjusted clinically. The results of 17 Australian Chinese (ACHI), 13 Malaysian Chinese (MCHI) and 15 Australian Caucasians (AC) were analysed. Despite controlling for weight, the AC subjects received a significantly higher dose than both the ACHI (P=0.002) and the MCHI groups (P=0.012). However, the mean sertraline concentration to dose ratios at weeks 1 and 6 were not significantly different between the three groups. Sertraline was effective and well tolerated in both ethnic groups with few adverse events. Although there was a lack of difference between groups in the pharmacokinetic results, Chinese depressed patients appeared to require lower dosages with consequently lower plasma concentrations of sertraline compared to Caucasian patients to achieve clinical efficacy. Further studies of the dosages, kinetics and adverse effects of selective serotonin reuptake inhibitors linked with genotyping are necessary. Lippincott Williams & Wilkins 2006-03 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40426/1/A%20comparative%20study%20of%20sertraline%20dosages%2C%20plasma%20concentrations%2C%20efficacy%20and%20adverse%20reactions%20in%20Chinese%20versus%20Caucasian%20patients.pdf Ng, Chee Hong and Norman, Trevor R. and Naing, Khin Ohnmar and Schweitzer, Isaac and Kong, Brian Wai Ho and Fan, Agnes and Klimidis, Steven (2006) A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients. International Clinical Psychopharmacology, 21 (2). pp. 87-92. ISSN 0268-1315; ESSN: 1473-5857 http://journals.lww.com/intclinpsychopharm/pages/articleviewer.aspx?year=2006&issue=03000&article=00003&type=abstract 10.1097/01.yic.0000188214.46667.3f |
| spellingShingle | Ng, Chee Hong Norman, Trevor R. Naing, Khin Ohnmar Schweitzer, Isaac Kong, Brian Wai Ho Fan, Agnes Klimidis, Steven A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients |
| title | A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients |
| title_full | A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients |
| title_fullStr | A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients |
| title_full_unstemmed | A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients |
| title_short | A comparative study of sertraline dosages, plasma concentrations, efficacy and adverse reactions in Chinese versus Caucasian patients |
| title_sort | comparative study of sertraline dosages plasma concentrations efficacy and adverse reactions in chinese versus caucasian patients |
| url | http://psasir.upm.edu.my/id/eprint/40426/1/A%20comparative%20study%20of%20sertraline%20dosages%2C%20plasma%20concentrations%2C%20efficacy%20and%20adverse%20reactions%20in%20Chinese%20versus%20Caucasian%20patients.pdf |
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