Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages
The current study was designed to evaluate whether compounds isolated from local medicinal plants in Malaysia suppressed nitric oxide (NO) production in inflammation. The murine monocytic macrophage (RAW 264.7) cell line was used as a target cell and activated by interferon-γ. (IFN-γ.) and lipopolys...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2006
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/40439/1/Effect%20of%20compounds%20isolated%20from%20natural%20products%20on%20IFN-%CE%B3LPS%20%20induced%20nitric%20oxide%20production%20in%20RAW%20264.7%20macrophages.pdf |
| _version_ | 1825949601737211904 |
|---|---|
| author | Ahmad, Syahida Ahmad Israf, Daud Lajis, Nordin Shaari, Khozirah Mohamad, Habsah Karim, Jasril Permana, Dharma I., Norhadiani |
| author_facet | Ahmad, Syahida Ahmad Israf, Daud Lajis, Nordin Shaari, Khozirah Mohamad, Habsah Karim, Jasril Permana, Dharma I., Norhadiani |
| author_sort | Ahmad, Syahida |
| collection | UPM |
| description | The current study was designed to evaluate whether compounds isolated from local medicinal plants in Malaysia suppressed nitric oxide (NO) production in inflammation. The murine monocytic macrophage (RAW 264.7) cell line was used as a target cell and activated by interferon-γ. (IFN-γ.) and lipopolysaccharide (LPS). Our current study has identified four phytochemicals, namely atrovirinone, cardamonin, flavokawin B, and zerumbone, that inhibit pathological NO generation. These compounds are candidates for further bioassay studies to determine their suitability as drug leads. |
| first_indexed | 2024-03-06T08:47:04Z |
| format | Article |
| id | upm.eprints-40439 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:47:04Z |
| publishDate | 2006 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | upm.eprints-404392015-09-18T03:23:54Z http://psasir.upm.edu.my/id/eprint/40439/ Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages Ahmad, Syahida Ahmad Israf, Daud Lajis, Nordin Shaari, Khozirah Mohamad, Habsah Karim, Jasril Permana, Dharma I., Norhadiani The current study was designed to evaluate whether compounds isolated from local medicinal plants in Malaysia suppressed nitric oxide (NO) production in inflammation. The murine monocytic macrophage (RAW 264.7) cell line was used as a target cell and activated by interferon-γ. (IFN-γ.) and lipopolysaccharide (LPS). Our current study has identified four phytochemicals, namely atrovirinone, cardamonin, flavokawin B, and zerumbone, that inhibit pathological NO generation. These compounds are candidates for further bioassay studies to determine their suitability as drug leads. Taylor & Francis 2006 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40439/1/Effect%20of%20compounds%20isolated%20from%20natural%20products%20on%20IFN-%CE%B3LPS%20%20induced%20nitric%20oxide%20production%20in%20RAW%20264.7%20macrophages.pdf Ahmad, Syahida and Ahmad Israf, Daud and Lajis, Nordin and Shaari, Khozirah and Mohamad, Habsah and Karim, Jasril and Permana, Dharma and I., Norhadiani (2006) Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages. Pharmaceutical Biology, 44 (1). pp. 50-59. ISSN 1388-0209; ESSN: 1744-5116 http://www.tandfonline.com/doi/abs/10.1080/13880200500530765 10.1080/13880200500530765 |
| spellingShingle | Ahmad, Syahida Ahmad Israf, Daud Lajis, Nordin Shaari, Khozirah Mohamad, Habsah Karim, Jasril Permana, Dharma I., Norhadiani Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages |
| title | Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages |
| title_full | Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages |
| title_fullStr | Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages |
| title_full_unstemmed | Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages |
| title_short | Effect of compounds isolated from natural products on IFN-γ/LPS- induced nitric oxide production in RAW 264.7 macrophages |
| title_sort | effect of compounds isolated from natural products on ifn γ lps induced nitric oxide production in raw 264 7 macrophages |
| url | http://psasir.upm.edu.my/id/eprint/40439/1/Effect%20of%20compounds%20isolated%20from%20natural%20products%20on%20IFN-%CE%B3LPS%20%20induced%20nitric%20oxide%20production%20in%20RAW%20264.7%20macrophages.pdf |
| work_keys_str_mv | AT ahmadsyahida effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages AT ahmadisrafdaud effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages AT lajisnordin effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages AT shaarikhozirah effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages AT mohamadhabsah effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages AT karimjasril effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages AT permanadharma effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages AT inorhadiani effectofcompoundsisolatedfromnaturalproductsonifnglpsinducednitricoxideproductioninraw2647macrophages |