Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
In the course of our search for novel platelet-activating factor (PAF) antagonists from medicinal plants, the methanol extract of the leaves of Ardisia elliptica Thunb. was investigated for its inhibitory effects on PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The methanol extr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/40443/1/Bioassay-guided%20isolation%20of%20a%20potent%20platelet-activating%20factor%20antagonist%20alkenylresorcinol%20from%20Ardisia%20elliptica.pdf |
| _version_ | 1825949602512109568 |
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| author | Jalil, Juriyati Jantan, Ibrahim Shaari, Khozirah Abdul Rafi, Iftikhar Ahmad |
| author_facet | Jalil, Juriyati Jantan, Ibrahim Shaari, Khozirah Abdul Rafi, Iftikhar Ahmad |
| author_sort | Jalil, Juriyati |
| collection | UPM |
| description | In the course of our search for novel platelet-activating factor (PAF) antagonists from medicinal plants, the methanol extract of the leaves of Ardisia elliptica Thunb. was investigated for its inhibitory effects on PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The methanol extract showed inhibitory activity of 53.9% and its ethyl acetate, n-butanol, and methanol fractions exhibited 48.6%, 39.0%, and 22.0% inhibition, respectively. Bioassay-guided fractionation of the ethyl acetate fraction led to the isolation of a new alkenylresorcinol, 5-(Z-heptadec-4′-enyl)resorcinol, together with 5-pentadecylresorcinol. The alkenylresorcinol showed a strong inhibition with an IC50 value of 7.1 µM. The structures of the compounds were elucidated by spectroscopic techniques. |
| first_indexed | 2024-03-06T08:47:05Z |
| format | Article |
| id | upm.eprints-40443 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:47:05Z |
| publishDate | 2004 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | upm.eprints-404432015-09-18T03:44:36Z http://psasir.upm.edu.my/id/eprint/40443/ Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica Jalil, Juriyati Jantan, Ibrahim Shaari, Khozirah Abdul Rafi, Iftikhar Ahmad In the course of our search for novel platelet-activating factor (PAF) antagonists from medicinal plants, the methanol extract of the leaves of Ardisia elliptica Thunb. was investigated for its inhibitory effects on PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The methanol extract showed inhibitory activity of 53.9% and its ethyl acetate, n-butanol, and methanol fractions exhibited 48.6%, 39.0%, and 22.0% inhibition, respectively. Bioassay-guided fractionation of the ethyl acetate fraction led to the isolation of a new alkenylresorcinol, 5-(Z-heptadec-4′-enyl)resorcinol, together with 5-pentadecylresorcinol. The alkenylresorcinol showed a strong inhibition with an IC50 value of 7.1 µM. The structures of the compounds were elucidated by spectroscopic techniques. Taylor & Francis 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/40443/1/Bioassay-guided%20isolation%20of%20a%20potent%20platelet-activating%20factor%20antagonist%20alkenylresorcinol%20from%20Ardisia%20elliptica.pdf Jalil, Juriyati and Jantan, Ibrahim and Shaari, Khozirah and Abdul Rafi, Iftikhar Ahmad (2004) Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica. Pharmaceutical Biology, 42 (6). pp. 457-461. ISSN 1388-0209; ESSN: 1744-5116 http://www.tandfonline.com/doi/abs/10.1080/13880200490886157 10.1080/13880200490886157 |
| spellingShingle | Jalil, Juriyati Jantan, Ibrahim Shaari, Khozirah Abdul Rafi, Iftikhar Ahmad Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica |
| title | Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica |
| title_full | Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica |
| title_fullStr | Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica |
| title_full_unstemmed | Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica |
| title_short | Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica |
| title_sort | bioassay guided isolation of a potent platelet activating factor antagonist alkenylresorcinol from ardisia elliptica |
| url | http://psasir.upm.edu.my/id/eprint/40443/1/Bioassay-guided%20isolation%20of%20a%20potent%20platelet-activating%20factor%20antagonist%20alkenylresorcinol%20from%20Ardisia%20elliptica.pdf |
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