Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia
We reported a young patient with myelodysplastic syndrome (MDS) with eosinophilia, in which her chromosomal analysis revealed the presence of trisomy X and a marker chromosome at chromosome 11. The technique used to detect the chromosomal abnormalities is a multicoloured –fluorescent in situ hybridi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2012
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/41205/1/Trisomy%20X%20and%20Myelodysplastic%20Syndrome%20%28MDS%29%20with%20eosinophilia.pdf |
| _version_ | 1825949741436895232 |
|---|---|
| author | Mohd Tohit, Eusni Rahayu Leong, Chooi Fun Shuib, Salwati |
| author_facet | Mohd Tohit, Eusni Rahayu Leong, Chooi Fun Shuib, Salwati |
| author_sort | Mohd Tohit, Eusni Rahayu |
| collection | UPM |
| description | We reported a young patient with myelodysplastic syndrome (MDS) with eosinophilia, in which her chromosomal analysis revealed the presence of trisomy X and a marker chromosome at chromosome 11. The technique used to detect the chromosomal abnormalities is a multicoloured –fluorescent in situ hybridization technique (M-FISH). Our observation suggested that these underlying chromosomal abnormalities were probably responsible for her development of MDS with eosinophilia. Myelodysplastic syndrome (MDS) is a condition whereby there is ineffective production of haematopoietic stem cells and poor quality of cells produced. The cause can either be a primary bone marrow problem, de novo or therapy related. Most MDS cases are secondary rather than primary. Many chromosomal abnormalities have been found in cases of myelodysplastic syndrome. We described a case of MDS with eosinophilia in association with presence of trisomy X and a marker chromosome in chromosome 11. |
| first_indexed | 2024-03-06T08:49:14Z |
| format | Article |
| id | upm.eprints-41205 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:49:14Z |
| publishDate | 2012 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-412052015-12-07T01:55:58Z http://psasir.upm.edu.my/id/eprint/41205/ Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia Mohd Tohit, Eusni Rahayu Leong, Chooi Fun Shuib, Salwati We reported a young patient with myelodysplastic syndrome (MDS) with eosinophilia, in which her chromosomal analysis revealed the presence of trisomy X and a marker chromosome at chromosome 11. The technique used to detect the chromosomal abnormalities is a multicoloured –fluorescent in situ hybridization technique (M-FISH). Our observation suggested that these underlying chromosomal abnormalities were probably responsible for her development of MDS with eosinophilia. Myelodysplastic syndrome (MDS) is a condition whereby there is ineffective production of haematopoietic stem cells and poor quality of cells produced. The cause can either be a primary bone marrow problem, de novo or therapy related. Most MDS cases are secondary rather than primary. Many chromosomal abnormalities have been found in cases of myelodysplastic syndrome. We described a case of MDS with eosinophilia in association with presence of trisomy X and a marker chromosome in chromosome 11. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2012-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/41205/1/Trisomy%20X%20and%20Myelodysplastic%20Syndrome%20%28MDS%29%20with%20eosinophilia.pdf Mohd Tohit, Eusni Rahayu and Leong, Chooi Fun and Shuib, Salwati (2012) Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia. Malaysian Journal of Medicine and Health Sciences, 8 (2). pp. 65-67. ISSN 1675-8544 http://www.medic.upm.edu.my/dokumen/FKUSK1_MJMHS_2012V08N2_CS01.pdf |
| spellingShingle | Mohd Tohit, Eusni Rahayu Leong, Chooi Fun Shuib, Salwati Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia |
| title | Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia |
| title_full | Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia |
| title_fullStr | Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia |
| title_full_unstemmed | Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia |
| title_short | Trisomy X and myelodysplastic syndrome (MDS) with eosinophilia |
| title_sort | trisomy x and myelodysplastic syndrome mds with eosinophilia |
| url | http://psasir.upm.edu.my/id/eprint/41205/1/Trisomy%20X%20and%20Myelodysplastic%20Syndrome%20%28MDS%29%20with%20eosinophilia.pdf |
| work_keys_str_mv | AT mohdtohiteusnirahayu trisomyxandmyelodysplasticsyndromemdswitheosinophilia AT leongchooifun trisomyxandmyelodysplasticsyndromemdswitheosinophilia AT shuibsalwati trisomyxandmyelodysplasticsyndromemdswitheosinophilia |