Chemical constituents and biological activities of Callicarpa maingayi leaves
Plants have an extensive diversity of natural phytochemicals that are used as a source of medicine. In this study the methanolic leaf extract of Callicarpa maingayi together with its increasing polarity soluble fractions hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc), n-butanol (n-BuOH),...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43262/1/Chemical%20constituents%20and%20biological%20activities%20of%20Callicarpa%20maingayi%20leaves.pdf |
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| author | Ado, Muhammad Abubakar Abas, Faridah Leong, Sze Wei Shaari, Khozirah Ismail, Intan Safinar Mohd Ghazali, Hasanah Lajis, Md. Nordin |
| author_facet | Ado, Muhammad Abubakar Abas, Faridah Leong, Sze Wei Shaari, Khozirah Ismail, Intan Safinar Mohd Ghazali, Hasanah Lajis, Md. Nordin |
| author_sort | Ado, Muhammad Abubakar |
| collection | UPM |
| description | Plants have an extensive diversity of natural phytochemicals that are used as a source of medicine. In this study the methanolic leaf extract of Callicarpa maingayi together with its increasing polarity soluble fractions hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc), n-butanol (n-BuOH), and aqueous (Aq) fractions were examined on antioxidant, acetylcholinesterase (AChE), tyrosinase, and α-glucosidase inhibitory activities. Liquid chromatography-diode array detection-electrospray ionization-tandem mass spectrometry (LC-DAD-ESIMS/MS) was used to analyze the most bioactive fractions (EtOAc and n-BuOH). A total of 20 compounds were tentatively identified in these two active fractions. Forsythoside B, acteoside, isoacteoside, isocampneoside II, apigenin 7-O-rutinoside and kaempferol 3-sulfate-7-arabinopyranoside were identified by comparing with the reference standard. Other compounds including cistanoside F, apigenin 6-C-glucoside-8-C-glucoside, β-OH-forsythoside B, campneoside II, rhamnazin 3-O-rutinoside, campneoside I, eukovoside, acacetin diglucoronide, acacetin 7-O-glucuronide, β-OH-poliumoside, poliumoside as well as 3 isomers of 2′-acetylacteoside were tentatively identified based on their UV spectra and MS/MS data. All of the compounds were reported from this species for the first time. The results have indicated the chemical constituents of C. maingayi that contributed to the biological activity and thus, it may have potential application toward the development of nutraceutical and medicinal preparations. |
| first_indexed | 2024-03-06T08:55:08Z |
| format | Article |
| id | upm.eprints-43262 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:55:08Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-432622016-05-18T04:36:14Z http://psasir.upm.edu.my/id/eprint/43262/ Chemical constituents and biological activities of Callicarpa maingayi leaves Ado, Muhammad Abubakar Abas, Faridah Leong, Sze Wei Shaari, Khozirah Ismail, Intan Safinar Mohd Ghazali, Hasanah Lajis, Md. Nordin Plants have an extensive diversity of natural phytochemicals that are used as a source of medicine. In this study the methanolic leaf extract of Callicarpa maingayi together with its increasing polarity soluble fractions hexane (Hex), dichloromethane (DCM), ethyl acetate (EtOAc), n-butanol (n-BuOH), and aqueous (Aq) fractions were examined on antioxidant, acetylcholinesterase (AChE), tyrosinase, and α-glucosidase inhibitory activities. Liquid chromatography-diode array detection-electrospray ionization-tandem mass spectrometry (LC-DAD-ESIMS/MS) was used to analyze the most bioactive fractions (EtOAc and n-BuOH). A total of 20 compounds were tentatively identified in these two active fractions. Forsythoside B, acteoside, isoacteoside, isocampneoside II, apigenin 7-O-rutinoside and kaempferol 3-sulfate-7-arabinopyranoside were identified by comparing with the reference standard. Other compounds including cistanoside F, apigenin 6-C-glucoside-8-C-glucoside, β-OH-forsythoside B, campneoside II, rhamnazin 3-O-rutinoside, campneoside I, eukovoside, acacetin diglucoronide, acacetin 7-O-glucuronide, β-OH-poliumoside, poliumoside as well as 3 isomers of 2′-acetylacteoside were tentatively identified based on their UV spectra and MS/MS data. All of the compounds were reported from this species for the first time. The results have indicated the chemical constituents of C. maingayi that contributed to the biological activity and thus, it may have potential application toward the development of nutraceutical and medicinal preparations. Elsevier 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43262/1/Chemical%20constituents%20and%20biological%20activities%20of%20Callicarpa%20maingayi%20leaves.pdf Ado, Muhammad Abubakar and Abas, Faridah and Leong, Sze Wei and Shaari, Khozirah and Ismail, Intan Safinar and Mohd Ghazali, Hasanah and Lajis, Md. Nordin (2016) Chemical constituents and biological activities of Callicarpa maingayi leaves. South African Journal of Botany, 104. pp. 98-104. ISSN 0254-6299; ESSN: 1727-9321 http://www.sciencedirect.com/science/article/pii/S0254629916000223 10.1016/j.sajb.2015.11.010 |
| spellingShingle | Ado, Muhammad Abubakar Abas, Faridah Leong, Sze Wei Shaari, Khozirah Ismail, Intan Safinar Mohd Ghazali, Hasanah Lajis, Md. Nordin Chemical constituents and biological activities of Callicarpa maingayi leaves |
| title | Chemical constituents and biological activities of Callicarpa maingayi leaves |
| title_full | Chemical constituents and biological activities of Callicarpa maingayi leaves |
| title_fullStr | Chemical constituents and biological activities of Callicarpa maingayi leaves |
| title_full_unstemmed | Chemical constituents and biological activities of Callicarpa maingayi leaves |
| title_short | Chemical constituents and biological activities of Callicarpa maingayi leaves |
| title_sort | chemical constituents and biological activities of callicarpa maingayi leaves |
| url | http://psasir.upm.edu.my/id/eprint/43262/1/Chemical%20constituents%20and%20biological%20activities%20of%20Callicarpa%20maingayi%20leaves.pdf |
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