Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice
The objective of this study is to evaluate the effect of allicin (10mg/kg body weight, orally) in an experimental murine model of UC by administering 2.5% dextran sodium sulfate (DSS) in drinking water to BALB/c mice. DSS-induced mice presented reduced body weight, which was improved by allicin admi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43689/1/Allicin%20Alleviates%20Dextran%20Sodium.pdf |
| _version_ | 1796974393572720640 |
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| author | Pandurangan, Ashok Kumar Ismail, Salmiah Saadatdoust, Zeinab Mohd Esa, Norhaizan |
| author_facet | Pandurangan, Ashok Kumar Ismail, Salmiah Saadatdoust, Zeinab Mohd Esa, Norhaizan |
| author_sort | Pandurangan, Ashok Kumar |
| collection | UPM |
| description | The objective of this study is to evaluate the effect of allicin (10mg/kg body weight, orally) in an experimental murine model of UC by administering 2.5% dextran sodium sulfate (DSS) in drinking water to BALB/c mice. DSS-induced mice presented reduced body weight, which was improved by allicin administration. We noted increases in CD68 expression, myeloperoxidase (MPO) activities, and Malonaldehyde (MDA) and mRNA levels of proinflammatory cytokines, such as tumor necrosis factor- (TNF-) |
| first_indexed | 2024-03-06T08:56:25Z |
| format | Article |
| id | upm.eprints-43689 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:56:25Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | upm.eprints-436892016-08-08T09:13:47Z http://psasir.upm.edu.my/id/eprint/43689/ Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice Pandurangan, Ashok Kumar Ismail, Salmiah Saadatdoust, Zeinab Mohd Esa, Norhaizan The objective of this study is to evaluate the effect of allicin (10mg/kg body weight, orally) in an experimental murine model of UC by administering 2.5% dextran sodium sulfate (DSS) in drinking water to BALB/c mice. DSS-induced mice presented reduced body weight, which was improved by allicin administration. We noted increases in CD68 expression, myeloperoxidase (MPO) activities, and Malonaldehyde (MDA) and mRNA levels of proinflammatory cytokines, such as tumor necrosis factor- (TNF-) Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/43689/1/Allicin%20Alleviates%20Dextran%20Sodium.pdf Pandurangan, Ashok Kumar and Ismail, Salmiah and Saadatdoust, Zeinab and Mohd Esa, Norhaizan (2015) Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice. Oxidative Medicine and Cellular Longevity, 2015. art. no. 60520. pp. 1-13. ISSN 1942-0900; ESSN: 1942-0994 http://www.hindawi.com/journals/omcl/2015/605208/ 10.1155/2015/605208 |
| spellingShingle | Pandurangan, Ashok Kumar Ismail, Salmiah Saadatdoust, Zeinab Mohd Esa, Norhaizan Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice |
| title | Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice |
| title_full | Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice |
| title_fullStr | Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice |
| title_full_unstemmed | Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice |
| title_short | Allicin alleviates Dextran Sodium Sulfate (DSS)-induced ulcerative colitis in BALB/c mice |
| title_sort | allicin alleviates dextran sodium sulfate dss induced ulcerative colitis in balb c mice |
| url | http://psasir.upm.edu.my/id/eprint/43689/1/Allicin%20Alleviates%20Dextran%20Sodium.pdf |
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