Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships
Extensive chromatographic isolation and purification of the extracts of the stem bark of Calophyllum inophyllum and Calophyllum soulattri have resulted in 11 xanthones. C. inophyllum gave inophinnin (1), inophinone (2), pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7) and 4-hydroxyxa...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/43982/1/Calophyllum%20inophyllum%20and%20Calophyllum%20soulattri%20source%20of%20anti-proliferative%20xanthones%20and%20their%20structure-activity%20relationships.pdf |
| _version_ | 1796974451728842752 |
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| author | Mah, Siau Hui Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah |
| author_facet | Mah, Siau Hui Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah |
| author_sort | Mah, Siau Hui |
| collection | UPM |
| description | Extensive chromatographic isolation and purification of the extracts of the stem bark of Calophyllum inophyllum and Calophyllum soulattri have resulted in 11 xanthones. C. inophyllum gave inophinnin (1), inophinone (2), pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7) and 4-hydroxyxanthone (8), while C. soulattri afforded soulattrin (3), phylattrin (4), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D NMR, GC-MS, IR and UV. Cytotoxicity screening (MTT assay) carried out in vitro on all the xanthones using five human cancer cell lines indicated good activities for some of these xanthones. The structure-activity relationship study revealed that the inhibitory activities exhibited by these xanthone derivatives to be closely related to the existence and nature of the pyrano and the prenyl substituent groups on their skeleton. |
| first_indexed | 2024-03-06T08:57:16Z |
| format | Article |
| id | upm.eprints-43982 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:57:16Z |
| publishDate | 2015 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | upm.eprints-439822022-02-12T02:39:07Z http://psasir.upm.edu.my/id/eprint/43982/ Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships Mah, Siau Hui Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah Extensive chromatographic isolation and purification of the extracts of the stem bark of Calophyllum inophyllum and Calophyllum soulattri have resulted in 11 xanthones. C. inophyllum gave inophinnin (1), inophinone (2), pyranojacareubin (5), rheediaxanthone A (6), macluraxanthone (7) and 4-hydroxyxanthone (8), while C. soulattri afforded soulattrin (3), phylattrin (4), caloxanthone C (9), brasixanthone B (10) and trapezifolixanthone (11). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D NMR, GC-MS, IR and UV. Cytotoxicity screening (MTT assay) carried out in vitro on all the xanthones using five human cancer cell lines indicated good activities for some of these xanthones. The structure-activity relationship study revealed that the inhibitory activities exhibited by these xanthone derivatives to be closely related to the existence and nature of the pyrano and the prenyl substituent groups on their skeleton. Taylor & Francis 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/43982/1/Calophyllum%20inophyllum%20and%20Calophyllum%20soulattri%20source%20of%20anti-proliferative%20xanthones%20and%20their%20structure-activity%20relationships.pdf Mah, Siau Hui and Cheng, Gwendoline Lian Ee and Soek, Sin Teh and Sukari, Mohd Aspollah (2015) Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships. Natural Product Research, 29 (1). pp. 98-101. ISSN 1478-6419; ESSN:1478-6427 https://www.tandfonline.com/doi/abs/10.1080/14786419.2014.959949 10.1080/14786419.2014.959949 |
| spellingShingle | Mah, Siau Hui Cheng, Gwendoline Lian Ee Soek, Sin Teh Sukari, Mohd Aspollah Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships |
| title | Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships |
| title_full | Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships |
| title_fullStr | Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships |
| title_full_unstemmed | Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships |
| title_short | Calophyllum inophyllum and Calophyllum soulattri source of anti-proliferative xanthones and their structure-activity relationships |
| title_sort | calophyllum inophyllum and calophyllum soulattri source of anti proliferative xanthones and their structure activity relationships |
| url | http://psasir.upm.edu.my/id/eprint/43982/1/Calophyllum%20inophyllum%20and%20Calophyllum%20soulattri%20source%20of%20anti-proliferative%20xanthones%20and%20their%20structure-activity%20relationships.pdf |
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