Causes of genome instability: the effect of low dose chemical exposures in modern society
Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thu...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/44007/1/Causes%20of%20genome%20instability%20the%20effect%20of%20low%20dose%20chemical%20exposures%20in%20modern%20society.pdf |
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| author | Langie, Sabine A. S. Koppen, Gudrun Desaulniers, Daniel Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Azqueta, Amaya Bisson, William H. Brown, Dustin Brunborg, Gunnar Charles, Amelia K. Chen, Tao Colacci, Annamaria Darroudi, Firouz Forte, Stefano Gonzalez, Laetitia A.Hamid, Roslida |
| author_facet | Langie, Sabine A. S. Koppen, Gudrun Desaulniers, Daniel Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Azqueta, Amaya Bisson, William H. Brown, Dustin Brunborg, Gunnar Charles, Amelia K. Chen, Tao Colacci, Annamaria Darroudi, Firouz Forte, Stefano Gonzalez, Laetitia A.Hamid, Roslida |
| author_sort | Langie, Sabine A. S. |
| collection | UPM |
| description | Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced tendency for the genome to acquire mutations; ranging from changes to the nucleotide sequence to chromosomal gain, rearrangements or loss. This review raises the hypothesis that in addition to known human carcinogens, exposure to low dose of other chemicals present in our modern society could contribute to carcinogenesis by indirectly affecting genome stability. The selected chemicals with their mechanisms of action proposed to indirectly contribute to genome instability are: heavy metals (DNA repair, epigenetic modification, DNA damage signaling, telomere length), acrylamide (DNA repair, chromosome segregation), bisphenol A (epigenetic modification, DNA damage signaling, mitochondrial function, chromosome segregation), benomyl (chromosome segregation), quinones (epigenetic modification) and nano-sized particles (epigenetic pathways, mitochondrial function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make scientists aware of the increasing need to unravel the underlying mechanisms via which chemicals at low doses can induce genome instability and thus promote carcinogenesis. |
| first_indexed | 2024-03-06T08:57:19Z |
| format | Article |
| id | upm.eprints-44007 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:57:19Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | upm.eprints-440072022-02-08T02:17:04Z http://psasir.upm.edu.my/id/eprint/44007/ Causes of genome instability: the effect of low dose chemical exposures in modern society Langie, Sabine A. S. Koppen, Gudrun Desaulniers, Daniel Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Azqueta, Amaya Bisson, William H. Brown, Dustin Brunborg, Gunnar Charles, Amelia K. Chen, Tao Colacci, Annamaria Darroudi, Firouz Forte, Stefano Gonzalez, Laetitia A.Hamid, Roslida Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced tendency for the genome to acquire mutations; ranging from changes to the nucleotide sequence to chromosomal gain, rearrangements or loss. This review raises the hypothesis that in addition to known human carcinogens, exposure to low dose of other chemicals present in our modern society could contribute to carcinogenesis by indirectly affecting genome stability. The selected chemicals with their mechanisms of action proposed to indirectly contribute to genome instability are: heavy metals (DNA repair, epigenetic modification, DNA damage signaling, telomere length), acrylamide (DNA repair, chromosome segregation), bisphenol A (epigenetic modification, DNA damage signaling, mitochondrial function, chromosome segregation), benomyl (chromosome segregation), quinones (epigenetic modification) and nano-sized particles (epigenetic pathways, mitochondrial function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make scientists aware of the increasing need to unravel the underlying mechanisms via which chemicals at low doses can induce genome instability and thus promote carcinogenesis. Oxford University Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/44007/1/Causes%20of%20genome%20instability%20the%20effect%20of%20low%20dose%20chemical%20exposures%20in%20modern%20society.pdf Langie, Sabine A. S. and Koppen, Gudrun and Desaulniers, Daniel and Al-Mulla, Fahd and Al-Temaimi, Rabeah and Amedei, Amedeo and Azqueta, Amaya and Bisson, William H. and Brown, Dustin and Brunborg, Gunnar and Charles, Amelia K. and Chen, Tao and Colacci, Annamaria and Darroudi, Firouz and Forte, Stefano and Gonzalez, Laetitia and A.Hamid, Roslida (2015) Causes of genome instability: the effect of low dose chemical exposures in modern society. Carcinogenesis, 36 (suppl. 1). pp. 61-88. ISSN 0143-3334; ESSN: 1460-2180 https://academic.oup.com/carcin/article/36/Suppl_1/S61/311923 10.1093/carcin/bgv031 |
| spellingShingle | Langie, Sabine A. S. Koppen, Gudrun Desaulniers, Daniel Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Azqueta, Amaya Bisson, William H. Brown, Dustin Brunborg, Gunnar Charles, Amelia K. Chen, Tao Colacci, Annamaria Darroudi, Firouz Forte, Stefano Gonzalez, Laetitia A.Hamid, Roslida Causes of genome instability: the effect of low dose chemical exposures in modern society |
| title | Causes of genome instability: the effect of low dose chemical exposures in modern society |
| title_full | Causes of genome instability: the effect of low dose chemical exposures in modern society |
| title_fullStr | Causes of genome instability: the effect of low dose chemical exposures in modern society |
| title_full_unstemmed | Causes of genome instability: the effect of low dose chemical exposures in modern society |
| title_short | Causes of genome instability: the effect of low dose chemical exposures in modern society |
| title_sort | causes of genome instability the effect of low dose chemical exposures in modern society |
| url | http://psasir.upm.edu.my/id/eprint/44007/1/Causes%20of%20genome%20instability%20the%20effect%20of%20low%20dose%20chemical%20exposures%20in%20modern%20society.pdf |
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