Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates
This is a cross-sectional study conducted among paddy farmers to characterize potential risk factors that influence levels of DNA damage from exposure to mixtures of organophosphates. Comet assay was used to determine the level of DNA damage by measuring the comet tail length from the exfoliated buc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Inc
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/44043/1/Characterization%20of%20risk%20factors%20for%20DNA%20damage%20among%20paddy%20farm%20worker%20exposed%20to%20mixtures%20of%20organophosphates.pdf |
| _version_ | 1825929482313138176 |
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| author | How, Vivien Hashim, Zailina Ismail, Patimah Omar, Dzolkhifli Md Said, Salmiah Mohd Tamrin, Shamsul Bahri |
| author_facet | How, Vivien Hashim, Zailina Ismail, Patimah Omar, Dzolkhifli Md Said, Salmiah Mohd Tamrin, Shamsul Bahri |
| author_sort | How, Vivien |
| collection | UPM |
| description | This is a cross-sectional study conducted among paddy farmers to characterize potential risk factors that influence levels of DNA damage from exposure to mixtures of organophosphates. Comet assay was used to determine the level of DNA damage by measuring the comet tail length from the exfoliated buccal mucosa. The result suggests that farmers who chronically exposure to a mixture of organophosphates has at least 2-fold significant increase of DNA damage as compared with control group. Factor analysis and linear regression both suggest that DNA damage reported by farmers may influence individual, occupational, and residential factors and are reported as significant predictor factors, whereas this effect is mainly caused by individual factors among the control group. The findings of the present study suggest that either farmer or control group bear certain extent of genotoxic burden contributed by different risk factors. |
| first_indexed | 2024-03-06T08:57:23Z |
| format | Article |
| id | upm.eprints-44043 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:57:23Z |
| publishDate | 2015 |
| publisher | Taylor & Francis Inc |
| record_format | dspace |
| spelling | upm.eprints-440432022-03-10T09:13:39Z http://psasir.upm.edu.my/id/eprint/44043/ Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates How, Vivien Hashim, Zailina Ismail, Patimah Omar, Dzolkhifli Md Said, Salmiah Mohd Tamrin, Shamsul Bahri This is a cross-sectional study conducted among paddy farmers to characterize potential risk factors that influence levels of DNA damage from exposure to mixtures of organophosphates. Comet assay was used to determine the level of DNA damage by measuring the comet tail length from the exfoliated buccal mucosa. The result suggests that farmers who chronically exposure to a mixture of organophosphates has at least 2-fold significant increase of DNA damage as compared with control group. Factor analysis and linear regression both suggest that DNA damage reported by farmers may influence individual, occupational, and residential factors and are reported as significant predictor factors, whereas this effect is mainly caused by individual factors among the control group. The findings of the present study suggest that either farmer or control group bear certain extent of genotoxic burden contributed by different risk factors. Taylor & Francis Inc 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/44043/1/Characterization%20of%20risk%20factors%20for%20DNA%20damage%20among%20paddy%20farm%20worker%20exposed%20to%20mixtures%20of%20organophosphates.pdf How, Vivien and Hashim, Zailina and Ismail, Patimah and Omar, Dzolkhifli and Md Said, Salmiah and Mohd Tamrin, Shamsul Bahri (2015) Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates. Archives of Environmental & Occupational Health, 70 (2). pp. 102-109. ISSN 1933-8244; ESSN: 2154-4700 https://www.tandfonline.com/doi/abs/10.1080/19338244.2013.823905?journalCode=vaeh20 10.1080/19338244.2013.823905 |
| spellingShingle | How, Vivien Hashim, Zailina Ismail, Patimah Omar, Dzolkhifli Md Said, Salmiah Mohd Tamrin, Shamsul Bahri Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates |
| title | Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates |
| title_full | Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates |
| title_fullStr | Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates |
| title_full_unstemmed | Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates |
| title_short | Characterization of risk factors for DNA damage among paddy farm worker exposed to mixtures of organophosphates |
| title_sort | characterization of risk factors for dna damage among paddy farm worker exposed to mixtures of organophosphates |
| url | http://psasir.upm.edu.my/id/eprint/44043/1/Characterization%20of%20risk%20factors%20for%20DNA%20damage%20among%20paddy%20farm%20worker%20exposed%20to%20mixtures%20of%20organophosphates.pdf |
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