Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model
This current study investigated the anti-ulcer activity of 2 types of virgin coconut oil (VCO-A and VCO-B) and coconut oil (CO). Sprague-Dawley of male rats divided into 6 groups and each group consisted of ten rats. Rats were then treated with either VCO or CO and then were then anaesthetized and p...
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| Format: | Article |
| Language: | English |
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Cellmed Orthocellular Medicine and Pharmaceutical Association
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/44116/1/Comparative%20investigation%20into%20the%20anti-ulcer%20activity%20of%20virgin%20coconut%20oil%20and%20coconut%20oil%20in%20pylorous%20ligated%20animal%20model.pdf |
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| author | Selvaraja, Malarvili Ahmad, Zuraini Zakaria, Zainul Amiruddin Chiong, Hoe Siong Yong, Yoke Kin Long, Kamariah Hakim, Muhammad Nazrul |
| author_facet | Selvaraja, Malarvili Ahmad, Zuraini Zakaria, Zainul Amiruddin Chiong, Hoe Siong Yong, Yoke Kin Long, Kamariah Hakim, Muhammad Nazrul |
| author_sort | Selvaraja, Malarvili |
| collection | UPM |
| description | This current study investigated the anti-ulcer activity of 2 types of virgin coconut oil (VCO-A and VCO-B) and coconut oil (CO). Sprague-Dawley of male rats divided into 6 groups and each group consisted of ten rats. Rats were then treated with either VCO or CO and then were then anaesthetized and pyloric ligation was performed. The anaesthesia was discontinued and the animal usually recovered consciousness within less than an hour. Three hours later, the animal was then again anaesthetized and sacrificed with chloroform. Stomach removed and its content subjected to measurement of volume and pH. The results revealed VCO-B and VCO-A (100%) significantly inhibited (p < 0.001) the volume of gastric juice secreted by the control rats by 66.81% and 51.53%, respectively. Followed by CO 42.80%. While the inhibition of gastric juice for positive control rats which treated with ranitidine (100 mg/kg) was only 22.38%. The total acid output was reduced by the oils to 70.80%, 74.16% and 40.45% for VCO-A, VCO-B and CO respectively compared to control group. Ranitidine reduced the total acid output by 34.83%. In conclusion, prevention of gastric lesions in rats by VCO was found to increase the mucous and decrease the acid volume, total acid contents and ulcer scoring. The treatment of VCO affects the all parameters that influence the initiation and perpetuation of ulceration. |
| first_indexed | 2024-03-06T08:57:32Z |
| format | Article |
| id | upm.eprints-44116 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:57:32Z |
| publishDate | 2015 |
| publisher | Cellmed Orthocellular Medicine and Pharmaceutical Association |
| record_format | dspace |
| spelling | upm.eprints-441162022-02-12T02:51:21Z http://psasir.upm.edu.my/id/eprint/44116/ Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model Selvaraja, Malarvili Ahmad, Zuraini Zakaria, Zainul Amiruddin Chiong, Hoe Siong Yong, Yoke Kin Long, Kamariah Hakim, Muhammad Nazrul This current study investigated the anti-ulcer activity of 2 types of virgin coconut oil (VCO-A and VCO-B) and coconut oil (CO). Sprague-Dawley of male rats divided into 6 groups and each group consisted of ten rats. Rats were then treated with either VCO or CO and then were then anaesthetized and pyloric ligation was performed. The anaesthesia was discontinued and the animal usually recovered consciousness within less than an hour. Three hours later, the animal was then again anaesthetized and sacrificed with chloroform. Stomach removed and its content subjected to measurement of volume and pH. The results revealed VCO-B and VCO-A (100%) significantly inhibited (p < 0.001) the volume of gastric juice secreted by the control rats by 66.81% and 51.53%, respectively. Followed by CO 42.80%. While the inhibition of gastric juice for positive control rats which treated with ranitidine (100 mg/kg) was only 22.38%. The total acid output was reduced by the oils to 70.80%, 74.16% and 40.45% for VCO-A, VCO-B and CO respectively compared to control group. Ranitidine reduced the total acid output by 34.83%. In conclusion, prevention of gastric lesions in rats by VCO was found to increase the mucous and decrease the acid volume, total acid contents and ulcer scoring. The treatment of VCO affects the all parameters that influence the initiation and perpetuation of ulceration. Cellmed Orthocellular Medicine and Pharmaceutical Association 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/44116/1/Comparative%20investigation%20into%20the%20anti-ulcer%20activity%20of%20virgin%20coconut%20oil%20and%20coconut%20oil%20in%20pylorous%20ligated%20animal%20model.pdf Selvaraja, Malarvili and Ahmad, Zuraini and Zakaria, Zainul Amiruddin and Chiong, Hoe Siong and Yong, Yoke Kin and Long, Kamariah and Hakim, Muhammad Nazrul (2015) Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model. Tang (Humanitas Medicine), 5 (4). p. 28. ISSN 2233-8985 http://koreascience.or.kr/article/JAKO201509651117176.page 10.5667/tang.2015.0030 |
| spellingShingle | Selvaraja, Malarvili Ahmad, Zuraini Zakaria, Zainul Amiruddin Chiong, Hoe Siong Yong, Yoke Kin Long, Kamariah Hakim, Muhammad Nazrul Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model |
| title | Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model |
| title_full | Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model |
| title_fullStr | Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model |
| title_full_unstemmed | Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model |
| title_short | Comparative investigation into the anti-ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model |
| title_sort | comparative investigation into the anti ulcer activity of virgin coconut oil and coconut oil in pylorous ligated animal model |
| url | http://psasir.upm.edu.my/id/eprint/44116/1/Comparative%20investigation%20into%20the%20anti-ulcer%20activity%20of%20virgin%20coconut%20oil%20and%20coconut%20oil%20in%20pylorous%20ligated%20animal%20model.pdf |
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