In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract
The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague–Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), com...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/45114/1/GARCINIA.pdf |
| _version_ | 1796974532679958528 |
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| author | Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul |
| author_facet | Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul |
| author_sort | Dyary, Hiewa O. |
| collection | UPM |
| description | The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague–Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T. evansi in HMI-9 medium with the addition of 25 µg/ml G. hombroniana aqueous extract. It was observed that the addition of G. hombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G. hombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds. |
| first_indexed | 2024-03-06T08:58:25Z |
| format | Article |
| id | upm.eprints-45114 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T08:58:25Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | upm.eprints-451142021-04-16T02:56:38Z http://psasir.upm.edu.my/id/eprint/45114/ In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague–Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T. evansi in HMI-9 medium with the addition of 25 µg/ml G. hombroniana aqueous extract. It was observed that the addition of G. hombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G. hombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds. Elsevier 2015-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45114/1/GARCINIA.pdf Dyary, Hiewa O. and Abd. Kadir, Arifah and Sharma, Reuben Sunil Kumar and Abdullah, Rasedee and Md. Sukari, Mohd Aspollah and Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Somchit, Muhammad Nazrul (2015) In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract. Research in Veterinary Science, 100. pp. 226-231. ISSN 0034-5288; ESSN: 1532-2661 https://www.sciencedirect.com/science/article/pii/S0034528815000612?via%3Dihub 10.1016/j.rvsc.2015.03.007 |
| spellingShingle | Dyary, Hiewa O. Abd. Kadir, Arifah Sharma, Reuben Sunil Kumar Abdullah, Rasedee Md. Sukari, Mohd Aspollah Zakaria, Zainul Amiruddin Ahmad, Zuraini Somchit, Muhammad Nazrul In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract |
| title | In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract |
| title_full | In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract |
| title_fullStr | In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract |
| title_full_unstemmed | In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract |
| title_short | In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract |
| title_sort | in vivo antitrypanosomal activity of garcinia hombroniana aqueous extract |
| url | http://psasir.upm.edu.my/id/eprint/45114/1/GARCINIA.pdf |
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