Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibit...

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Main Authors: Nahta, Rita, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Andrade Vieira, Rafaela, Bay, Sarah N., Brown, Dustin G., Calaf, Gloria M., Castellino, Robert C., Cohen Solal, Karine A., Colacci, Anna Maria, Cruickshanks, Nichola, Dent, Paul, Di Fiore, Riccardo, Forte, Stefano, Goldberg, Gary S., A. Hamid, Roslida, Krishnan, Harini, Laird, Dale W., Lasfar, Ahmed, Marignani, Paola A., Memeo, Lorenzo, Mondello, Chiara, Naus, Christian C., Ponce Cusi, Richard, Raju, Jayadev, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Vento, Renza, Vondrá ček, Jan, Wade, Mark, Woodrick, Jordan, Bisson, William H.
Format: Article
Language:English
Published: Oxford University Press 2015
Online Access:http://psasir.upm.edu.my/id/eprint/45440/1/DNA.pdf
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author Nahta, Rita
Al-Mulla, Fahd
Al-Temaimi, Rabeah
Amedei, Amedeo
Andrade Vieira, Rafaela
Bay, Sarah N.
Brown, Dustin G.
Calaf, Gloria M.
Castellino, Robert C.
Cohen Solal, Karine A.
Colacci, Anna Maria
Cruickshanks, Nichola
Dent, Paul
Di Fiore, Riccardo
Forte, Stefano
Goldberg, Gary S.
A. Hamid, Roslida
Krishnan, Harini
Laird, Dale W.
Lasfar, Ahmed
Marignani, Paola A.
Memeo, Lorenzo
Mondello, Chiara
Naus, Christian C.
Ponce Cusi, Richard
Raju, Jayadev
Roy, Debasish
Roy, Rabindra
Ryan, Elizabeth P.
Salem, Hosni K.
Scovassi, A. Ivana
Singh, Neetu
Vaccari, Monica
Vento, Renza
Vondrá ček, Jan
Wade, Mark
Woodrick, Jordan
Bisson, William H.
author_facet Nahta, Rita
Al-Mulla, Fahd
Al-Temaimi, Rabeah
Amedei, Amedeo
Andrade Vieira, Rafaela
Bay, Sarah N.
Brown, Dustin G.
Calaf, Gloria M.
Castellino, Robert C.
Cohen Solal, Karine A.
Colacci, Anna Maria
Cruickshanks, Nichola
Dent, Paul
Di Fiore, Riccardo
Forte, Stefano
Goldberg, Gary S.
A. Hamid, Roslida
Krishnan, Harini
Laird, Dale W.
Lasfar, Ahmed
Marignani, Paola A.
Memeo, Lorenzo
Mondello, Chiara
Naus, Christian C.
Ponce Cusi, Richard
Raju, Jayadev
Roy, Debasish
Roy, Rabindra
Ryan, Elizabeth P.
Salem, Hosni K.
Scovassi, A. Ivana
Singh, Neetu
Vaccari, Monica
Vento, Renza
Vondrá ček, Jan
Wade, Mark
Woodrick, Jordan
Bisson, William H.
author_sort Nahta, Rita
collection UPM
description As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
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spelling upm.eprints-454402021-05-06T23:28:16Z http://psasir.upm.edu.my/id/eprint/45440/ Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression Nahta, Rita Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Andrade Vieira, Rafaela Bay, Sarah N. Brown, Dustin G. Calaf, Gloria M. Castellino, Robert C. Cohen Solal, Karine A. Colacci, Anna Maria Cruickshanks, Nichola Dent, Paul Di Fiore, Riccardo Forte, Stefano Goldberg, Gary S. A. Hamid, Roslida Krishnan, Harini Laird, Dale W. Lasfar, Ahmed Marignani, Paola A. Memeo, Lorenzo Mondello, Chiara Naus, Christian C. Ponce Cusi, Richard Raju, Jayadev Roy, Debasish Roy, Rabindra Ryan, Elizabeth P. Salem, Hosni K. Scovassi, A. Ivana Singh, Neetu Vaccari, Monica Vento, Renza Vondrá ček, Jan Wade, Mark Woodrick, Jordan Bisson, William H. As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks. Oxford University Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/45440/1/DNA.pdf Nahta, Rita and Al-Mulla, Fahd and Al-Temaimi, Rabeah and Amedei, Amedeo and Andrade Vieira, Rafaela and Bay, Sarah N. and Brown, Dustin G. and Calaf, Gloria M. and Castellino, Robert C. and Cohen Solal, Karine A. and Colacci, Anna Maria and Cruickshanks, Nichola and Dent, Paul and Di Fiore, Riccardo and Forte, Stefano and Goldberg, Gary S. and A. Hamid, Roslida and Krishnan, Harini and Laird, Dale W. and Lasfar, Ahmed and Marignani, Paola A. and Memeo, Lorenzo and Mondello, Chiara and Naus, Christian C. and Ponce Cusi, Richard and Raju, Jayadev and Roy, Debasish and Roy, Rabindra and Ryan, Elizabeth P. and Salem, Hosni K. and Scovassi, A. Ivana and Singh, Neetu and Vaccari, Monica and Vento, Renza and Vondrá ček, Jan and Wade, Mark and Woodrick, Jordan and Bisson, William H. (2015) Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis, 36 (suppl. 1). pp. 2-18. ISSN 0143-3334; ESSN: 1460-2180 https://pubmed.ncbi.nlm.nih.gov/26106139/ 10.1093/carcin/bgv028
spellingShingle Nahta, Rita
Al-Mulla, Fahd
Al-Temaimi, Rabeah
Amedei, Amedeo
Andrade Vieira, Rafaela
Bay, Sarah N.
Brown, Dustin G.
Calaf, Gloria M.
Castellino, Robert C.
Cohen Solal, Karine A.
Colacci, Anna Maria
Cruickshanks, Nichola
Dent, Paul
Di Fiore, Riccardo
Forte, Stefano
Goldberg, Gary S.
A. Hamid, Roslida
Krishnan, Harini
Laird, Dale W.
Lasfar, Ahmed
Marignani, Paola A.
Memeo, Lorenzo
Mondello, Chiara
Naus, Christian C.
Ponce Cusi, Richard
Raju, Jayadev
Roy, Debasish
Roy, Rabindra
Ryan, Elizabeth P.
Salem, Hosni K.
Scovassi, A. Ivana
Singh, Neetu
Vaccari, Monica
Vento, Renza
Vondrá ček, Jan
Wade, Mark
Woodrick, Jordan
Bisson, William H.
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
title Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
title_full Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
title_fullStr Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
title_full_unstemmed Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
title_short Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
title_sort mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression
url http://psasir.upm.edu.my/id/eprint/45440/1/DNA.pdf
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